{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:39:32Z","timestamp":1792420772684,"version":"4.5.0"},"reference-count":79,"publisher":"Rockefeller University Press","issue":"12","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS121179"],"award-info":[{"award-number":["R01NS121179"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31NS129199"],"award-info":[{"award-number":["F31NS129199"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2227609"],"award-info":[{"award-number":["2227609"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,12,7]]},"abstract":"<jats:p>Mitochondrial transport, fusion, and fission are necessary for neuronal development, but the role of mitochondrial dynamics in neuronal maintenance remains unclear. In this work, we employed functional in vivo imaging of neurons in the Drosophila visual system, \u201chorizontal system\u201d (HS) cells, to determine how adult-onset deficits in mitochondrial dynamics affect mitochondrial localization, local regulation of ATP, and dendrite maintenance. In mature HS neurons, inhibition of mitochondrial transport or fusion depleted mitochondria from the dendrite over time but, surprisingly, had no effect on dendrite morphology. Moreover, adult-restricted mitochondrial mislocalization affected neither visual stimulus-driven dendritic calcium responses nor local, dynamic regulation of ATP levels. In contrast, when induced during development, the same perturbations caused mitochondrial mislocalization, loss of dendrite complexity, abrogation of stimulus-locked calcium responses and ATP fluctuations, and age-dependent dendrite degeneration. Thus, although mitochondrial dynamics are necessary during neuronal development, mature dendrites are capable of maintaining form and function in vivo upon mitochondrial depletion.<\/jats:p>","DOI":"10.1083\/jcb.202511010","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:42:42Z","timestamp":1792417362000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Drosophila<\/i>\n                    dendrites are resilient to adult-onset deficits in mitochondrial dynamics"],"prefix":"10.1083","volume":"225","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4929-0168","authenticated-orcid":true,"given":"Hailey Q.","family":"Wang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Columbia University, New York, NY, USA 1 Department of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2998-2887","authenticated-orcid":true,"given":"Demetria G.","family":"Fortson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Columbia University, New York, NY, USA 1 Department of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5904-8792","authenticated-orcid":true,"given":"Eavan D.","family":"Burton","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Columbia University, New York, NY, USA 1 Department of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9032-5161","authenticated-orcid":true,"given":"Hunter S.","family":"Whitbeck","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Columbia University, New York, NY, USA 1 Department of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7071-1598","authenticated-orcid":true,"given":"Briana M.","family":"Robles","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Columbia University, New York, NY, USA 1 Department of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3483-5974","authenticated-orcid":true,"given":"Kwass","family":"Wass","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Columbia University, New York, NY, USA 1 Department of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0181-3268","authenticated-orcid":true,"given":"Letitia","family":"Bortey","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Columbia University, New York, NY, USA 1 Department of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-8683","authenticated-orcid":true,"given":"Avi J.","family":"Adler","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Columbia University, New York, NY, USA 1 Department of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-2919","authenticated-orcid":true,"given":"Jordan I.","family":"Kalai","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Columbia University, New York, NY, USA 1 Department of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0560-8346","authenticated-orcid":true,"given":"Giovanna","family":"Napoleone","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Columbia University, New York, NY, USA 1 Department of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0846-2157","authenticated-orcid":true,"given":"Erin L.","family":"Barnhart","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hj8s172","id-type":"ROR","asserted-by":"publisher"}],"name":"Columbia University, New York, NY, USA 1 Department of Biological Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"2026101909422255300_bib1","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1126\/science.1174331","article-title":"Energy-efficient action potentials in hippocampal mossy fibers","volume":"325","author":"Alle","year":"2009","journal-title":"Science"},{"key":"2026101909422255300_bib2","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1083\/jcb.201401070","article-title":"Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin","volume":"206","author":"Ashrafi","year":"2014","journal-title":"J. Cell Biol."},{"key":"2026101909422255300_bib3","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.neuron.2016.12.020","article-title":"GLUT4 mobilization supports energetic demands of active synapses","volume":"93","author":"Ashrafi","year":"2017","journal-title":"Neuron"},{"key":"2026101909422255300_bib4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.neuron.2018.08.022","article-title":"Sequential nonlinear filtering of local motion cues by global motion circuits","volume":"100","author":"Barnhart","year":"2018","journal-title":"Neuron"},{"key":"2026101909422255300_bib5","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1038\/s41592-019-0582-9","article-title":"Ilastik: Interactive machine learning for (bio)image analysis","volume":"16","author":"Berg","year":"2019","journal-title":"Nat. Methods"},{"key":"2026101909422255300_bib6","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1038\/s41467-025-56640-0","article-title":"How energy determines spatial localisation and copy number of molecules in neurons","volume":"16","author":"Bergmann","year":"2025","journal-title":"Nat. Commun."},{"key":"2026101909422255300_bib7","doi-asserted-by":"publisher","first-page":"14304","DOI":"10.1523\/JNEUROSCI.0930-14.2014","article-title":"Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons","volume":"34","author":"Berthet","year":"2014","journal-title":"J. Neurosci."},{"key":"2026101909422255300_bib8","doi-asserted-by":"publisher","first-page":"4037","DOI":"10.1016\/j.cub.2018.11.010","article-title":"Bi-directional control of walking behavior by horizontal optic flow sensors","volume":"28","author":"Busch","year":"2018","journal-title":"Curr. Biol."},{"key":"2026101909422255300_bib9","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.neuron.2009.12.011","article-title":"Sodium entry during action potentials of mammalian neurons: Incomplete inactivation and reduced metabolic efficiency in fast-spiking neurons","volume":"64","author":"Carter","year":"2009","journal-title":"Neuron"},{"key":"2026101909422255300_bib10","doi-asserted-by":"publisher","first-page":"ar123","DOI":"10.1091\/mbc.E22-03-0111","article-title":"Spatiotemporal analysis of axonal autophagosome-lysosome dynamics reveals limited fusion events and slow maturation","volume":"33","author":"Cason","year":"2022","journal-title":"Mol. Biol. Cell"},{"key":"2026101909422255300_bib11","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"2026101909422255300_bib12","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.cell.2007.06.026","article-title":"Mitochondrial fusion protects against neurodegeneration in the cerebellum","volume":"130","author":"Chen","year":"2007","journal-title":"Cell"},{"key":"2026101909422255300_bib13","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1016\/j.cell.2013.05.021","article-title":"Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture","volume":"153","author":"Courchet","year":"2013","journal-title":"Cell"},{"key":"2026101909422255300_bib14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s12021-010-9093-7","article-title":"The TREES toolbox-probing the basis of axonal and dendritic branching","volume":"9","author":"Cuntz","year":"2011","journal-title":"Neuroinformatics"},{"key":"2026101909422255300_bib15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000251","article-title":"The morphological identity of insect dendrites","volume":"4","author":"Cuntz","year":"2008","journal-title":"PLoS Comput. Biol."},{"key":"2026101909422255300_bib16","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12727","article-title":"Sensitive red protein calcium indicators for imaging neural activity","volume":"5","author":"Dana","year":"2016","journal-title":"Elife"},{"key":"2026101909422255300_bib17","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/79936","article-title":"Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy","volume":"26","author":"Delettre","year":"2000","journal-title":"Nat. Genet."},{"key":"2026101909422255300_bib18","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/nrn.2017.170","article-title":"Mitochondria at the neuronal presynapse in health and disease","volume":"19","author":"Devine","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"2026101909422255300_bib19","doi-asserted-by":"publisher","first-page":"15716","DOI":"10.1523\/JNEUROSCI.3159-11.2011","article-title":"PKA\/AKAP1 and PP2A\/Bbeta2 regulate neuronal morphogenesis via Drp1 phosphorylation and mitochondrial bioenergetics","volume":"31","author":"Dickey","year":"2011","journal-title":"J. Neurosci."},{"key":"2026101909422255300_bib20","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.neuron.2018.09.025","article-title":"Long-term potentiation requires a rapid burst of dendritic mitochondrial fission during induction","volume":"100","author":"Divakaruni","year":"2018","journal-title":"Neuron"},{"key":"2026101909422255300_bib21","doi-asserted-by":"publisher","first-page":"114190","DOI":"10.1016\/j.celrep.2024.114190","article-title":"Dendrite architecture determines mitochondrial distribution patterns in vivo","volume":"43","author":"Donovan","year":"2024","journal-title":"Cell Rep."},{"key":"2026101909422255300_bib22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010055","article-title":"Mitochondrial fusion regulates proliferation and differentiation in the type II neuroblast lineage in Drosophila","volume":"18","author":"Dubal","year":"2022","journal-title":"PLoS Genet."},{"key":"2026101909422255300_bib23","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1038\/s41593-025-01948-9","article-title":"A competitive disinhibitory network for robust optic flow processing in Drosophila","volume":"28","author":"Erginkaya","year":"2025","journal-title":"Nat. Neurosci."},{"key":"2026101909422255300_bib24","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11583","article-title":"Dendritic mitochondria reach stable positions during circuit development","volume":"5","author":"Faits","year":"2016","journal-title":"Elife"},{"key":"2026101909422255300_bib25","doi-asserted-by":"publisher","first-page":"ENEURO.0049-14.2014","DOI":"10.1523\/ENEURO.0049-14.2014","article-title":"neuTube 1.0: A new design for efficient neuron reconstruction software based on the SWC format","volume":"2","author":"Feng","year":"2015","journal-title":"eNeuro"},{"key":"2026101909422255300_bib26","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1038\/s41556-024-01544-2","article-title":"FMRP regulates MFF translation to locally direct mitochondrial fission in neurons","volume":"26","author":"Fenton","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"2026101909422255300_bib27","doi-asserted-by":"publisher","first-page":"5707","DOI":"10.1523\/JNEUROSCI.4115-14.2015","article-title":"Synergistic action of dendritic mitochondria and creatine kinase maintains ATP homeostasis and actin dynamics in growing neuronal dendrites","volume":"35","author":"Fukumitsu","year":"2015","journal-title":"J. Neurosci."},{"key":"2026101909422255300_bib28","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1083\/jcb.200601067","article-title":"Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent","volume":"173","author":"Glater","year":"2006","journal-title":"J. Cell Biol."},{"key":"2026101909422255300_bib29","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.neuron.2021.12.029","article-title":"Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons","volume":"110","author":"Goldsmith","year":"2022","journal-title":"Neuron"},{"key":"2026101909422255300_bib30","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1126\/science.162.3859.12","article-title":"The tragedy of the commons","volume":"162","author":"Hardin","year":"1968","journal-title":"Science"},{"key":"2026101909422255300_bib31","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41592-020-01008-z","article-title":"nnU-Net: A self-configuring method for deep learning-based biomedical image segmentation","volume":"18","author":"Isensee","year":"2021","journal-title":"Nat. Methods"},{"key":"2026101909422255300_bib32","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/ncb1907","article-title":"Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice","volume":"11","author":"Ishihara","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"2026101909422255300_bib33","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1126\/science.aba9760","article-title":"Mitochondrial dynamics in postmitotic cells regulate neurogenesis","volume":"369","author":"Iwata","year":"2020","journal-title":"Science"},{"key":"2026101909422255300_bib34","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.neuron.2016.03.011","article-title":"Glycolytic enzymes localize to synapses under energy stress to support synaptic function","volume":"90","author":"Jang","year":"2016","journal-title":"Neuron"},{"key":"2026101909422255300_bib35","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.cell.2016.12.005","article-title":"Quantitative predictions orchestrate visual signaling in Drosophila","volume":"168","author":"Kim","year":"2017","journal-title":"Cell"},{"key":"2026101909422255300_bib36","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1016\/j.neuron.2024.03.013","article-title":"Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons","volume":"112","author":"Kochan","year":"2024","journal-title":"Neuron"},{"key":"2026101909422255300_bib37","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1152\/jn.1998.79.4.1902","article-title":"Dendritic structure and receptive-field organization of optic flow processing interneurons in the fly","volume":"79","author":"Krapp","year":"1998","journal-title":"J. Neurophysiol."},{"key":"2026101909422255300_bib38","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1038\/s42255-025-01321-x","article-title":"Triglycerides are an important fuel reserve for synapse function in the brain","volume":"7","author":"Kumar","year":"2025","journal-title":"Nat. Metab."},{"key":"2026101909422255300_bib39","doi-asserted-by":"publisher","first-page":"5008","DOI":"10.1038\/s41467-018-07416-2","article-title":"MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size","volume":"9","author":"Lewis","year":"2018","journal-title":"Nat. Commun."},{"key":"2026101909422255300_bib40","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1016\/j.cub.2016.07.064","article-title":"Progressive decrease of mitochondrial motility during maturation of cortical axons in vitro and in vivo","volume":"26","author":"Lewis","year":"2016","journal-title":"Curr. Biol."},{"key":"2026101909422255300_bib41","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.cell.2004.11.003","article-title":"The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses","volume":"119","author":"Li","year":"2004","journal-title":"Cell"},{"key":"2026101909422255300_bib42","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.neuron.2017.04.004","article-title":"Releasing Syntaphilin removes stressed mitochondria from axons independent of mitophagy under pathophysiological conditions","volume":"94","author":"Lin","year":"2017","journal-title":"Neuron"},{"key":"2026101909422255300_bib43","doi-asserted-by":"publisher","first-page":"8599","DOI":"10.1073\/pnas.1002471107","article-title":"Flow of energy in the outer retina in darkness and in light","volume":"107","author":"Linton","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026101909422255300_bib44","doi-asserted-by":"publisher","first-page":"3408","DOI":"10.1016\/j.cell.2022.07.013","article-title":"Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy","volume":"185","author":"Liu","year":"2022","journal-title":"Cell"},{"key":"2026101909422255300_bib45","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.celrep.2016.09.004","article-title":"Loss of dendritic complexity precedes neurodegeneration in a mouse model with disrupted mitochondrial distribution in mature dendrites","volume":"17","author":"L\u00f3pez-Dom\u00e9nech","year":"2016","journal-title":"Cell Rep."},{"key":"2026101909422255300_bib46","doi-asserted-by":"publisher","DOI":"10.3791\/52741","article-title":"Quantitative analysis of climbing defects in a Drosophila model of neurodegenerative disorders","volume":"2025","author":"Madabattula","year":"2015","journal-title":"J. Vis. Exp."},{"key":"2026101909422255300_bib47","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1083\/jcb.201106120","article-title":"Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons","volume":"196","author":"Maday","year":"2012","journal-title":"J. Cell Biol"},{"key":"2026101909422255300_bib48","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/nature12320","article-title":"A directional tuning map of Drosophila elementary motion detectors","volume":"500","author":"Maisak","year":"2013","journal-title":"Nature"},{"key":"2026101909422255300_bib49","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1523\/JNEUROSCI.1316-20.2020","article-title":"Retrograde mitochondrial transport is essential for organelle distribution and health in zebrafish neurons","volume":"41","author":"Mandal","year":"2021","journal-title":"J. Neurosci."},{"key":"2026101909422255300_bib50","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s41586-021-03497-0","article-title":"Coupling of activity, metabolism and behaviour across the Drosophila brain","volume":"593","author":"Mann","year":"2021","journal-title":"Nature"},{"key":"2026101909422255300_bib51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2314604121","article-title":"iATPSnFR2: A high-dynamic-range fluorescent sensor for monitoring intracellular ATP","volume":"121","author":"Marvin","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026101909422255300_bib52","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.cell.2015.06.035","article-title":"Neural circuit to integrate opposing motions in the visual field","volume":"162","author":"Mauss","year":"2015","journal-title":"Cell"},{"key":"2026101909422255300_bib53","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1242\/jcs.01130","article-title":"Axonal mitochondrial transport and potential are correlated","volume":"117","author":"Miller","year":"2004","journal-title":"J. Cell Sci."},{"key":"2026101909422255300_bib54","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.neuron.2017.09.055","article-title":"Mitostasis in neurons: Maintaining mitochondria in an extended cellular architecture","volume":"96","author":"Misgeld","year":"2017","journal-title":"Neuron"},{"key":"2026101909422255300_bib55","doi-asserted-by":"publisher","first-page":"4232","DOI":"10.1523\/JNEUROSCI.6248-09.2010","article-title":"Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro\/Milton complex","volume":"30","author":"Misko","year":"2010","journal-title":"J. Neurosci."},{"key":"2026101909422255300_bib56","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1242\/jcs.104.3.917","article-title":"The regulation of bidirectional mitochondrial transport is coordinated with axonal outgrowth","volume":"104","author":"Morris","year":"1993","journal-title":"J. Cell Sci."},{"key":"2026101909422255300_bib57","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/s41586-025-08746-0","article-title":"Connectome-driven neural inventory of a complete visual system","volume":"641","author":"Nern","year":"2025","journal-title":"Nature"},{"key":"2026101909422255300_bib58","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.conb.2016.09.004","article-title":"Neuronal energy consumption: Biophysics, efficiency and evolution","volume":"41","author":"Niven","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"2026101909422255300_bib59","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41592-022-01426-1","article-title":"SLEAP: A deep learning system for multi-animal pose tracking","volume":"19","author":"Pereira","year":"2022","journal-title":"Nat. Methods"},{"key":"2026101909422255300_bib60","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson\u2019s disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"2026101909422255300_bib61","doi-asserted-by":"publisher","first-page":"16203","DOI":"10.1523\/JNEUROSCI.1327-12.2012","article-title":"In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system","volume":"32","author":"Pluci\u0144ska","year":"2012","journal-title":"J. Neurosci."},{"key":"2026101909422255300_bib62","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/s41467-017-00525-4","article-title":"Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster","volume":"8","author":"Rana","year":"2017","journal-title":"Nat. Commun."},{"key":"2026101909422255300_bib63","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.cell.2013.12.042","article-title":"Activity-driven local ATP synthesis is required for synaptic function","volume":"156","author":"Rangaraju","year":"2014","journal-title":"Cell"},{"key":"2026101909422255300_bib64","doi-asserted-by":"publisher","first-page":"5443","DOI":"10.1016\/j.cub.2025.09.063","article-title":"Metabolic rewiring prevents neurodegeneration caused by chronic mitochondrial dysfunction","volume":"35","author":"Richhariya","year":"2025","journal-title":"Curr. Biol."},{"key":"2026101909422255300_bib65","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1113\/JP273105","article-title":"Na+ \/H+ exchange via the Drosophila vesicular glutamate transporter mediates activity-induced acid efflux from presynaptic terminals","volume":"595","author":"Rossano","year":"2017","journal-title":"J. Physiol."},{"key":"2026101909422255300_bib66","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1152\/jn.00950.2009","article-title":"Processing of horizontal optic flow in three visual interneurons of the Drosophila brain","volume":"103","author":"Schnell","year":"2010","journal-title":"J. Neurophysiol."},{"key":"2026101909422255300_bib67","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1002\/cne.10467","article-title":"Structure of the vertical and horizontal system neurons of the lobula plate in Drosophila","volume":"454","author":"Scott","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"2026101909422255300_bib68","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.tcb.2017.01.005","article-title":"The interplay of axonal energy homeostasis and mitochondrial trafficking and anchoring","volume":"27","author":"Sheng","year":"2017","journal-title":"Trends Cell Biol."},{"key":"2026101909422255300_bib69","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62091","article-title":"Activity-dependent regulation of mitochondrial motility in developing cortical dendrites","volume":"10","author":"Silva","year":"2021","journal-title":"Elife"},{"key":"2026101909422255300_bib70","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1016\/j.cub.2016.07.033","article-title":"Mitochondrial dynamics in visual cortex are limited in vivo and not affected by axonal structural plasticity","volume":"26","author":"Smit-Rigter","year":"2016","journal-title":"Curr. Biol."},{"key":"2026101909422255300_bib71","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/s0896-6273(02)01094-2","article-title":"Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein","volume":"36","author":"Stowers","year":"2002","journal-title":"Neuron"},{"key":"2026101909422255300_bib72","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1038\/s41467-025-57399-0","article-title":"Mitochondria are positioned at dendritic branch induction sites, a process requiring rhotekin2 and syndapin I","volume":"16","author":"Tr\u00f6ger","year":"2025","journal-title":"Nat. Commun."},{"key":"2026101909422255300_bib73","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.cub.2018.02.048","article-title":"A cAMP\/PKA\/Kinesin-1 axis promotes the axonal transport of mitochondria in aging Drosophila neurons","volume":"28","author":"Vagnoni","year":"2018","journal-title":"Curr. Biol."},{"key":"2026101909422255300_bib74","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.neuron.2005.06.018","article-title":"Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions","volume":"47","author":"Verstreken","year":"2005","journal-title":"Neuron"},{"key":"2026101909422255300_bib75","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.1523\/JNEUROSCI.1356-22.2023","article-title":"Mitofusin 2 sustains the axonal mitochondrial network to support presynaptic Ca2+ homeostasis and the synaptic vesicle cycle in rat hippocampal axons","volume":"43","author":"Vevea","year":"2023","journal-title":"J. Neurosci."},{"key":"2026101909422255300_bib76","doi-asserted-by":"publisher","first-page":"6400","DOI":"10.1073\/pnas.1221132110","article-title":"The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo","volume":"110","author":"Vincow","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026101909422255300_bib77","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1042\/bj2810021","article-title":"Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The \u2018phosphocreatine circuit\u2019 for cellular energy homeostasis","volume":"281","author":"Wallimann","year":"1992","journal-title":"Biochem. J."},{"key":"2026101909422255300_bib78","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2314699121","article-title":"Local and dynamic regulation of neuronal glycolysis in vivo","volume":"121","author":"Wolfe","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026101909422255300_bib79","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/ng1341","article-title":"Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A","volume":"36","author":"Z\u00fcchner","year":"2004","journal-title":"Nat. Genet."}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.202511010\/2042229\/jcb_202511010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.202511010\/2042229\/jcb_202511010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:42:43Z","timestamp":1792417363000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/225\/12\/e202511010\/283085\/Drosophila-dendrites-are-resilient-to-adult-onset"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":79,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12,7]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.202511010","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]},"article-number":"e202511010"}}