{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:59:56Z","timestamp":1792785596952,"version":"4.5.0"},"reference-count":55,"publisher":"Rockefeller University Press","issue":"1","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/rupress.org\/pages\/terms102024"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/BIA-BFS\/0812\/2021"],"award-info":[{"award-number":["PTDC\/BIA-BFS\/0812\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["2022.06763.CEECIND"],"award-info":[{"award-number":["2022.06763.CEECIND"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["2020.02149.CEECIND"],"award-info":[{"award-number":["2020.02149.CEECIND"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["2022.11122.BD"],"award-info":[{"award-number":["2022.11122.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Portuguese Platform of BioImaging","award":["POCI-01-0145-FEDER-022122"],"award-info":[{"award-number":["POCI-01-0145-FEDER-022122"]}],"id":[{"id":"https:\/\/ror.org\/0479zfq62","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2027,1,4]]},"abstract":"<jats:p>Weakening of adherens junctions (AJs) and focal adhesions (FAs) adhesiveness has been proposed to enable cancer initiation and progression. Here we report that E-cadherin at cell\u2013cell contacts and vinculin at FAs are transiently under higher tension in MCF10A cells overactivating the Src proto-oncogene. Knockdown of paxillin or P-cadherin, or inhibition of focal adhesion kinase (FAK) or AJ assembly with EGTA, suppresses this force increase across both E-cadherin and vinculin. FAK and P-cadherin trans-homophilic interactions further enhance Src-dependent myosin II and extracellular signal-regulated kinase (ERK) activation. In addition, FAK and P-cadherin potentiate ERK and serum response factor (SRF) signaling, thereby supporting cell proliferation. Furthermore, knockdown of Drosophila cadherin or alpha integrin suppresses Src-induced tissue overgrowth, reinforcing the role of adhesion integrity in Src-driven proliferation. Thus, prior to the loss of cell\u2013cell and cell\u2013matrix adhesiveness, adhesion integrity by P-cadherin at AJs and FAK at FAs could represent a critical step enabling premalignant cells to gain a proliferative advantage.<\/jats:p>","DOI":"10.1083\/jcb.202511205","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T14:08:57Z","timestamp":1792764537000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Adhesion integrity activates mechanosensitive proliferative signaling"],"prefix":"10.1083","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3283-2111","authenticated-orcid":true,"given":"L\u00eddia","family":"Faria","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto 1 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP) 2 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Doctoral Programme in Molecular and Cell Biology, School of Medicine & Biomedical Sciences, University of Porto (ICBAS-UP) 3 , Porto,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4512-6147","authenticated-orcid":true,"given":"Carine M.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto 1 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP) 2 , Porto,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0033-2285","authenticated-orcid":true,"given":"In\u00eas","family":"Fidalgo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto 1 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP) 2 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Master Programme in Oncology, School of Medicine & Biomedical Sciences, University of Porto (ICBAS-UP) 4 , Porto,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4574-7038","authenticated-orcid":true,"given":"Carlotta","family":"Mix","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto 1 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP) 2 , Porto,","place":["Portugal"]},{"name":"Hochschule Bremen, City University of Applied Sciences 5 , Bremen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7316-8283","authenticated-orcid":true,"given":"Maria M.","family":"Azevedo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto 1 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto 6 , Porto,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-8925","authenticated-orcid":true,"given":"Carla S.","family":"Lopes","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto 1 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto 6 , Porto,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3824-9827","authenticated-orcid":true,"given":"Olena","family":"Kostylenko","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto 1 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto 6 , Porto,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5991-4724","authenticated-orcid":true,"given":"Vanessa","family":"Rodrigues","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto 1 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP) 2 , Porto,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2222-3844","authenticated-orcid":true,"given":"Ricardo","family":"Bragu\u00eas","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto 1 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP) 2 , Porto,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1148-2159","authenticated-orcid":true,"given":"Paula","family":"Sampaio","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto 1 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto 6 , Porto,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-914X","authenticated-orcid":true,"given":"Sandra","family":"Tavares","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto 1 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP) 2 , Porto,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7969-4620","authenticated-orcid":true,"given":"Vaibhav","family":"Mahajan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/042aqky30","id-type":"ROR","asserted-by":"publisher"}],"name":"Biotechnology Center, Dresden University of Technology 7 , Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7916-0394","authenticated-orcid":true,"given":"Anna V.","family":"Taubenberger","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/042aqky30","id-type":"ROR","asserted-by":"publisher"}],"name":"Biotechnology Center, Dresden University of Technology 7 , Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4326-0163","authenticated-orcid":true,"given":"Florence","family":"Janody","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto 1 , Porto,","place":["Portugal"]},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP) 2 , Porto,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"2026102310071864800_bib1","doi-asserted-by":"publisher","first-page":"183316","DOI":"10.1016\/j.bbamem.2020.183316","article-title":"Cell-cell junctions as sensors and transducers of mechanical forces","volume":"1862","author":"Angulo-Urarte","year":"2020","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"2026102310071864800_bib2","doi-asserted-by":"publisher","first-page":"446","DOI":"10.7326\/0003-4819-143-6-200509200-00009","article-title":"Premalignant and in situ breast disease: Biology and clinical implications","volume":"143","author":"Arpino","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"2026102310071864800_bib3","author":"Bates","year":"2012"},{"key":"2026102310071864800_bib4","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/ncb3135","article-title":"Control of cell-cell forces and collective cell dynamics by the intercellular adhesome","volume":"17","author":"Bazelli\u00e8res","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"2026102310071864800_bib5","doi-asserted-by":"publisher","first-page":"12568","DOI":"10.1073\/pnas.1204390109","article-title":"E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch","volume":"109","author":"Borghi","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026102310071864800_bib6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12195-021-00694-9","article-title":"Epithelial-to-mesenchymal transition signaling pathways responsible for breast cancer metastasis","volume":"15","author":"Buyuk","year":"2022","journal-title":"Cell Mol. Bioeng."},{"key":"2026102310071864800_bib7","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.cub.2013.01.009","article-title":"Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner","volume":"23","author":"Carisey","year":"2013","journal-title":"Curr. Biol."},{"key":"2026102310071864800_bib8","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1242\/jcs.044008","article-title":"FAK, PIP5KIgamma and gelsolin cooperatively mediate force-induced expression of alpha-smooth muscle actin","volume":"122","author":"Chan","year":"2009","journal-title":"J. Cell Sci."},{"key":"2026102310071864800_bib9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/bies.201600123","article-title":"Integrin and cadherin clusters: A robust way to organize adhesions for cell mechanics","volume":"39","author":"Changede","year":"2017","journal-title":"Bioessays"},{"key":"2026102310071864800_bib10","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1038\/onc.2009.523","article-title":"Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer","volume":"29","author":"Cheung","year":"2010","journal-title":"Oncogene"},{"key":"2026102310071864800_bib11","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.devcel.2024.10.002","article-title":"EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues in Drosophila melanogaster","volume":"60","author":"Clarke","year":"2025","journal-title":"Dev. Cell"},{"key":"2026102310071864800_bib12","doi-asserted-by":"publisher","first-page":"111475","DOI":"10.1016\/j.celrep.2022.111475","article-title":"A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1","volume":"41","author":"Donker","year":"2022","journal-title":"Cell Rep."},{"key":"2026102310071864800_bib13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.JBO.24.12.126501","article-title":"FRET efficiency measurement in a molecular tension probe with a low-cost frequency-domain fluorescence lifetime imaging microscope","volume":"24","author":"Dumas","year":"2019","journal-title":"J. Biomed. Opt."},{"key":"2026102310071864800_bib14","doi-asserted-by":"publisher","first-page":"dmm049652","DOI":"10.1242\/dmm.049652","article-title":"Activation of an actin signaling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformation","volume":"16","author":"Faria","year":"2023","journal-title":"Dis. Model Mech."},{"key":"2026102310071864800_bib15","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1083\/jcb.134.3.793","article-title":"Control of adhesion-dependent cell survival by focal adhesion kinase","volume":"134","author":"Frisch","year":"1996","journal-title":"J. Cell Biol."},{"key":"2026102310071864800_bib16","doi-asserted-by":"publisher","first-page":"11458","DOI":"10.1038\/srep11458","article-title":"Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices","volume":"5","author":"Gjorevski","year":"2015","journal-title":"Sci. Rep."},{"key":"2026102310071864800_bib17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nature09198","article-title":"Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics","volume":"466","author":"Grashoff","year":"2010","journal-title":"Nature"},{"key":"2026102310071864800_bib18","doi-asserted-by":"publisher","first-page":"7524","DOI":"10.1038\/ncomms8524","article-title":"A plastic relationship between vinculin-mediated tension and adhesion complex area defines adhesion size and lifetime","volume":"6","author":"Hern\u00e1ndez-Varas","year":"2015","journal-title":"Nat. Commun."},{"key":"2026102310071864800_bib19","doi-asserted-by":"publisher","first-page":"7507","DOI":"10.1158\/0008-5472.CAN-09-2994","article-title":"Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission","volume":"69","author":"Hirsch","year":"2009","journal-title":"Cancer Res."},{"key":"2026102310071864800_bib20","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1002\/j.1460-2075.1982.tb01237.x","article-title":"Different modes of internalization of proteins associated with adhaerens junctions and desmosomes: Experimental separation of lateral contacts induces endocytosis of desmosomal plaque material","volume":"1","author":"Kartenbeck","year":"1982","journal-title":"EMBO J."},{"key":"2026102310071864800_bib21","doi-asserted-by":"publisher","first-page":"30433","DOI":"10.18632\/oncotarget.5448","article-title":"Tension across adherens junctions: When less is more","volume":"6","author":"Kruse","year":"2015","journal-title":"Oncotarget"},{"key":"2026102310071864800_bib22","doi-asserted-by":"publisher","first-page":"39518","DOI":"10.1038\/srep39518","article-title":"Disruption of cell adhesion by an antibody targeting the cell-adhesive intermediate (X-dimer) of human P-cadherin","volume":"7","author":"Kudo","year":"2017","journal-title":"Sci. Rep."},{"key":"2026102310071864800_bib23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011801","article-title":"p120ctn and P-cadherin but not E-cadherin regulate cell motility and invasion of DU145 prostate cancer cells","volume":"5","author":"K\u00fcmper","year":"2010","journal-title":"PLoS One"},{"key":"2026102310071864800_bib24","doi-asserted-by":"publisher","first-page":"4134","DOI":"10.1128\/MCB.00154-10","article-title":"Myocardin-related transcription factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression","volume":"30","author":"Kuwahara","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"2026102310071864800_bib25","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1039\/c5ib00070j","article-title":"The mechanotransduction machinery at work at adherens junctions","volume":"7","author":"Ladoux","year":"2015","journal-title":"Integr. Biol. (Camb)"},{"key":"2026102310071864800_bib26","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.3892\/or.2014.3545","article-title":"P-cadherin potentiates ligand-dependent EGFR and IGF-1R signaling in dysplastic and malignant oral keratinocytes","volume":"32","author":"Lysne","year":"2014","journal-title":"Oncol. Rep."},{"key":"2026102310071864800_bib27","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1242\/jcs.047878","article-title":"Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility","volume":"123","author":"Martinez-Rico","year":"2010","journal-title":"J. Cell Sci."},{"key":"2026102310071864800_bib28","doi-asserted-by":"publisher","first-page":"4708","DOI":"10.1073\/pnas.1011123108","article-title":"Cell-ECM traction force modulates endogenous tension at cell-cell contacts","volume":"108","author":"Maruthamuthu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026102310071864800_bib29","doi-asserted-by":"publisher","first-page":"4769","DOI":"10.1038\/s41388-018-0304-2","article-title":"E-cadherin in contact inhibition and cancer","volume":"37","author":"Mendonsa","year":"2018","journal-title":"Oncogene"},{"key":"2026102310071864800_bib30","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1590\/s0100-879x2003000800018","article-title":"Changes in cell shape, cytoskeletal proteins and adhesion sites of cultured cells after extracellular Ca2+ chelation","volume":"36","author":"Mermelstein","year":"2003","journal-title":"Braz. J. Med. Biol. Res."},{"key":"2026102310071864800_bib31","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.devcel.2024.12.006","article-title":"The mechanical state of pre-tumoral epithelia controls subsequent Drosophila tumor aggressiveness","volume":"60","author":"Montemurro","year":"2025","journal-title":"Dev. Cell"},{"key":"2026102310071864800_bib32","doi-asserted-by":"publisher","first-page":"6622","DOI":"10.1093\/emboj\/17.22.6622","article-title":"Integrins induce activation of EGF receptor: Role in MAP kinase induction and adhesion-dependent cell survival","volume":"17","author":"Moro","year":"1998","journal-title":"EMBO J."},{"key":"2026102310071864800_bib33","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1242\/jcs.185447","article-title":"E-cadherin-mediated force transduction signals regulate global cell mechanics","volume":"129","author":"Muhamed","year":"2016","journal-title":"J. Cell Sci."},{"key":"2026102310071864800_bib34","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1440-169X.1994.00059.x","article-title":"The loss of the expression of alpha Catenin, the 102 kD cadherin associated protein, in central nervous tissues during development: (alpha catenin\/cadherin\/cell adhesion\/CNS)","volume":"36","author":"Nagafuchi","year":"1994","journal-title":"Dev. Growth Differ."},{"key":"2026102310071864800_bib35","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1083\/jcb.103.6.2649","article-title":"A novel cadherin cell adhesion molecule: Its expression patterns associated with implantation and organogenesis of mouse embryos","volume":"103","author":"Nose","year":"1986","journal-title":"J. Cell Biol."},{"key":"2026102310071864800_bib36","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1083\/jcb.201008173","article-title":"Evolution: Structural and functional diversity of cadherin at the adherens junction","volume":"193","author":"Oda","year":"2011","journal-title":"J. Cell Biol."},{"key":"2026102310071864800_bib37","doi-asserted-by":"publisher","DOI":"10.1101\/2025.04.28.651001","article-title":"Cellpose-SAM: Superhuman generalization for cellular segmentation","author":"Pachitariu","year":"2025","journal-title":"bioRxiv"},{"key":"2026102310071864800_bib38","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1002\/bies.201100086","article-title":"FRET microscopy in the living cell: Different approaches, strengths and weaknesses","volume":"34","author":"Padilla-Parra","year":"2012","journal-title":"Bioessays"},{"key":"2026102310071864800_bib55","doi-asserted-by":"publisher","first-page":"41227","DOI":"10.1074\/jbc.M006578200","article-title":"Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation","volume":"275","author":"Pece","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2026102310071864800_bib39","doi-asserted-by":"publisher","first-page":"4167","DOI":"10.1091\/mbc.02-05-0068","article-title":"Mutant actins demonstrate a role for unpolymerized actin in control of transcription by serum response factor","volume":"13","author":"Posern","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"2026102310071864800_bib40","doi-asserted-by":"publisher","first-page":"4326","DOI":"10.1038\/onc.2009.299","article-title":"Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage","volume":"28","author":"Provenzano","year":"2009","journal-title":"Oncogene"},{"key":"2026102310071864800_bib41","doi-asserted-by":"publisher","first-page":"jcs238840","DOI":"10.1242\/jcs.238840","article-title":"EGFR activation attenuates the mechanical threshold for integrin tension and focal adhesion formation","volume":"133","author":"Rao","year":"2020","journal-title":"J. Cell Sci."},{"key":"2026102310071864800_bib42","doi-asserted-by":"publisher","first-page":"19390","DOI":"10.1039\/c6nr04465d","article-title":"Atomic force microscopy and graph analysis to study the P-cadherin\/SFK mechanotransduction signalling in breast cancer cells","volume":"8","author":"Ribeiro","year":"2016","journal-title":"Nanoscale"},{"key":"2026102310071864800_bib43","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1002\/path.4143","article-title":"P-cadherin functional role is dependent on E-cadherin cellular context: A proof of concept using the breast cancer model","volume":"229","author":"Ribeiro","year":"2013","journal-title":"J. Pathol."},{"key":"2026102310071864800_bib44","doi-asserted-by":"publisher","first-page":"jcs206656","DOI":"10.1242\/jcs.206656","article-title":"Epidermal growth factor receptor and integrins control force-dependent vinculin recruitment to E-cadherin junctions","volume":"131","author":"Sehgal","year":"2018","journal-title":"J. Cell Sci."},{"key":"2026102310071864800_bib45","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1158\/0008-5472.CAN-19-3147","article-title":"Hybrid epithelial-mesenchymal phenotypes are controlled by microenvironmental factors","volume":"80","author":"Selvaggio","year":"2020","journal-title":"Cancer Res."},{"key":"2026102310071864800_bib46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2100679119","article-title":"Mechanical disruption of E-cadherin complexes with epidermal growth factor receptor actuates growth factor-dependent signaling","volume":"119","author":"Sullivan","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026102310071864800_bib47","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1126\/science.1086652","article-title":"Talin binding to integrin beta tails: A final common step in integrin activation","volume":"302","author":"Tadokoro","year":"2003","journal-title":"Science"},{"key":"2026102310071864800_bib48","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1158\/0008.5472.CAN-04-3646","article-title":"Overexpressed P-cadherin\/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases","volume":"65","author":"Taniuchi","year":"2005","journal-title":"Cancer Res."},{"key":"2026102310071864800_bib49","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.devcel.2023.02.015","article-title":"Identifying constitutive and context-specific molecular-tension-sensitive protein recruitment within focal adhesions","volume":"58","author":"Tao","year":"2023","journal-title":"Dev. Cell"},{"key":"2026102310071864800_bib50","doi-asserted-by":"publisher","first-page":"15237","DOI":"10.1038\/ncomms15237","article-title":"Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells","volume":"8","author":"Tavares","year":"2017","journal-title":"Nat. Commun."},{"key":"2026102310071864800_bib51","doi-asserted-by":"publisher","first-page":"111844","DOI":"10.1016\/j.isci.2025.111844","article-title":"P-cadherin-dependent adhesions are required for single lumen formation and HGF-mediated cell protrusions during epithelial morphogenesis","volume":"28","author":"Tran","year":"2025","journal-title":"iScience"},{"key":"2026102310071864800_bib52","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.devcel.2005.03.015","article-title":"Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion","volume":"8","author":"Wei","year":"2005","journal-title":"Dev. Cell"},{"key":"2026102310071864800_bib53","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1111\/j.0022-202X.2004.22328.x","article-title":"Mechanical stretching in vitro regulates signal transduction pathways and cellular proliferation in human epidermal keratinocytes","volume":"122","author":"Yano","year":"2004","journal-title":"J. Invest. Dermatol."},{"key":"2026102310071864800_bib54","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202000119","article-title":"Crosstalk between cell adhesion complexes in regulation of mechanotransduction","volume":"42","author":"Zuidema","year":"2020","journal-title":"Bioessays"}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.202511205\/2043077\/jcb_202511205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.202511205\/2043077\/jcb_202511205.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T14:08:58Z","timestamp":1792764538000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/226\/1\/e202511205\/283118\/Adhesion-integrity-activates-mechanosensitive"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1,4]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.202511205","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]},"article-number":"e202511205"}}