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How it does so remains unclear as probing mechanics during anaphase\u2019s short lifetime is challenging. Here, we use microneedles to pull on mammalian anaphase midzone bundles and ask how they respond to and transmit force across space and time. We find that midzone bundles locally transmit force to each other in the spindle\u2019s short axis over multiple timescales. Along the spindle\u2019s long axis, midzone bundles globally transmit force: rather than bundles sliding apart or detaching under force, the spindle shortens. This reveals strong anchorage and resistance to outward sliding, and that spindle elongation requires all midzone bundles to elongate. This global force transmission is stronger for short-lived forces and is strictly PRC1-dependent, indicating limited mechanistic redundancy. In sum, the anaphase spindle acts as a single mechanical unit over short timescales to resist and transmit force, while remodeling over long timescales to segregate chromosomes.<\/jats:p>","DOI":"10.1083\/jcb.202604150","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T14:02:39Z","timestamp":1792764159000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Midzone bundles of the mammalian anaphase spindle are mechanically coupled both locally and globally"],"prefix":"10.1083","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5661-1474","authenticated-orcid":true,"given":"Zachary","family":"Mullin-Bernstein","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"UCSF 1 Department of Bioengineering & Therapeutic Sciences, , San Francisco, CA,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"UCSF 2 Biomedical Sciences Graduate Program, , San Francisco, CA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1368-062X","authenticated-orcid":true,"given":"Sterre","family":"van Wierst","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"UCSF 1 Department of Bioengineering & Therapeutic Sciences, , San Francisco, CA,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/0575yy874","id-type":"ROR","asserted-by":"publisher"}],"name":"Utrecht University 3 Cancer, Stem Cells & Developmental Biology Master\u2019s Program, , Utrecht,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7763-6208","authenticated-orcid":true,"given":"Carly","family":"Garrison","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"UCSF 1 Department of Bioengineering & Therapeutic Sciences, , San Francisco, CA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0110-1343","authenticated-orcid":true,"given":"Nathan H.","family":"Cho","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"UCSF 1 Department of Bioengineering & Therapeutic Sciences, , San Francisco, CA,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"UCSF 4 Tetrad Graduate Program, , San Francisco, CA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8283-1523","authenticated-orcid":true,"given":"Sophie","family":"Dumont","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"UCSF 1 Department of Bioengineering & Therapeutic Sciences, , San Francisco, CA,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"UCSF 2 Biomedical Sciences Graduate Program, , San Francisco, CA,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"UCSF 4 Tetrad Graduate Program, , San Francisco, CA,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"UCSF 5 Department of Biochemistry & Biophysics, , San Francisco, CA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"2026102310023100900_bib1","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1242\/jcs.104.4.1207","article-title":"Astral and spindle forces in PtK2 cells during anaphase B: A laser microbeam study","volume":"104","author":"Aist","year":"1993","journal-title":"J. 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