{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:44:09Z","timestamp":1791074649924,"version":"4.1.0"},"reference-count":81,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,10,6]]},"abstract":"<jats:p>Three hallmark features of the cardiac hypertrophic growth program are increases in cell size, sarcomeric organization, and the induction of certain cardiac-specific genes. All three features of hypertrophy are induced in cultured myocardial cells by \u03b11- adrenergic receptor agonists, such as phenylephrine (PE) and other growth factors that activate mitogen- activated protein kinases (MAPKs). In this study the MAPK family members extracellular signal\u2013regulated kinase (ERK), c-jun NH2-terminal kinase (JNK), and p38 were activated by transfecting cultured cardiac myocytes with constructs encoding the appropriate kinases possessing gain-of-function mutations. Transfected cells were then analyzed for changes in cell size, sarcomeric organization, and induction of the genes for the A- and B-type natriuretic peptides (NPs), as well as the \u03b1-skeletal actin (\u03b1-SkA) gene. While activation of JNK and\/or ERK with MEKK1COOH or Raf-1 BXB, respectively, augmented cell size and effected relatively modest increases in NP and \u03b1-SkA promoter activities, neither upstream kinase conferred sarcomeric organization. However, transfection with MKK6 (Glu), which specifically activated p38, augmented cell size, induced NP and \u03b1-Ska promoter activities by up to 130-fold, and elicited sarcomeric organization in a manner similar to PE. Moreover, all three growth features induced by MKK6 (Glu) or PE were blocked with the p38-specific inhibitor, SB 203580. These results demonstrate novel and potentially central roles for MKK6 and p38 in the regulation of myocardial cell hypertrophy.<\/jats:p>","DOI":"10.1083\/jcb.139.1.115","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:47:50Z","timestamp":1027702070000},"page":"115-127","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":255,"title":["A Role for the p38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression"],"prefix":"10.1083","volume":"139","author":[{"given":"Dietmar","family":"Zechner","sequence":"first","affiliation":[{"name":"Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, California 92182"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna J.","family":"Thuerauf","sequence":"additional","affiliation":[{"name":"Department of Biology and 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hearts","volume":"269","author":"Clerk","year":"1994","journal-title":"J Biol Chem"},{"key":"2023072209312307300_B12","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1091\/mbc.2.12.965","article-title":"Extracellular signal-regulated kinases: ERKs in progress","volume":"2","author":"Cobb","year":"1991","journal-title":"Cell Regul"},{"key":"2023072209312307300_B13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0014-5793(95)00357-F","article-title":"SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1","volume":"364","author":"Cuenda","year":"1995","journal-title":"FEBS Lett"},{"key":"2023072209312307300_B14","first-page":"4293","article-title":"Purification and cDNA cloning of SAPKK3, the major activator of RK\/p38 in stress- and cytokine-stimulated monocytes and epithelial cells","volume":"15","author":"Cuenda","year":"1996","journal-title":"EMBO (Eur Mol Biol Organ) 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Heat shock protein 27 blocks Fas\/APO-1- and staurosporine-induced cell death","volume":"271","author":"Mehlen","year":"1996","journal-title":"J Biol Chem"},{"key":"2023072209312307300_B49","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/0008-6363(96)00078-8","article-title":"Norepinephrine induces cardiac heat shock protein 70 and delayed cardioprotection in the rat through alpha 1 adrenoreceptors","volume":"32","author":"Meng","year":"1996","journal-title":"Cardiovasc Res"},{"key":"2023072209312307300_B50","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1172\/JCI117030","article-title":"Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury","volume":"93","author":"Mestril","year":"1994","journal-title":"J Clin Invest"},{"key":"2023072209312307300_B51","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1126\/science.7992057","article-title":"Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK","volume":"266","author":"Minden","year":"1994","journal-title":"Science (Wash DC)"},{"key":"2023072209312307300_B52","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"2023072209312307300_B53","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1126\/science.272.5262.671","article-title":"Molecular pathways controlling heart development","volume":"272","author":"Olson","year":"1996","journal-title":"Science (Wash DC)"},{"key":"2023072209312307300_B54","doi-asserted-by":"crossref","first-page":"10827","DOI":"10.1074\/jbc.271.18.10827","article-title":"Serum response factor mediates AP-1-dependent induction of the skeletal \u03b1-actin promoter in ventricular myocytes","volume":"271","author":"Paradis","year":"1996","journal-title":"J Biol Chem"},{"key":"2023072209312307300_B55","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0165-6147(94)90129-5","article-title":"Proction of the heart by ischaemic preconditioning: mechanisms and possibilities for pharmacological exploitation","volume":"15","author":"Parratt","year":"1994","journal-title":"Trends Pharmacol Sci"},{"key":"2023072209312307300_B56","doi-asserted-by":"crossref","first-page":"8452","DOI":"10.1074\/jbc.271.14.8452","article-title":"Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ventricular myocytes","volume":"271","author":"Post","year":"1996","journal-title":"J Biol Chem"},{"key":"2023072209312307300_B57","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.1074\/jbc.270.13.7420","article-title":"Pro-inflammatory cytokines and environmental stress cause p38 MAP kinase activation by dual phosphorylation on tyrosine and threonine","volume":"270","author":"Raingeaud","year":"1995","journal-title":"J Biol Chem"},{"key":"2023072209312307300_B58","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1128\/MCB.16.3.1247","article-title":"MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway","volume":"16","author":"Raingeaud","year":"1996","journal-title":"Mol Cell Biol"},{"key":"2023072209312307300_B59","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/0092-8674(94)90277-1","article-title":"A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins","volume":"78","author":"Rouse","year":"1994","journal-title":"Cell"},{"key":"2023072209312307300_B60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.76.1.1","article-title":"Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca2+-dependent signaling","volume":"76","author":"Sadoshima","year":"1995","journal-title":"Circ Res"},{"key":"2023072209312307300_B61","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/excr.1996.0070","article-title":"Heat shock proteins increase resistance to apoptosis","volume":"223","author":"Samali","year":"1996","journal-title":"Exp Cell Res"},{"key":"2023072209312307300_B62","first-page":"33","article-title":"Growth factors, growth factor response elements, and the cardiac phenotype","volume":"87","author":"Schneider","year":"1992","journal-title":"Basic Res Cardiol"},{"key":"2023072209312307300_B63"},{"key":"2023072209312307300_B64","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1172\/JCI111023","article-title":"Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an \u03b11-adrenergic response","volume":"72","author":"Simpson","year":"1983","journal-title":"J Clin Invest"},{"key":"2023072209312307300_B65","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1128\/MCB.16.3.868","article-title":"3pK, a new mitogen-activated protein kinase, located in the small cell lung cancer tumor suppressor gene region","volume":"16","author":"Sithanandam","year":"1996","journal-title":"Mol Cell Biol"},{"key":"2023072209312307300_B66","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1161\/01.RES.77.6.1060","article-title":"Involvement of multiple cis elements in basal- and \u03b1-adrenergic agonist-inducible atrial natriuretic factor transcription. 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