{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:38:43Z","timestamp":1770503923544,"version":"3.49.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1962,12,1]]},"abstract":"<jats:p>The electron microscope has been used to determine the weight distribution of isolated subcellular particles from normal rat liver. The following results are reported: (1) There exist at least two well defined weight populations of subcellular particles; their respective median weights are 1.3 x 10-14 and 11 x 10-14 gm. The lighter fraction is considered to consist of lysosomes, the heavier of mitochondria. (2) The mitochondrial fraction shows a log-normal distribution of the particle weight. (3) By the introduction of morphologic criteria, the mitochondrial fraction is divided into two groups, one consisting of a spherical, the other of an oblong type of particle. The data found support the following concepts: (a) Mitochondria increase their weight from a certain size up by linear growth. (b) Mitochondria divide. The division is not necessarily symmetric; in all cases, however, one part of the division product is a spherical particle. It is felt that these results constitute a valuable demonstration of the general capabilities of quantitative electron microscopy and may stimulate many other useful applications of this technique in cytology, bacteriology, and virology.<\/jats:p>","DOI":"10.1083\/jcb.15.3.489","type":"journal-article","created":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T17:40:25Z","timestamp":1084556425000},"page":"489-501","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["STUDY OF MITOCHONDRIA IN RAT LIVER"],"prefix":"10.1083","volume":"15","author":[{"given":"Gunter F.","family":"Bahr","sequence":"first","affiliation":[{"name":"From the Armed Forces Institute of Pathology, Washington, D. C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elmar","family":"Zeitler","sequence":"additional","affiliation":[{"name":"From the Armed Forces Institute of Pathology, Washington, D. C."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1962,12,1]]},"container-title":["The Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/15\/3\/489\/1505383\/489.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/15\/3\/489\/1505383\/489.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T09:46:54Z","timestamp":1690019214000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/15\/3\/489\/16169\/STUDY-OF-MITOCHONDRIA-IN-RAT-LIVER-Quantitative"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1962,12,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1962,12,1]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.15.3.489","relation":{},"ISSN":["1540-8140","0021-9525"],"issn-type":[{"value":"1540-8140","type":"electronic"},{"value":"0021-9525","type":"print"}],"subject":[],"published":{"date-parts":[[1962,12,1]]}}}