{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T19:21:03Z","timestamp":1769282463532,"version":"3.49.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,4,1]]},"abstract":"<jats:p>Primary embryonic fibroblasts isolated from beige (Chediak-Higashi) mice develop pathognomonic giant granules in vitro. Inclusion in the culture medium of carbamylcholine (carbachol) or phorbol myristate acetate (PMA) results in the generation of morphologically normally granules. Chediak-Higashi fibroblasts are highly susceptible to shape changes induced by colchicine. This abnormal property is also corrected by carbachol and PMA.<\/jats:p>","DOI":"10.1083\/jcb.69.1.205","type":"journal-article","created":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T23:04:59Z","timestamp":1084575899000},"page":"205-210","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Carbamycholine prevents giant granule-formation in cultured fibroblasts from beige (Chediak-Higashi) mice."],"prefix":"10.1083","volume":"69","author":[{"given":"J M","family":"Oliver","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Krawiec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R D","family":"Berlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1976,4,1]]},"container-title":["The Journal of cell biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/69\/1\/205\/1631631\/205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/69\/1\/205\/1631631\/205.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T07:24:59Z","timestamp":1690183499000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/69\/1\/205\/20209\/Carbamycholine-prevents-giant-granule-formation-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,4,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1976,4,1]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.69.1.205","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,4,1]]}}}