{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:11:32Z","timestamp":1768011092860,"version":"3.49.0"},"reference-count":66,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,1,16]]},"abstract":"<jats:p>In the yeast Saccharomyces cerevisiae that lacks lamins, the nuclear pore complex (NPC) has been proposed to serve a role in chromatin organization. Here, using fluorescence microscopy in living cells, we show that nuclear pore proteins of the Nup84 core complex, Nup84p, Nup145Cp, Nup120p, and Nup133p, serve to anchor telomere XI-L at the nuclear periphery. The integrity of this complex is shown to be required for repression of a URA3 gene inserted in the subtelomeric region of this chromosome end. Furthermore, altering the integrity of this complex decreases the efficiency of repair of a DNA double-strand break (DSB) only when it is generated in the subtelomeric region, even though the repair machinery is functional. These effects are specific to the Nup84 complex. Our observations thus confirm and extend the role played by the NPC, through the Nup84 complex, in the functional organization of chromatin. They also indicate that anchoring of telomeres is essential for efficient repair of DSBs occurring therein and is important for preserving genome integrity.<\/jats:p>","DOI":"10.1083\/jcb.200505159","type":"journal-article","created":{"date-parts":[[2006,1,17]],"date-time":"2006-01-17T23:28:02Z","timestamp":1137540482000},"page":"189-199","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":182,"title":["Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region"],"prefix":"10.1083","volume":"172","author":[{"given":"Pierre","family":"Therizols","sequence":"first","affiliation":[{"name":"1Unite\u0301 de Ge\u0301ne\u0301tique Mole\u0301culaire des Levures (URA 2171 Centre National de la Recherche Scientifique, UFR 927 Universite\u0301 Pierre et Marie Curie), De\u0301partement Structure et Dynamique des Ge\u0301nomes, Institut Pasteur, 75724 Paris Cedex, France"}]},{"given":"Ce\u0301cile","family":"Fairhead","sequence":"additional","affiliation":[{"name":"1Unite\u0301 de Ge\u0301ne\u0301tique Mole\u0301culaire des Levures (URA 2171 Centre National de la Recherche Scientifique, UFR 927 Universite\u0301 Pierre et Marie Curie), De\u0301partement Structure et Dynamique des Ge\u0301nomes, Institut Pasteur, 75724 Paris Cedex, France"}]},{"given":"Ghislain G.","family":"Cabal","sequence":"additional","affiliation":[{"name":"2Unite\u0301 de Biologie Cellulaire du Noyau, De\u0301partement Biologie Cellulaire et Infection, Institut Pasteur, 75724 Paris Cedex, France"}]},{"given":"Auguste","family":"Genovesio","sequence":"additional","affiliation":[{"name":"3Unite\u0301 d'Analyse d'Images Quantitative, De\u0301partement Biologie Cellulaire et Infection, Institut Pasteur, 75724 Paris Cedex, France"}]},{"given":"Jean-Christophe","family":"Olivo-Marin","sequence":"additional","affiliation":[{"name":"3Unite\u0301 d'Analyse d'Images Quantitative, De\u0301partement Biologie Cellulaire et Infection, Institut Pasteur, 75724 Paris Cedex, France"}]},{"given":"Bernard","family":"Dujon","sequence":"additional","affiliation":[{"name":"1Unite\u0301 de Ge\u0301ne\u0301tique Mole\u0301culaire des Levures (URA 2171 Centre National de la Recherche Scientifique, UFR 927 Universite\u0301 Pierre et Marie Curie), De\u0301partement Structure et Dynamique des Ge\u0301nomes, Institut Pasteur, 75724 Paris Cedex, France"}]},{"given":"Emmanuelle","family":"Fabre","sequence":"additional","affiliation":[{"name":"1Unite\u0301 de Ge\u0301ne\u0301tique Mole\u0301culaire des Levures (URA 2171 Centre National de la Recherche Scientifique, UFR 927 Universite\u0301 Pierre et Marie Curie), De\u0301partement Structure et Dynamique des Ge\u0301nomes, Institut Pasteur, 75724 Paris Cedex, France"}]}],"member":"291","published-online":{"date-parts":[[2006,1,17]]},"reference":[{"key":"2023072907211041000_BIB1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/29100","volume":"394","year":"1998","journal-title":"Nature."},{"key":"2023072907211041000_BIB2","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1128\/MCB.22.23.8292-8301.2002","volume":"22","year":"2002","journal-title":"Mol. 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