{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:18:55Z","timestamp":1774264735166,"version":"3.50.1"},"reference-count":58,"publisher":"Rockefeller University Press","issue":"7","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,3,27]]},"abstract":"<jats:p>The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. Current interest in this process, which is described as an epithelial\u2013mesenchymal transition (EMT), stems from its developmental importance and its involvement in several adult pathologies. Interest and research in EMT are currently at a high level, as seen by the attendance at the recent EMT meeting in Vancouver, Canada (October 1\u20133, 2005). The meeting, which was hosted by The EMT International Association, was the second international EMT meeting, the first being held in Port Douglas, Queensland, Australia in October 2003. The EMT International Association was formed in 2002 to provide an international body for those interested in EMT and the reverse process, mesenchymal\u2013epithelial transition, and, most importantly, to bring together those working on EMT in development, cancer, fibrosis, and pathology. These themes continued during the recent meeting in Vancouver.<\/jats:p>\n               <jats:p>Discussion at the Vancouver meeting spanned several areas of research, including signaling pathway activation of EMT and the transcription factors and gene targets involved. Also covered in detail was the basic cell biology of EMT and its role in cancer and fibrosis, as well as the identification of new markers to facilitate the observation of EMT in vivo. This is particularly important because the potential contribution of EMT during neoplasia is the subject of vigorous scientific debate (Tarin, D., E.W. Thompson, and D.F. Newgreen. 2005. Cancer Res. 65:5996\u20136000; Thompson, E.W., D.F. Newgreen, and D. Tarin. 2005. Cancer Res. 65:5991\u20135995).<\/jats:p>","DOI":"10.1083\/jcb.200601018","type":"journal-article","created":{"date-parts":[[2006,3,27]],"date-time":"2006-03-27T20:02:59Z","timestamp":1143489779000},"page":"973-981","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":1614,"title":["The epithelial\u2013mesenchymal transition: new insights in signaling, development, and disease"],"prefix":"10.1083","volume":"172","author":[{"given":"Jonathan M.","family":"Lee","sequence":"first","affiliation":[{"name":"1Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada"}]},{"given":"Shoukat","family":"Dedhar","sequence":"additional","affiliation":[{"name":"2Department of Biochemistry, University of British Columbia, Vancouver, British Columbia V57 1L3, Canada"},{"name":"3British Columbia Cancer and Research Centre at the British Columbia Cancer Agency, Vancouver, British Columbia V57 1L3, Canada"}]},{"given":"Raghu","family":"Kalluri","sequence":"additional","affiliation":[{"name":"4Department of Medicine, Center for Matrix Biology, Beth Israel Deaconess Medical Center"},{"name":"5Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215"},{"name":"6Harvard\u2013Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA 02139"}]},{"given":"Erik W.","family":"Thompson","sequence":"additional","affiliation":[{"name":"7Department of Surgery, University of Melbourne, St. Vincent's Hospital, Fitzroy, 3065, Australia"},{"name":"8St. Vincent's Institute of Medical Research, Fitzroy, 3065, Australia"}]}],"member":"291","published-online":{"date-parts":[[2006,3,27]]},"reference":[{"key":"2023072910062810000_BIB1","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1242\/dev.01907","volume":"132","year":"2005","journal-title":"Development."},{"key":"2023072910062810000_BIB2","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.4161\/cc.4.10.2053","volume":"4","year":"2005","journal-title":"Cell Cycle."},{"key":"2023072910062810000_BIB3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jss.400060102","volume":"6","year":"1977","journal-title":"J. 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