{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:37:54Z","timestamp":1775158674589,"version":"3.50.1"},"reference-count":52,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,4,6]]},"abstract":"<jats:p>During development, Schwann cells (SCs) interpret different extracellular cues to regulate their migration, proliferation, and the remarkable morphological changes associated with the sorting, ensheathment, and myelination of axons. Although interactions between extracellular matrix proteins and integrins are critical to some of these processes, the downstream signaling pathways they control are still poorly understood. Integrin-linked kinase (ILK) is a focal adhesion protein that associates with multiple binding partners to link integrins to the actin cytoskeleton and is thought to participate in integrin and growth factor\u2013mediated signaling. Using SC-specific gene ablation, we report essential functions for ILK in radial sorting of axon bundles and in remyelination in the peripheral nervous system. Our in vivo and in vitro experiments show that ILK negatively regulates Rho\/Rho kinase signaling to promote SC process extension and to initiate radial sorting. ILK also facilitates axon remyelination, likely by promoting the activation of downstream molecules such as AKT\/protein kinase B.<\/jats:p>","DOI":"10.1083\/jcb.200809008","type":"journal-article","created":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T20:19:16Z","timestamp":1239049156000},"page":"147-161","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":106,"title":["Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system"],"prefix":"10.1083","volume":"185","author":[{"given":"Jorge A.","family":"Pereira","sequence":"first","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland 1"}]},{"given":"Yves","family":"Benninger","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland 1"}]},{"given":"Reto","family":"Baumann","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland 1"}]},{"given":"Ana Filipa","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland 1"},{"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto, 4150-180 Porto, Portugal 2"}]},{"given":"Murat","family":"\u00d6z\u00e7elik","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland 1"}]},{"given":"Tina","family":"Thurnherr","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland 1"}]},{"given":"Nicolas","family":"Tricaud","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland 1"}]},{"given":"Dies","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Genetics, Erasmus MC University Medical Centre, 3000 DR Rotterdam, Netherlands 3"}]},{"given":"Reinhard","family":"F\u00e4ssler","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Max Planck Institute of Biochemistry, D-82152 Martinsried, Germany 4"}]},{"given":"Ueli","family":"Suter","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland 1"}]},{"given":"Jo\u00e3o B.","family":"Relvas","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland 1"},{"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto, 4150-180 Porto, Portugal 2"}]}],"member":"291","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"2023072915413866000_bib1","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1523\/JNEUROSCI.4594-05.2006","article-title":"ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury","volume":"26","author":"Atanasoski","year":"2006","journal-title":"J. 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