{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:28:41Z","timestamp":1772137721315,"version":"3.50.1"},"reference-count":78,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,4,4]]},"abstract":"<jats:p>The chromosomal passenger complex (CPC) and centralspindlin are conserved cytokinesis regulators that localize to the spindle midzone, which forms between the separating chromosomes. Previous work placed the CPC and centralspindlin in a linear pathway that governs midzone formation. Using Caenorhabditis elegans embryos, we test whether there is a similar linear relationship between centralspindlin and the CPC in contractile ring constriction during cytokinesis. We show that simultaneous inhibition of the CPC kinase Aurora BAIR-2 and the centralspindlin component MKLP1ZEN-4 causes an additive constriction defect. Consistent with distinct roles for the proteins, inhibition of filamentous septin guanosine triphosphatases alleviates constriction defects in Aurora BAIR-2\u2013inhibited embryos, whereas inhibition of Rac does so in MKLP1ZEN-4-inhibited embryos. Centralspindlin and the CPC are not required to enrich ring proteins at the cell equator but instead regulate formation of a compact mature ring. Therefore, in contrast to the linear midzone assembly pathway, centralspindlin and the CPC make independent contributions to control transformation of the sheet-like equatorial band into a ribbon-like contractile ring at the furrow tip.<\/jats:p>","DOI":"10.1083\/jcb.201008138","type":"journal-article","created":{"date-parts":[[2011,4,4]],"date-time":"2011-04-04T12:59:55Z","timestamp":1301921995000},"page":"155-169","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly"],"prefix":"10.1083","volume":"193","author":[{"given":"Lindsay","family":"Lewellyn","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Biomedical Sciences Graduate Program, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093 1"}]},{"given":"Ana","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Biomedical Sciences Graduate Program, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093 1"}]},{"given":"Arshad","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Biomedical Sciences Graduate Program, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093 1"}]},{"given":"Amy S.","family":"Maddox","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Institute for Research in Immunology and Cancer, University of Montr\u00e9al, Montr\u00e9al, Quebec H3C 3J7, Canada 2"}]},{"given":"Karen","family":"Oegema","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Biomedical Sciences Graduate Program, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093 1"}]}],"member":"291","published-online":{"date-parts":[[2011,4,4]]},"reference":[{"key":"2023072301053679300_bib1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ceb.2007.12.001","article-title":"Structural insights shed light onto septin assemblies and function","volume":"20","author":"Barral","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072301053679300_bib2","doi-asserted-by":"publisher","first-page":"e409","DOI":"10.1371\/journal.pone.0000409","article-title":"Polo-like kinase controls vertebrate spindle elongation and cytokinesis","volume":"2","author":"Brennan","year":"2007","journal-title":"PLoS ONE."},{"key":"2023072301053679300_bib3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics."},{"key":"2023072301053679300_bib4","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.1073\/pnas.0701140104","article-title":"Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells","volume":"104","author":"Burkard","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072301053679300_bib5","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S0960-9822(00)00490-5","article-title":"The role of pre- and post-anaphase microtubules in the cytokinesis phase of the cell cycle","volume":"10","author":"Canman","year":"2000","journal-title":"Curr. Biol."},{"key":"2023072301053679300_bib6","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1126\/science.1163086","article-title":"Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis","volume":"322","author":"Canman","year":"2008","journal-title":"Science."},{"key":"2023072301053679300_bib7","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1042\/BST0360367","article-title":"Cytokinesis: the final stop for the chromosomal passengers","volume":"36","author":"Carmena","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"2023072301053679300_bib8","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.ceb.2009.09.008","article-title":"Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins","volume":"21","author":"Carmena","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072301053679300_bib9","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.cell.2009.03.021","article-title":"Structural memory in the contractile ring makes the duration of cytokinesis independent of cell size","volume":"137","author":"Carvalho","year":"2009","journal-title":"Cell."},{"key":"2023072301053679300_bib10","doi-asserted-by":"publisher","first-page":"4051","DOI":"10.1091\/mbc.E03-04-0247","article-title":"The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast","volume":"14","author":"Caviston","year":"2003","journal-title":"Mol. Biol. Cell."},{"key":"2023072301053679300_bib11","doi-asserted-by":"publisher","first-page":"4770","DOI":"10.1242\/jcs.03235","article-title":"Kinesin 6 family member Subito participates in mitotic spindle assembly and interacts with mitotic regulators","volume":"119","author":"Cesario","year":"2006","journal-title":"J. Cell Sci."},{"key":"2023072301053679300_bib12","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.1242\/jcs.03032","article-title":"Influence of human Ect2 depletion and overexpression on cleavage furrow formation and abscission","volume":"119","author":"Chalamalasetty","year":"2006","journal-title":"J. Cell Sci."},{"key":"2023072301053679300_bib13","doi-asserted-by":"publisher","first-page":"e209","DOI":"10.1371\/journal.pbio.0060209","article-title":"Redundant mechanisms recruit actin into the contractile ring in silkworm spermatocytes","volume":"6","author":"Chen","year":"2008","journal-title":"PLoS Biol."},{"key":"2023072301053679300_bib14","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1242\/jcs.034785","article-title":"How to scaffold the contractile ring for a safe cytokinesis - lessons from Anillin-related proteins","volume":"122","author":"D\u2019Avino","year":"2009","journal-title":"J. Cell Sci."},{"key":"2023072301053679300_bib15","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/ncb0209-112","article-title":"Cytokinesis: mind the GAP","volume":"11","author":"D\u2019Avino","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"2023072301053679300_bib16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1083\/jcb.200402157","article-title":"Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac","volume":"166","author":"D\u2019Avino","year":"2004","journal-title":"J. Cell Biol."},{"key":"2023072301053679300_bib17","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1242\/jcs.02335","article-title":"Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy","volume":"118","author":"D\u2019Avino","year":"2005","journal-title":"J. Cell Sci."},{"key":"2023072301053679300_bib18","doi-asserted-by":"publisher","first-page":"4402","DOI":"10.1242\/jcs.03210","article-title":"RacGAP50C is sufficient to signal cleavage furrow formation during cytokinesis","volume":"119","author":"D\u2019Avino","year":"2006","journal-title":"J. Cell Sci."},{"key":"2023072301053679300_bib19","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S1534-5807(03)00061-3","article-title":"Phosphorylation-dependent regulation of septin dynamics during the cell cycle","volume":"4","author":"Dobbelaere","year":"2003","journal-title":"Dev. Cell."},{"key":"2023072301053679300_bib20","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.cub.2010.03.055","article-title":"Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis","volume":"20","author":"Douglas","year":"2010","journal-title":"Curr. Biol."},{"key":"2023072301053679300_bib21","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1146\/annurev.biochem.74.082803.133425","article-title":"Animal cytokinesis: from parts list to mechanisms","volume":"75","author":"Eggert","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"2023072301053679300_bib22","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1083\/jcb.200807128","article-title":"Stable and dynamic microtubules coordinately shape the myosin activation zone during cytokinetic furrow formation","volume":"183","author":"Foe","year":"2008","journal-title":"J. Cell Biol."},{"key":"2023072301053679300_bib23","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1242\/dev.127.9.1767","article-title":"Microtubules and mitotic cycle phase modulate spatiotemporal distributions of F-actin and myosin II in Drosophila syncytial blastoderm embryos","volume":"127","author":"Foe","year":"2000","journal-title":"Development."},{"key":"2023072301053679300_bib24","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1083\/jcb.200404001","article-title":"Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle","volume":"166","author":"Gassmann","year":"2004","journal-title":"J. Cell Biol."},{"key":"2023072301053679300_bib25","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1083\/jcb.152.4.669","article-title":"Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis","volume":"152","author":"Giet","year":"2001","journal-title":"J. Cell Biol."},{"key":"2023072301053679300_bib26","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1126\/science.1096896","article-title":"The molecular requirements for cytokinesis","volume":"307","author":"Glotzer","year":"2005","journal-title":"Science."},{"key":"2023072301053679300_bib27","doi-asserted-by":"publisher","first-page":"R162","DOI":"10.1016\/j.cub.2008.12.028","article-title":"Cytokinesis: GAP gap","volume":"19","author":"Glotzer","year":"2009","journal-title":"Curr. Biol."},{"key":"2023072301053679300_bib28","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.cub.2005.03.041","article-title":"Phosphorylation of ZEN-4\/MKLP1 by aurora B regulates completion of cytokinesis","volume":"15","author":"Guse","year":"2005","journal-title":"Curr. Biol."},{"key":"2023072301053679300_bib29","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1083\/jcb.200208092","article-title":"The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint","volume":"161","author":"Hauf","year":"2003","journal-title":"J. Cell Biol."},{"key":"2023072301053679300_bib30","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1083\/jcb.149.7.1391","article-title":"CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis","volume":"149","author":"Jantsch-Plunger","year":"2000","journal-title":"J. Cell Biol."},{"key":"2023072301053679300_bib31","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1016\/S0960-9822(00)00721-1","article-title":"Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis","volume":"10","author":"Kaitna","year":"2000","journal-title":"Curr. Biol."},{"key":"2023072301053679300_bib32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1091\/mbc.E05-06-0569","article-title":"Dissecting the role of Rho-mediated signaling in contractile ring formation","volume":"17","author":"Kamijo","year":"2006","journal-title":"Mol. Biol. Cell."},{"key":"2023072301053679300_bib33","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1038\/sj.emboj.7600347","article-title":"Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation","volume":"23","author":"Kurasawa","year":"2004","journal-title":"EMBO J."},{"key":"2023072301053679300_bib34","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1091\/mbc.E09-01-0089","article-title":"Analyzing the effects of delaying aster separation on furrow formation during cytokinesis in the Caenorhabditis elegans embryo","volume":"21","author":"Lewellyn","year":"2010","journal-title":"Mol. Biol. Cell."},{"key":"2023072301053679300_bib35","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.devcel.2007.02.018","article-title":"Anillin and the septins promote asymmetric ingression of the cytokinetic furrow","volume":"12","author":"Maddox","year":"2007","journal-title":"Dev. Cell."},{"key":"2023072301053679300_bib36","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.tcb.2005.05.004","article-title":"Regulation of myosin II during cytokinesis in higher eukaryotes","volume":"15","author":"Matsumura","year":"2005","journal-title":"Trends Cell Biol."},{"key":"2023072301053679300_bib37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/ncb1814","article-title":"Regulation of cytokinesis by Rho GTPase flux","volume":"11","author":"Miller","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"2023072301053679300_bib38","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S1534-5807(03)00089-3","article-title":"Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis","volume":"4","author":"Minoshima","year":"2003","journal-title":"Dev. Cell."},{"key":"2023072301053679300_bib39","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1091\/mbc.E04-04-0346","article-title":"Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not","volume":"16","author":"Mollinari","year":"2005","journal-title":"Mol. Biol. Cell."},{"key":"2023072301053679300_bib40","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/ncb1459","article-title":"Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos","volume":"8","author":"Motegi","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"2023072301053679300_bib41","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/oxfordjournals.jbchem.a022840","article-title":"Myosin II regulatory light chain as a novel substrate for AIM-1, an aurora\/Ipl1p-related kinase from rat","volume":"128","author":"Murata-Hori","year":"2000","journal-title":"J. Biochem."},{"key":"2023072301053679300_bib42","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1242\/jcs.02737","article-title":"Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis","volume":"119","author":"Nishimura","year":"2006","journal-title":"J. Cell Sci."},{"key":"2023072301053679300_bib43","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1074\/mcp.M900308-MCP200","article-title":"Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition","volume":"9","author":"Ozl\u00fc","year":"2010","journal-title":"Mol. Cell. Proteomics."},{"key":"2023072301053679300_bib44","doi-asserted-by":"publisher","first-page":"4992","DOI":"10.1091\/mbc.E07-05-0468","article-title":"Cooperative assembly of CYK-4\/MgcRacGAP and ZEN-4\/MKLP1 to form the centralspindlin complex","volume":"18","author":"Pavicic-Kaltenbrunner","year":"2007","journal-title":"Mol. Biol. Cell."},{"key":"2023072301053679300_bib45","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.devcel.2007.03.013","article-title":"Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle","volume":"12","author":"Petronczki","year":"2007","journal-title":"Dev. Cell."},{"key":"2023072301053679300_bib46","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1242\/jcs.115.11.2271","article-title":"Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo","volume":"115","author":"Piekny","year":"2002","journal-title":"J. Cell Sci."},{"key":"2023072301053679300_bib47","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/S0960-9822(98)70470-1","article-title":"A nematode kinesin required for cleavage furrow advancement","volume":"8","author":"Powers","year":"1998","journal-title":"Curr. Biol."},{"key":"2023072301053679300_bib48","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1101\/gad.13.17.2301","article-title":"A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila","volume":"13","author":"Prokopenko","year":"1999","journal-title":"Genes Dev."},{"key":"2023072301053679300_bib49","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1091\/mbc.9.8.2037","article-title":"Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4","volume":"9","author":"Raich","year":"1998","journal-title":"Mol. Biol. Cell."},{"key":"2023072301053679300_bib50","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1091\/mbc.E04-08-0734","article-title":"Actin and septin ultrastructures at the budding yeast cell cortex","volume":"16","author":"Rodal","year":"2005","journal-title":"Mol. Biol. Cell."},{"key":"2023072301053679300_bib51","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1083\/jcb.200110045","article-title":"The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis","volume":"157","author":"Rogers","year":"2002","journal-title":"J. Cell Biol."},{"key":"2023072301053679300_bib52","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1083\/jcb.200207117","article-title":"CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1","volume":"161","author":"Romano","year":"2003","journal-title":"J. Cell Biol."},{"key":"2023072301053679300_bib53","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1038\/nrm2257","article-title":"Chromosomal passengers: conducting cell division","volume":"8","author":"Ruchaud","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023072301053679300_bib54","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1083\/jcb.53.2.419","article-title":"The contractile ring. II. Determining its brief existence, volumetric changes, and vital role in cleaving Arbacia eggs","volume":"53","author":"Schroeder","year":"1972","journal-title":"J. Cell Biol."},{"key":"2023072301053679300_bib55","first-page":"305","article-title":"Dynamics of the contractile ring","volume":"30","author":"Schroeder","year":"1975","journal-title":"Soc. Gen. Physiol. Ser."},{"key":"2023072301053679300_bib56","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1083\/jcb.143.6.1635","article-title":"AIR-2: An Aurora\/Ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos","volume":"143","author":"Schumacher","year":"1998","journal-title":"J. Cell Biol."},{"key":"2023072301053679300_bib57","doi-asserted-by":"crossref","first-page":"13137","DOI":"10.1016\/S0021-9258(18)43018-9","article-title":"Reversible phosphorylation of smooth muscle myosin, heavy meromyosin, and platelet myosin","volume":"256","author":"Sellers","year":"1981","journal-title":"J. Biol. Chem."},{"key":"2023072301053679300_bib58","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1083\/jcb.101.5.1897","article-title":"Light chain phosphorylation regulates the movement of smooth muscle myosin on actin filaments","volume":"101","author":"Sellers","year":"1985","journal-title":"J. Cell Biol."},{"key":"2023072301053679300_bib59","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1016\/S0960-9822(00)00715-6","article-title":"The aurora-related kinase AIR-2 recruits ZEN-4\/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis","volume":"10","author":"Severson","year":"2000","journal-title":"Curr. Biol."},{"key":"2023072301053679300_bib60","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/S0960-9822(02)00838-2","article-title":"Transitions regulating the timing of cytokinesis in embryonic cells","volume":"12","author":"Shuster","year":"2002","journal-title":"Curr. Biol."},{"key":"2023072301053679300_bib61","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S1097-2765(00)00023-X","article-title":"The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone","volume":"6","author":"Speliotes","year":"2000","journal-title":"Mol. Cell."},{"key":"2023072301053679300_bib62","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1126\/science.1081412","article-title":"Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor","volume":"299","author":"Straight","year":"2003","journal-title":"Science."},{"key":"2023072301053679300_bib63","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/j.cub.2004.09.055","article-title":"SPD-1 is required for the formation of the spindle midzone but is not essential for the completion of cytokinesis in C. elegans embryos","volume":"14","author":"Verbrugghe","year":"2004","journal-title":"Curr. Biol."},{"key":"2023072301053679300_bib64","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1242\/jcs.03447","article-title":"Cortical centralspindlin and G alpha have parallel roles in furrow initiation in early C. elegans embryos","volume":"120","author":"Verbrugghe","year":"2007","journal-title":"J. Cell Sci."},{"key":"2023072301053679300_bib65","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.tcb.2005.06.007","article-title":"Some assembly required: yeast septins provide the instruction manual","volume":"15","author":"Versele","year":"2005","journal-title":"Trends Cell Biol."},{"key":"2023072301053679300_bib66","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.tcb.2009.01.008","article-title":"Concurrent cues for cytokinetic furrow induction in animal cells","volume":"19","author":"von Dassow","year":"2009","journal-title":"Trends Cell Biol."},{"key":"2023072301053679300_bib67","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nature05109","article-title":"Structural insights into yeast septin organization from polarized fluorescence microscopy","volume":"443","author":"Vrabioiu","year":"2006","journal-title":"Nature."},{"key":"2023072301053679300_bib68","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/nrm2407","article-title":"The septin family of GTPases: architecture and dynamics","volume":"9","author":"Weirich","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023072301053679300_bib69","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.cub.2007.06.070","article-title":"Astral signals spatially bias cortical myosin recruitment to break symmetry and promote cytokinesis","volume":"17","author":"Werner","year":"2007","journal-title":"Curr. Biol."},{"key":"2023072301053679300_bib70","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/0022-5193(83)90342-9","article-title":"On the mechanisms of cytokinesis in animal cells","volume":"101","author":"White","year":"1983","journal-title":"J. Theor. Biol."},{"key":"2023072301053679300_bib71","first-page":"163","article-title":"The mechanics and mechanism of cleavage","volume":"10","author":"Wolpert","year":"1960","journal-title":"Int. Rev. Cytol."},{"key":"2023072301053679300_bib72","doi-asserted-by":"publisher","first-page":"44756","DOI":"10.1074\/jbc.M402292200","article-title":"Cell type-specific regulation of RhoA activity during cytokinesis","volume":"279","author":"Yoshizaki","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2023072301053679300_bib73","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1083\/jcb.200501097","article-title":"An ECT2-centralspindlin complex regulates the localization and function of RhoA","volume":"170","author":"Y\u00fcce","year":"2005","journal-title":"J. Cell Biol."},{"key":"2023072301053679300_bib74","doi-asserted-by":"publisher","first-page":"5381","DOI":"10.1242\/jcs.02652","article-title":"Tum\/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster","volume":"118","author":"Zavortink","year":"2005","journal-title":"J. Cell Sci."},{"key":"2023072301053679300_bib75","doi-asserted-by":"publisher","first-page":"R135","DOI":"10.1016\/j.cub.2009.12.017","article-title":"Anillin","volume":"20","author":"Zhang","year":"2010","journal-title":"Curr. Biol."},{"key":"2023072301053679300_bib76","doi-asserted-by":"publisher","first-page":"13158","DOI":"10.1073\/pnas.0504145102","article-title":"MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis","volume":"102","author":"Zhao","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072301053679300_bib77","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1091\/mbc.E07-08-0783","article-title":"Distinct pathways for the early recruitment of myosin II and actin to the cytokinetic furrow","volume":"19","author":"Zhou","year":"2008","journal-title":"Mol. Biol. Cell."},{"key":"2023072301053679300_bib78","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1042\/BJ20050097","article-title":"Recruitment of MKLP1 to the spindle midzone\/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells","volume":"389","author":"Zhu","year":"2005","journal-title":"Biochem. J."}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/193\/1\/155\/1566928\/jcb_201008138.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/193\/1\/155\/1566928\/jcb_201008138.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T21:07:48Z","timestamp":1690060068000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/193\/1\/155\/36438\/The-chromosomal-passenger-complex-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,4]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,4,4]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.201008138","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717968467.793468207","asserted-by":"object"}]},"ISSN":["1540-8140","0021-9525"],"issn-type":[{"value":"1540-8140","type":"electronic"},{"value":"0021-9525","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4,4]]}}}