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Lack of KLC1 did not inhibit phagosome speed, but run length was decreased, and phagosome localization and degradation were impaired. In old mice, lack of KLC1 resulted in RPE pathogenesis that was strikingly comparable to aspects of age-related macular degeneration (AMD), with an excessive accumulation of RPE and sub-RPE deposits, as well as oxidative and inflammatory stress responses. These results elucidate mechanisms of POS phagosome transport in relation to degradation, and demonstrate that defective microtubule motor transport in the RPE leads to phenotypes associated with AMD.<\/jats:p>","DOI":"10.1083\/jcb.201410112","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T02:40:10Z","timestamp":1439260810000},"page":"595-611","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":77,"title":["Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis"],"prefix":"10.1083","volume":"210","author":[{"given":"Mei","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA 90095 1"}]},{"given":"Julian","family":"Esteve-Rudd","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA 90095 1"}]},{"given":"Vanda S.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA 90095 1"},{"name":"Centre of Ophthalmology, Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University Coimbra, 3000-548 Coimbra, Portugal 5"}]},{"given":"Tanja","family":"Diemer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA 90095 1"}]},{"given":"Concepci\u00f3n","family":"Lillo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093 6"}]},{"given":"Agrani","family":"Rump","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA 90095 1"}]},{"given":"David S.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA 90095 1"},{"name":"Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 2"},{"name":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095 3"},{"name":"Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095 4"},{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093 6"},{"name":"Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093 7"}]}],"member":"291","published-online":{"date-parts":[[2015,8,10]]},"reference":[{"key":"2023072308150448600_bib1","doi-asserted-by":"publisher","first-page":"2742","DOI":"10.1091\/mbc.12.9.2742","article-title":"Myosin Va bound to phagosomes binds to F-actin and delays microtubule-dependent motility","volume":"12","author":"Al-Haddad","year":"2001","journal-title":"Mol. 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