{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:21:55Z","timestamp":1776226915356,"version":"3.50.1"},"reference-count":54,"publisher":"Rockefeller University Press","issue":"7","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,9,28]]},"abstract":"<jats:p>Autophagy is a key degradative pathway coordinated by external cues, including starvation, oxidative stress, or pathogen detection. Rare are the molecules known to contribute mechanistically to the regulation of autophagy and expressed specifically in particular environmental contexts or in distinct cell types. Here, we unravel the role of RUN and FYVE domain\u2013containing protein 4 (RUFY4) as a positive molecular regulator of macroautophagy in primary dendritic cells (DCs). We show that exposure to interleukin-4 (IL-4) during DC differentiation enhances autophagy flux through mTORC1 regulation and RUFY4 induction, which in turn actively promote LC3 degradation, Syntaxin 17\u2013positive autophagosome formation, and lysosome tethering. Enhanced autophagy boosts endogenous antigen presentation by MHC II and allows host control of Brucella abortus replication in IL-4\u2013treated DCs and in RUFY4-expressing cells. RUFY4 is therefore the first molecule characterized to date that promotes autophagy and influences endosome dynamics in a subset of immune cells.<\/jats:p>","DOI":"10.1083\/jcb.201501059","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T13:28:20Z","timestamp":1443446900000},"page":"1133-1152","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":56,"title":["RUN and FYVE domain\u2013containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4"],"prefix":"10.1083","volume":"210","author":[{"given":"Seigo","family":"Terawaki","sequence":"first","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Aix Marseille Universit\u00e9 UM2, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1104, Centre National de la Recherche Scientifique UMR7280, 13288 Marseille, France 1"}]},{"given":"Voahirana","family":"Camosseto","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Aix Marseille Universit\u00e9 UM2, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1104, Centre National de la Recherche Scientifique UMR7280, 13288 Marseille, France 1"}]},{"given":"Francesca","family":"Prete","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Aix Marseille Universit\u00e9 UM2, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1104, Centre National de la Recherche Scientifique UMR7280, 13288 Marseille, France 1"}]},{"given":"Till","family":"Wenger","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Aix Marseille Universit\u00e9 UM2, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1104, Centre National de la Recherche Scientifique UMR7280, 13288 Marseille, France 1"}]},{"given":"Alexia","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Aix Marseille Universit\u00e9 UM2, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1104, Centre National de la Recherche Scientifique UMR7280, 13288 Marseille, France 1"}]},{"given":"Christiane","family":"Rondeau","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pathologie et biologie cellulaire, Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec H3C 3J7, Canada 2"}]},{"given":"Alexis","family":"Combes","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Aix Marseille Universit\u00e9 UM2, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1104, Centre National de la Recherche Scientifique UMR7280, 13288 Marseille, France 1"}]},{"given":"Christian","family":"Rodriguez Rodrigues","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Aix Marseille Universit\u00e9 UM2, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1104, Centre National de la Recherche Scientifique UMR7280, 13288 Marseille, France 1"}]},{"given":"Thien-Phong","family":"Vu Manh","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Aix Marseille Universit\u00e9 UM2, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1104, Centre National de la Recherche Scientifique UMR7280, 13288 Marseille, France 1"}]},{"given":"Mathieu","family":"Fallet","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Aix Marseille Universit\u00e9 UM2, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1104, Centre National de la Recherche Scientifique UMR7280, 13288 Marseille, France 1"}]},{"given":"Luc","family":"English","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pathologie et biologie 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