{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:50:54Z","timestamp":1777107054071,"version":"3.51.4"},"reference-count":66,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,12,7]]},"abstract":"<jats:p>Intracellular transport is mediated by molecular motors that bind cargo to be transported along the cytoskeleton. Here, we report, for the first time, that peroxisomes (POs), lipid droplets (LDs), and the endoplasmic reticulum (ER) rely on early endosomes (EEs) for intracellular movement in a fungal model system. We show that POs undergo kinesin-3\u2013 and dynein-dependent transport along microtubules. Surprisingly, kinesin-3 does not colocalize with POs. Instead, the motor moves EEs that drag the POs through the cell. PO motility is abolished when EE motility is blocked in various mutants. Most LD and ER motility also depends on EE motility, whereas mitochondria move independently of EEs. Covisualization studies show that EE-mediated ER motility is not required for PO or LD movement, suggesting that the organelles interact with EEs independently. In the absence of EE motility, POs and LDs cluster at the growing tip, whereas ER is partially retracted to subapical regions. Collectively, our results show that moving EEs interact transiently with other organelles, thereby mediating their directed transport and distribution in the cell.<\/jats:p>","DOI":"10.1083\/jcb.201505086","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T22:38:39Z","timestamp":1448923119000},"page":"945-954","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":129,"title":["Peroxisomes, lipid droplets, and endoplasmic reticulum \u201chitchhike\u201d on motile early endosomes"],"prefix":"10.1083","volume":"211","author":[{"given":"Sofia C.","family":"Guimaraes","sequence":"first","affiliation":[{"name":"Biosciences, University of Exeter, Exeter EX4 4QD, England, UK"}]},{"given":"Martin","family":"Schuster","sequence":"additional","affiliation":[{"name":"Biosciences, University of Exeter, Exeter EX4 4QD, England, UK"}]},{"given":"Ewa","family":"Bielska","sequence":"additional","affiliation":[{"name":"Biosciences, University of Exeter, Exeter EX4 4QD, England, UK"}]},{"given":"Gulay","family":"Dagdas","sequence":"additional","affiliation":[{"name":"Biosciences, University of Exeter, Exeter EX4 4QD, England, UK"}]},{"given":"Sreedhar","family":"Kilaru","sequence":"additional","affiliation":[{"name":"Biosciences, University of Exeter, Exeter EX4 4QD, England, UK"}]},{"given":"Ben R.A.","family":"Meadows","sequence":"additional","affiliation":[{"name":"Biosciences, University of Exeter, Exeter EX4 4QD, England, UK"}]},{"given":"Michael","family":"Schrader","sequence":"additional","affiliation":[{"name":"Biosciences, University of Exeter, Exeter EX4 4QD, England, UK"}]},{"given":"Gero","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Biosciences, University of Exeter, Exeter EX4 4QD, England, UK"}]}],"member":"291","published-online":{"date-parts":[[2015,11,30]]},"reference":[{"key":"2023072308180660600_bib1","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1091\/mbc.E03-09-0675","article-title":"Calcium signaling is involved in dynein-dependent microtubule organization","volume":"15","author":"Adam\u00edkov\u00e1","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"2023072308180660600_bib2","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.ceb.2010.04.008","article-title":"Linking molecular motors to membrane cargo","volume":"22","author":"Akhmanova","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072308180660600_bib3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ceb.2015.04.017","article-title":"Lipid droplet-organelle interactions: emerging roles in lipid metabolism","volume":"35","author":"Barbosa","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072308180660600_bib4","doi-asserted-by":"publisher","first-page":"2740","DOI":"10.1242\/jcs.101212","article-title":"Kinesin-3 and dynein mediate microtubule-dependent co-transport of mRNPs and endosomes","volume":"125","author":"Baumann","year":"2012","journal-title":"J. Cell Sci."},{"key":"2023072308180660600_bib5","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1002\/embr.201338037","article-title":"Endosomal transport of septin mRNA and protein indicates local translation on endosomes and is required for correct septin filamentation","volume":"15","author":"Baumann","year":"2014","journal-title":"EMBO Rep."},{"key":"2023072308180660600_bib6","doi-asserted-by":"publisher","first-page":"4964","DOI":"10.1242\/jcs.03287","article-title":"The RNA-binding protein Rrm4 is essential for polarity in Ustilago maydis and shuttles along microtubules","volume":"119","author":"Becht","year":"2006","journal-title":"J. Cell Sci."},{"key":"2023072308180660600_bib7","doi-asserted-by":"publisher","first-page":"5097","DOI":"10.1038\/ncomms6097","article-title":"Long-distance endosome trafficking drives fungal effector production during plant infection","volume":"5","author":"Bielska","year":"2014","journal-title":"Nat. Commun."},{"key":"2023072308180660600_bib8","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1083\/jcb.201309022","article-title":"Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes","volume":"204","author":"Bielska","year":"2014","journal-title":"J. Cell Biol."},{"key":"2023072308180660600_bib9","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1139\/b95-262","article-title":"Genetic regulation of mating and dimorphism in Ustilago maydis","volume":"73","author":"B\u00f6lker","year":"1995","journal-title":"Can. J. Bot."},{"key":"2023072308180660600_bib10","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1111\/j.1600-0854.2012.01356.x","article-title":"Transient complex interactions of mammalian peroxisomes without exchange of matrix or membrane marker proteins","volume":"13","author":"Bonekamp","year":"2012","journal-title":"Traffic"},{"key":"2023072308180660600_bib11","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1105\/tpc.104.022657","article-title":"The Ustilago maydis a2 mating-type locus genes lga2 and rga2 compromise pathogenicity in the absence of the mitochondrial p32 family protein Mrb1","volume":"16","author":"Bortfeld","year":"2004","journal-title":"Plant Cell"},{"key":"2023072308180660600_bib12","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1046\/j.1365-2958.2001.02699.x","article-title":"Identification of genes in the bW\/bE regulatory cascade in Ustilago maydis","volume":"42","author":"Brachmann","year":"2001","journal-title":"Mol. Microbiol."},{"key":"2023072308180660600_bib13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbamcr.2014.10.005","article-title":"New insights into the peroxisomal protein inventory: Acyl-CoA oxidases and -dehydrogenases are an ancient feature of peroxisomes","volume":"1853","author":"Cam\u00f5es","year":"2015","journal-title":"Biochim. Biophys. Acta."},{"key":"2023072308180660600_bib14","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.cell.2015.02.019","article-title":"Cholesterol transport through lysosome-peroxisome membrane contacts","volume":"161","author":"Chu","year":"2015","journal-title":"Cell"},{"key":"2023072308180660600_bib15","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1083\/jcb.201112101","article-title":"Lis1 is an initiation factor for dynein-driven organelle transport","volume":"197","author":"Egan","year":"2012","journal-title":"J. Cell Biol."},{"key":"2023072308180660600_bib16","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1083\/jcb.127.4.1021","article-title":"Kinesin-mediated organelle translocation revealed by specific cellular manipulations","volume":"127","author":"Feiguin","year":"1994","journal-title":"J. Cell Biol."},{"key":"2023072308180660600_bib17","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1091\/mbc.E12-10-0733","article-title":"Endoplasmic reticulum-endosome contact increases as endosomes traffic and mature","volume":"24","author":"Friedman","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"2023072308180660600_bib18","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.tcb.2014.05.002","article-title":"Integrated regulation of motor-driven organelle transport by scaffolding proteins","volume":"24","author":"Fu","year":"2014","journal-title":"Trends Cell Biol."},{"key":"2023072308180660600_bib19","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1091\/mbc.E05-03-0176","article-title":"Microtubules are dispensable for the initial pathogenic development but required for long-distance hyphal growth in the corn smut fungus Ustilago maydis","volume":"16","author":"Fuchs","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"2023072308180660600_bib20","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1105\/tpc.105.039388","article-title":"Endocytosis is essential for pathogenic development in the corn smut fungus Ustilago maydis","volume":"18","author":"Fuchs","year":"2006","journal-title":"Plant Cell"},{"key":"2023072308180660600_bib21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3389\/fcell.2015.00049","article-title":"The lipid droplet-a well-connected organelle","volume":"3","author":"Gao","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"key":"2023072308180660600_bib22","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/nrm2652","article-title":"New roles for endosomes: from vesicular carriers to multi-purpose platforms","volume":"10","author":"Gould","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023072308180660600_bib23","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.ceb.2015.02.002","article-title":"The life cycle of lipid droplets","volume":"33","author":"Hashemi","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072308180660600_bib24","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1083\/jcb.201307164","article-title":"Early endosome motility spatially organizes polysome distribution","volume":"204","author":"Higuchi","year":"2014","journal-title":"J. Cell Biol."},{"key":"2023072308180660600_bib25","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1083\/jcb.200107028","article-title":"A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae","volume":"155","author":"Hoepfner","year":"2001","journal-title":"J. Cell Biol."},{"key":"2023072308180660600_bib26","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1083\/jcb.114.6.1167","article-title":"PAS3, a Saccharomyces cerevisiae gene encoding a peroxisomal integral membrane protein essential for peroxisome biogenesis","volume":"114","author":"H\u00f6hfeld","year":"1991","journal-title":"J. Cell Biol."},{"key":"2023072308180660600_bib27","first-page":"575","article-title":"Ustilago maydis","volume-title":"Handbook of Genetics.","author":"Holliday","year":"1974"},{"key":"2023072308180660600_bib28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0955-0674(01)00295-2","article-title":"Principles of cargo attachment to cytoplasmic motor proteins","volume":"14","author":"Kamal","year":"2002","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072308180660600_bib29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0962-8924(01)02184-5","article-title":"Motor-cargo interactions: the key to transport specificity","volume":"12","author":"Karcher","year":"2002","journal-title":"Trends Cell Biol."},{"key":"2023072308180660600_bib30","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1002\/(SICI)1097-0061(199907)15:10B&lt;963::AID-YEA399&gt;3.0.CO;2-W","article-title":"Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routines","volume":"15","author":"Knop","year":"1999","journal-title":"Yeast"},{"key":"2023072308180660600_bib31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1534\/genetics.112.143362","article-title":"Lipid droplets and peroxisomes: key players in cellular lipid homeostasis or a matter of fat--store \u2018em up or burn \u2019em down","volume":"193","author":"Kohlwein","year":"2013","journal-title":"Genetics"},{"key":"2023072308180660600_bib32","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1126\/science.1108408","article-title":"Kinesin and dynein move a peroxisome in vivo: a tug-of-war or coordinated movement?","volume":"308","author":"Kural","year":"2005","journal-title":"Science"},{"key":"2023072308180660600_bib33","doi-asserted-by":"publisher","first-page":"e3763","DOI":"10.1371\/journal.pone.0003763","article-title":"BicaudalD actively regulates microtubule motor activity in lipid droplet transport","volume":"3","author":"Larsen","year":"2008","journal-title":"PLoS One"},{"key":"2023072308180660600_bib34","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1093\/emboj\/21.6.1289","article-title":"Late endosome motility depends on lipids via the small GTPase Rab7","volume":"21","author":"Lebrand","year":"2002","journal-title":"EMBO J."},{"key":"2023072308180660600_bib35","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1034\/j.1600-0854.2004.00071.x","article-title":"Phosphoinositide recognition domains","volume":"4","author":"Lemmon","year":"2003","journal-title":"Traffic"},{"key":"2023072308180660600_bib36","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1104\/pp.011018","article-title":"Simultaneous visualization of peroxisomes and cytoskeletal elements reveals actin and not microtubule-based peroxisome motility in plants","volume":"128","author":"Mathur","year":"2002","journal-title":"Plant Physiol."},{"key":"2023072308180660600_bib37","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.ceb.2004.06.005","article-title":"Not just a sink: endosomes in control of signal transduction","volume":"16","author":"Miaczynska","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072308180660600_bib38","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s13238-011-1061-y","article-title":"Interactomic study on interaction between lipid droplets and mitochondria","volume":"2","author":"Pu","year":"2011","journal-title":"Protein Cell"},{"key":"2023072308180660600_bib39","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1242\/jcs.109.4.837","article-title":"Microtubule-based peroxisome movement","volume":"109","author":"Rapp","year":"1996","journal-title":"J. Cell. Sci."},{"key":"2023072308180660600_bib40","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2144\/99261rr02","article-title":"General method for plasmid construction using homologous recombination","volume":"26","author":"Raymond","year":"1999","journal-title":"Biotechniques."},{"key":"2023072308180660600_bib41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-94-007-6889-5_1","article-title":"Peroxisome interactions and cross-talk with other subcellular compartments in animal cells","volume":"69","author":"Schrader","year":"2013","journal-title":"Subcell. Biochem."},{"key":"2023072308180660600_bib42","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fcell.2015.00056","article-title":"The different facets of organelle interplay-an overview of organelle interactions","volume":"3","author":"Schrader","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"key":"2023072308180660600_bib43","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0092-8674(90)90744-Y","article-title":"The b alleles of U. maydis, whose combinations program pathogenic development, code for polypeptides containing a homeodomain-related motif","volume":"60","author":"Schulz","year":"1990","journal-title":"Cell"},{"key":"2023072308180660600_bib44","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/emboj.2010.360","article-title":"Controlled and stochastic retention concentrates dynein at microtubule ends to keep endosomes on track","volume":"30","author":"Schuster","year":"2011","journal-title":"EMBO J."},{"key":"2023072308180660600_bib45","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1091\/mbc.E11-03-0217","article-title":"Kinesin-3 and dynein cooperate in long-range retrograde endosome motility along a nonuniform microtubule array","volume":"22","author":"Schuster","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"2023072308180660600_bib46","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1073\/pnas.1015839108","article-title":"Transient binding of dynein controls bidirectional long-range motility of early endosomes","volume":"108","author":"Schuster","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023072308180660600_bib47","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/emboj.2011.361","article-title":"Myosin-5, kinesin-1 and myosin-17 cooperate in secretion of fungal chitin synthase","volume":"31","author":"Schuster","year":"2012","journal-title":"EMBO J."},{"key":"2023072308180660600_bib48","first-page":"S0167-4889(15)00309-2","article-title":"No peroxisome is an island - Peroxisome contact sites","author":"Shai","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"2023072308180660600_bib49","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1016\/j.cell.2008.10.021","article-title":"Consequences of motor copy number on the intracellular transport of kinesin-1-driven lipid droplets","volume":"135","author":"Shubeita","year":"2008","journal-title":"Cell"},{"key":"2023072308180660600_bib50","first-page":"503","article-title":"Green fluorescent protein (GFP) as a new vital marker in the phytopathogenic fungus Ustilago maydis","volume":"252","author":"Spellig","year":"1996","journal-title":"Mol. Gen. Genet."},{"key":"2023072308180660600_bib51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mib.2014.04.001","article-title":"Endocytosis and early endosome motility in filamentous fungi","volume":"20","author":"Steinberg","year":"2014","journal-title":"Curr. Opin. Microbiol."},{"key":"2023072308180660600_bib52","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.fbr.2011.01.008","article-title":"The dynamic fungal cell","volume":"25","author":"Steinberg","year":"2011","journal-title":"Fungal Biol. Rev."},{"key":"2023072308180660600_bib53","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1242\/jcs.114.3.609","article-title":"Microtubules in the fungal pathogen Ustilago maydis are highly dynamic and determine cell polarity","volume":"114","author":"Steinberg","year":"2001","journal-title":"J. Cell. Sci."},{"key":"2023072308180660600_bib54","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1126\/science.272.5267.1495","article-title":"A subfamily of P-type ATPases with aminophospholipid transporting activity","volume":"272","author":"Tang","year":"1996","journal-title":"Science"},{"key":"2023072308180660600_bib55","doi-asserted-by":"publisher","first-page":"15998","DOI":"10.1074\/jbc.M211289200","article-title":"Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein","volume":"278","author":"Targett-Adams","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2023072308180660600_bib56","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1146\/annurev.biochem.74.082803.133329","article-title":"Biochemistry of mammalian peroxisomes revisited","volume":"75","author":"Wanders","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"2023072308180660600_bib57","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/S0960-9822(98)70321-5","article-title":"Endoplasmic reticulum membrane tubules are distributed by microtubules in living cells using three distinct mechanisms","volume":"8","author":"Waterman-Storer","year":"1998","journal-title":"Curr. Biol."},{"key":"2023072308180660600_bib58","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1093\/emboj\/19.9.1974","article-title":"A putative endosomal t-SNARE links exo- and endocytosis in the phytopathogenic fungus Ustilago maydis","volume":"19","author":"Wedlich-S\u00f6ldner","year":"2000","journal-title":"EMBO J."},{"key":"2023072308180660600_bib59","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1091\/mbc.01-10-0475","article-title":"Dynein supports motility of endoplasmic reticulum in the fungus Ustilago maydis","volume":"13","author":"Wedlich-S\u00f6ldner","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"2023072308180660600_bib60","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.1093\/emboj\/cdf296","article-title":"A balance of KIF1A-like kinesin and dynein organizes early endosomes in the fungus Ustilago maydis","volume":"21","author":"Wedlich-S\u00f6ldner","year":"2002","journal-title":"EMBO J."},{"key":"2023072308180660600_bib61","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1042\/BST0370991","article-title":"Fat on the move: intracellular motion of lipid droplets","volume":"37","author":"Welte","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"2023072308180660600_bib62","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1083\/jcb.136.1.71","article-title":"Visualization of the peroxisomal compartment in living mammalian cells: dynamic behavior and association with microtubules","volume":"136","author":"Wiemer","year":"1997","journal-title":"J. Cell Biol."},{"key":"2023072308180660600_bib63","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/yea.320110107","article-title":"Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S288C","volume":"11","author":"Winston","year":"1995","journal-title":"Yeast"},{"key":"2023072308180660600_bib64","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1242\/jcs.041962","article-title":"Role of kinesin-1 and cytoplasmic dynein in endoplasmic reticulum movement in VERO cells","volume":"122","author":"Wo\u017aniak","year":"2009","journal-title":"J. Cell Sci."},{"key":"2023072308180660600_bib65","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1083\/jcb.201308009","article-title":"HookA is a novel dynein-early endosome linker critical for cargo movement in vivo","volume":"204","author":"Zhang","year":"2014","journal-title":"J. Cell Biol."},{"key":"2023072308180660600_bib66","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1128\/jb.175.10.2853-2858.1993","article-title":"Sterol composition of yeast organelle membranes and subcellular distribution of enzymes involved in sterol metabolism","volume":"175","author":"Zinser","year":"1993","journal-title":"J. Bacteriol."}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/211\/5\/945\/1593225\/jcb_201505086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/211\/5\/945\/1593225\/jcb_201505086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T04:20:22Z","timestamp":1690086022000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/211\/5\/945\/38381\/Peroxisomes-lipid-droplets-and-endoplasmic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,30]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,12,7]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.201505086","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725975729.793512328","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.725975729.793525618","asserted-by":"object"}]},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,30]]}}}