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However, the full nature of the local events governing presynaptic assembly remains unknown. Herein, we investigated the involvement of the ubiquitin\u2013proteasome system (UPS), the major degradative pathway, in the local modulation of presynaptic differentiation. We found that proteasome inhibition has a synaptogenic effect on isolated axons. In addition, formation of a stable cluster of synaptic vesicles onto a postsynaptic partner occurs in parallel to an on-site decrease in proteasome degradation. Accumulation of ubiquitinated proteins at nascent sites is a local trigger for presynaptic clustering. Finally, proteasome-related ubiquitin chains (K11 and K48) function as signals for the assembly of presynaptic terminals. Collectively, we propose a new axon-intrinsic mechanism for presynaptic assembly through local UPS inhibition. Subsequent on-site accumulation of proteins in their polyubiquitinated state triggers formation of presynapses.<\/jats:p>","DOI":"10.1083\/jcb.201509039","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T13:17:57Z","timestamp":1459171077000},"page":"789-801","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates"],"prefix":"10.1083","volume":"212","author":[{"given":"Maria J.","family":"Pinto","sequence":"first","affiliation":[{"name":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal 1"},{"name":"PhD Program in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal 2"}]},{"given":"Pedro L.","family":"Alves","sequence":"additional","affiliation":[{"name":"Instituto de Educa\u00e7\u00e3o e Cidadania, 3770-033 Mamarrosa, Portugal 4"}]},{"given":"Lu\u00eds","family":"Martins","sequence":"additional","affiliation":[{"name":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal 1"}]},{"given":"Joana R.","family":"Pedro","sequence":"additional","affiliation":[{"name":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal 1"}]},{"given":"Hyun R.","family":"Ryu","sequence":"additional","affiliation":[{"name":"Institute of Advanced Machinery and Design, Seoul National University, Seoul 151-744, Korea 5"}]},{"given":"Noo Li","family":"Jeon","sequence":"additional","affiliation":[{"name":"Institute of Advanced Machinery and Design, Seoul National University, Seoul 151-744, Korea 5"},{"name":"Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea 6"}]},{"given":"Anne M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599 7"}]},{"given":"Ramiro D.","family":"Almeida","sequence":"additional","affiliation":[{"name":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal 1"},{"name":"Institute for Interdisciplinary Research, University of Coimbra, 3004-517 Coimbra, Portugal 3"},{"name":"School of Allied Health Technologies, Polytechnic Institute of Porto, 4400-330 Vila Nova de Gaia, Portugal 8"}]}],"member":"291","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"key":"2023072309515820200_bib1","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.chembiol.2011.08.018","article-title":"Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes","volume":"18","author":"Altun","year":"2011","journal-title":"Chem. 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