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However, the molecular identity of the inhibitory signal has remained unknown. To identify molecular components of the aster-based inhibitory signal, we developed a means to monitor the removal of contractile ring proteins from the polar cortex after anaphase onset. Using this assay, we show that polar clearing is an active process that requires activation of Aurora A kinase by TPXL-1. TPXL-1 concentrates on astral microtubules coincident with polar clearing in anaphase, and its ability to recruit Aurora A and activate its kinase activity are essential for clearing. In summary, our data identify Aurora A kinase as an aster-based inhibitory signal that restricts contractile ring components to the cell equator during cytokinesis.<\/jats:p>","DOI":"10.1083\/jcb.201706021","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T08:30:13Z","timestamp":1515400213000},"page":"837-848","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis"],"prefix":"10.1083","volume":"217","author":[{"given":"Sriyash","family":"Mangal","sequence":"first","affiliation":[{"name":"Center for Integrated Protein Science, Department Biology II, Ludwig-Maximilians University Munich, Planegg-Martinsried, Germany 1"}]},{"given":"Jennifer","family":"Sacher","sequence":"additional","affiliation":[{"name":"Center for Integrated Protein Science, Department Biology II, Ludwig-Maximilians University Munich, Planegg-Martinsried, Germany 1"}]},{"given":"Taekyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 2"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4144-8189","authenticated-orcid":true,"given":"Daniel Sampaio","family":"Os\u00f3rio","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal 3"},{"name":"Instituto de Biologia Molecular e Celular, Porto, Portugal 4"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9058-6559","authenticated-orcid":true,"given":"Fumio","family":"Motegi","sequence":"additional","affiliation":[{"name":"Research Link, National University of Singapore, Singapore 5"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2256-7134","authenticated-orcid":true,"given":"Ana Xavier","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal 3"},{"name":"Instituto de Biologia Molecular e Celular, Porto, Portugal 4"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-7514","authenticated-orcid":true,"given":"Karen","family":"Oegema","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 2"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1450-8684","authenticated-orcid":true,"given":"Esther","family":"Zanin","sequence":"additional","affiliation":[{"name":"Center for Integrated Protein Science, Department Biology II, Ludwig-Maximilians University Munich, Planegg-Martinsried, Germany 1"}]}],"member":"291","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"2023072314585179200_bib1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1242\/dev.042754","article-title":"Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos","volume":"137","author":"Afshar","year":"2010","journal-title":"Development."},{"key":"2023072314585179200_bib2","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1083\/jcb.200501131","article-title":"A microtubule-dependent zone of active RhoA during cleavage plane specification","volume":"170","author":"Bement","year":"2005","journal-title":"J. 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