{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T06:09:05Z","timestamp":1776146945834,"version":"3.50.1"},"reference-count":50,"publisher":"Rockefeller University Press","issue":"4","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Research Council"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["681443"],"award-info":[{"award-number":["681443"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"name":"FLAD Life Science 2020","award":["261\/2014"],"award-info":[{"award-number":["261\/2014"]}]},{"name":"Danish Cancer Society Scientific Committee","award":["R146-A9322"],"award-info":[{"award-number":["R146-A9322"]}]},{"name":"Lundbeck Foundation","award":["R215-2015-4081"],"award-info":[{"award-number":["R215-2015-4081"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SFRH\/BD\/79174\/2011"],"award-info":[{"award-number":["SFRH\/BD\/79174\/2011"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["POCI-01-0145-FEDER-016589"],"award-info":[{"award-number":["POCI-01-0145-FEDER-016589"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PPBI-POCI-01-0145-FEDER-022122"],"award-info":[{"award-number":["PPBI-POCI-01-0145-FEDER-022122"]}]},{"DOI":"10.13039\/501100008530","name":"Fundo Europeu de Desenvolvimento Regional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,4,6]]},"abstract":"<jats:p>Incorrect kinetochore\u2013microtubule attachments during mitosis can lead to chromosomal instability, a hallmark of human cancers. Mitotic error correction relies on the kinesin-13 MCAK, a microtubule depolymerase whose activity in vitro is suppressed by \u03b1-tubulin detyrosination\u2014a posttranslational modification enriched on long-lived microtubules. However, whether and how MCAK activity required for mitotic error correction is regulated by \u03b1-tubulin detyrosination remains unknown. Here we found that detyrosinated \u03b1-tubulin accumulates on correct, more stable, kinetochore\u2013microtubule attachments. Experimental manipulation of tubulin tyrosine ligase (TTL) or carboxypeptidase (Vasohibins-SVBP) activities to constitutively increase \u03b1-tubulin detyrosination near kinetochores compromised efficient error correction, without affecting overall kinetochore microtubule stability. Rescue experiments indicate that MCAK centromeric activity was required and sufficient to correct the mitotic errors caused by excessive \u03b1-tubulin detyrosination independently of its global impact on microtubule dynamics. Thus, microtubules are not just passive elements during mitotic error correction, and the extent of \u03b1-tubulin detyrosination allows centromeric MCAK to discriminate correct vs. incorrect kinetochore\u2013microtubule attachments, thereby promoting mitotic fidelity.<\/jats:p>","DOI":"10.1083\/jcb.201910064","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T02:21:50Z","timestamp":1580869310000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["\u03b1-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity"],"prefix":"10.1083","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-3964","authenticated-orcid":true,"given":"Lu\u00edsa T.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Chromosome Instability & Dynamics Group, i3S - Instituto de Investigac\u00e3o e Inovac\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal 1"},{"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal 2"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-7644","authenticated-orcid":true,"given":"Bernardo","family":"Orr","sequence":"additional","affiliation":[{"name":"Chromosome Instability & Dynamics Group, i3S - Instituto de Investigac\u00e3o e Inovac\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal 1"},{"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal 2"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2521-3005","authenticated-orcid":true,"given":"Girish","family":"Rajendraprasad","sequence":"additional","affiliation":[{"name":"Cell Division and Cytoskeleton, Danish Cancer Society Research Center, Copenhagen, Denmark 3"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1053-8715","authenticated-orcid":true,"given":"Ant\u00f3nio J.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Chromosome Instability & Dynamics Group, i3S - Instituto de Investigac\u00e3o e Inovac\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal 1"},{"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal 2"}]},{"given":"Carolina","family":"Lemos","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal 2"},{"name":"UnIGENe, i3S - Instituto de Investigac\u00e3o e Inovac\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal 4"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal 5"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2327-8852","authenticated-orcid":true,"given":"Joana T.","family":"Lima","sequence":"additional","affiliation":[{"name":"Chromosome Instability & Dynamics Group, i3S - Instituto de Investigac\u00e3o e Inovac\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal 1"},{"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal 2"}]},{"given":"Cl\u00e0udia","family":"Guasch Bold\u00fa","sequence":"additional","affiliation":[{"name":"Cell Division and Cytoskeleton, Danish Cancer Society Research Center, Copenhagen, Denmark 3"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6802-3696","authenticated-orcid":true,"given":"Jorge G.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Chromosome Instability & Dynamics Group, i3S - Instituto de Investigac\u00e3o e Inovac\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal 1"},{"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal 2"},{"name":"Cell Division Group, Experimental Biology Unit, Department of Biomedicine, Faculdade de Medicina, Universidade do Porto, Porto, Portugal 6"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7587-3867","authenticated-orcid":true,"given":"Marin","family":"Barisic","sequence":"additional","affiliation":[{"name":"Cell Division and Cytoskeleton, Danish Cancer Society Research Center, Copenhagen, Denmark 3"},{"name":"Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark 7"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-9997","authenticated-orcid":true,"given":"Helder","family":"Maiato","sequence":"additional","affiliation":[{"name":"Chromosome Instability & Dynamics Group, i3S - Instituto de Investigac\u00e3o e Inovac\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal 1"},{"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal 2"},{"name":"Cell Division Group, Experimental Biology Unit, Department of Biomedicine, Faculdade de Medicina, Universidade do Porto, Porto, Portugal 6"}]}],"member":"291","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"2023072811444036200_bib1","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1126\/science.aao4165","article-title":"Vasohibins\/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation","volume":"358","author":"Aillaud","year":"2017","journal-title":"Science."},{"key":"2023072811444036200_bib2","first-page":"668","article-title":"Spindle asymmetry drives non-Mendelian chromosome segregation","volume-title":"Science","author":"Akera","year":"2017"},{"key":"2023072811444036200_bib3","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1534-5807(04)00025-5","article-title":"Aurora B regulates MCAK at the mitotic centromere","volume":"6","author":"Andrews","year":"2004","journal-title":"Dev. Cell."},{"key":"2023072811444036200_bib4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1432-1033.1975.tb02435.x","article-title":"Incorporation of L-tyrosine, L-phenylalanine and L-3,4-dihydroxyphenylalanine as single units into rat brain tubulin","volume":"59","author":"Arce","year":"1975","journal-title":"Eur. J. Biochem."},{"key":"2023072811444036200_bib5","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1016\/j.cell.2018.08.027","article-title":"The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment","volume":"174","author":"Bakhoum","year":"2018","journal-title":"Cell."},{"key":"2023072811444036200_bib6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/ncb1809","article-title":"Genome stability is ensured by temporal control of kinetochore-microtubule dynamics","volume":"11","author":"Bakhoum","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"2023072811444036200_bib7","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1126\/science.aaa5175","article-title":"Mitosis. Microtubule detyrosination guides chromosomes during mitosis","volume":"348","author":"Barisic","year":"2015","journal-title":"Science."},{"key":"2023072811444036200_bib8","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/s41591-018-0046-2","article-title":"Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure","volume":"24","author":"Chen","year":"2018","journal-title":"Nat. Med."},{"key":"2023072811444036200_bib9","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.1242\/jcs.00716","article-title":"Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms","volume":"116","author":"Cimini","year":"2003","journal-title":"J. Cell Sci."},{"key":"2023072811444036200_bib10","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/j.cub.2006.07.022","article-title":"Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors","volume":"16","author":"Cimini","year":"2006","journal-title":"Curr. Biol."},{"key":"2023072811444036200_bib11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nature10802","article-title":"DNA breaks and chromosome pulverization from errors in mitosis","volume":"482","author":"Crasta","year":"2012","journal-title":"Nature."},{"key":"2023072811444036200_bib12","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1083\/jcb.201108147","article-title":"MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment","volume":"197","author":"Domnitz","year":"2012","journal-title":"J. Cell Biol."},{"key":"2023072811444036200_bib13","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.120140","article-title":"Exotic mitotic mechanisms","volume":"2","author":"Drechsler","year":"2012","journal-title":"Open Biol."},{"key":"2023072811444036200_bib14","doi-asserted-by":"publisher","first-page":"7853","DOI":"10.1073\/pnas.0409626102","article-title":"A vital role of tubulin-tyrosine-ligase for neuronal organization","volume":"102","author":"Erck","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072811444036200_bib15","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1083\/jcb.120.3.725","article-title":"Characterization of the tubulin-tyrosine ligase","volume":"120","author":"Ersfeld","year":"1993","journal-title":"J. Cell Biol."},{"key":"2023072811444036200_bib16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/bs.mcb.2018.03.040","article-title":"Dissecting the role of the tubulin code in mitosis","volume":"144","author":"Ferreira","year":"2018","journal-title":"Methods Cell Biol."},{"key":"2023072811444036200_bib17","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1083\/jcb.200404012","article-title":"The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK","volume":"166","author":"Ganem","year":"2004","journal-title":"J. Cell Biol."},{"key":"2023072811444036200_bib18","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1016\/j.cub.2005.08.065","article-title":"Efficient mitosis in human cells lacking poleward microtubule flux","volume":"15","author":"Ganem","year":"2005","journal-title":"Curr. Biol."},{"key":"2023072811444036200_bib19","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1158\/1535-7163.MCT-10-1109","article-title":"Overexpression of mitotic centromere-associated Kinesin stimulates microtubule detachment and confers resistance to paclitaxel","volume":"10","author":"Ganguly","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"2023072811444036200_bib20","doi-asserted-by":"publisher","first-page":"36378","DOI":"10.1074\/jbc.M111.296483","article-title":"Mitotic centromere-associated kinesin (MCAK) mediates paclitaxel resistance","volume":"286","author":"Ganguly","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2023072811444036200_bib21","doi-asserted-by":"publisher","first-page":"4159","DOI":"10.1073\/pnas.0912143106","article-title":"Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle","volume":"107","author":"Guerrero","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072811444036200_bib22","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1083\/jcb.200701122","article-title":"Tripin\/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments","volume":"177","author":"Huang","year":"2007","journal-title":"J. Cell Biol."},{"key":"2023072811444036200_bib23","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature12507","article-title":"Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation","volume":"502","author":"Kabeche","year":"2013","journal-title":"Nature."},{"key":"2023072811444036200_bib24","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1083\/jcb.150.5.975","article-title":"Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5","volume":"150","author":"Kapoor","year":"2000","journal-title":"J. Cell Biol."},{"key":"2023072811444036200_bib25","doi-asserted-by":"publisher","first-page":"8526","DOI":"10.1038\/ncomms9526","article-title":"Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle","volume":"6","author":"Kerr","year":"2015","journal-title":"Nat. Commun."},{"key":"2023072811444036200_bib26","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1091\/mbc.e03-08-0581","article-title":"Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments","volume":"15","author":"Kline-Smith","year":"2004","journal-title":"Mol. Biol. Cell."},{"key":"2023072811444036200_bib27","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1016\/j.cub.2006.07.057","article-title":"Aurora B is enriched at merotelic attachment sites, where it regulates MCAK","volume":"16","author":"Knowlton","year":"2006","journal-title":"Curr. Biol."},{"key":"2023072811444036200_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1242\/jcs.111.2.171","article-title":"Suppression of tubulin tyrosine ligase during tumor growth","volume":"111","author":"Lafanech\u00e8re","year":"1998","journal-title":"J. Cell Sci."},{"key":"2023072811444036200_bib29","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cub.2004.01.055","article-title":"Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity","volume":"14","author":"Lan","year":"2004","journal-title":"Curr. Biol."},{"key":"2023072811444036200_bib30","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/s41422-019-0187-y","article-title":"Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis","volume":"29","author":"Liao","year":"2019","journal-title":"Cell Res."},{"key":"2023072811444036200_bib31","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1126\/science.1167000","article-title":"Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates","volume":"323","author":"Liu","year":"2009","journal-title":"Science."},{"key":"2023072811444036200_bib32","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1091\/mbc.e07-02-0110","article-title":"The kinesin-13 proteins Kif2a, Kif2b, and Kif2c\/MCAK have distinct roles during mitosis in human cells","volume":"18","author":"Manning","year":"2007","journal-title":"Mol. Biol. Cell."},{"key":"2023072811444036200_bib33","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.tcb.2018.08.003","article-title":"The Tubulin Detyrosination Cycle: Function and Enzymes","volume":"29","author":"Nieuwenhuis","year":"2019","journal-title":"Trends Cell Biol."},{"key":"2023072811444036200_bib34","first-page":"1453","article-title":"Vasohibins encode tubulin detyrosinating activity","volume-title":"Science","author":"Nieuwenhuis","year":"2017"},{"key":"2023072811444036200_bib35","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/j.celrep.2016.10.030","article-title":"Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells","volume":"17","author":"Orr","year":"2016","journal-title":"Cell Reports."},{"key":"2023072811444036200_bib36","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.1093\/hmg\/ddz186","article-title":"Defective tubulin detyrosination causes structural brain abnormalities with cognitive deficiency in humans and mice","volume":"28","author":"Pagnamenta","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"2023072811444036200_bib37","doi-asserted-by":"publisher","first-page":"8092","DOI":"10.1364\/OE.27.008092","article-title":"Coherent-hybrid STED: high contrast sub-diffraction imaging using a bi-vortex depletion beam","volume":"27","author":"Pereira","year":"2019","journal-title":"Opt. Express."},{"key":"2023072811444036200_bib38","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1083\/jcb.200902142","article-title":"Motor-dependent microtubule disassembly driven by tubulin tyrosination","volume":"185","author":"Peris","year":"2009","journal-title":"J. Cell Biol."},{"key":"2023072811444036200_bib39","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1083\/jcb.201211017","article-title":"Structural basis of tubulin tyrosination by tubulin tyrosine ligase","volume":"200","author":"Prota","year":"2013","journal-title":"J. Cell Biol."},{"key":"2023072811444036200_bib40","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/S0006-291X(75)80497-9","article-title":"An enzyme tyrosylating alpha-tubulin and its role in microtubule assembly","volume":"65","author":"Raybin","year":"1975","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023072811444036200_bib41","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1091\/mbc.e08-09-0985","article-title":"MCAK and paclitaxel have differential effects on spindle microtubule organization and dynamics","volume":"20","author":"Rizk","year":"2009","journal-title":"Mol. Biol. Cell."},{"key":"2023072811444036200_bib42","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf0659","article-title":"Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes","volume":"352","author":"Robison","year":"2016","journal-title":"Science."},{"key":"2023072811444036200_bib43","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1093\/bioinformatics\/btv761","article-title":"Vasohibins: new transglutaminase-like cysteine proteases possessing a non-canonical Cys-His-Ser catalytic triad","volume":"32","author":"Sanchez-Pulido","year":"2016","journal-title":"Bioinformatics."},{"key":"2023072811444036200_bib44","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1091\/mbc.e11-02-0095","article-title":"Timing of centrosome separation is important for accurate chromosome segregation","volume":"23","author":"Silkworth","year":"2012","journal-title":"Mol. Biol. Cell."},{"key":"2023072811444036200_bib45","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/ncb2920","article-title":"Regulation of microtubule motors by tubulin isotypes and post-translational modifications","volume":"16","author":"Sirajuddin","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"2023072811444036200_bib46","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1038\/nsmb.2148","article-title":"Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin","volume":"18","author":"Szyk","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2023072811444036200_bib47","first-page":"4159","article-title":"Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination","volume-title":"Cell Rep.","author":"van der Laan","year":"2019"},{"key":"2023072811444036200_bib48","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1083\/jcb.111.1.113","article-title":"Detyrosination of alpha tubulin does not stabilize microtubules in vivo","volume":"111","author":"Webster","year":"1990","journal-title":"J. Cell Biol."},{"key":"2023072811444036200_bib49","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1083\/jcb.200707120","article-title":"MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover","volume":"179","author":"Wordeman","year":"2007","journal-title":"J. Cell Biol."},{"key":"2023072811444036200_bib50","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1083\/jcb.131.3.721","article-title":"Kinetochore microtubule dynamics and the metaphase-anaphase transition","volume":"131","author":"Zhai","year":"1995","journal-title":"J. Cell Biol."}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.201910064\/1831508\/jcb_201910064.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.201910064\/1831508\/jcb_201910064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T07:53:05Z","timestamp":1690530785000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/219\/4\/e201910064\/133849\/Tubulin-detyrosination-impairs-mitotic-error"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,28]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4,6]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.201910064","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/801977","asserted-by":"object"}]},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,28]]},"article-number":"e201910064"}}