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To do so, cells undergo a series of biochemical reactions regulated by cyclin B1-CDK1 that trigger cytoskeletal reorganization and ensure the coordination of cytoplasmic and nuclear events. Along with the biochemical events that control mitotic entry, mechanical forces have recently emerged as important players in cell-cycle regulation. However, the exact link between mechanical forces and the biochemical pathways that control mitotic progression remains unknown. Here, we identify a tension-dependent signal on the nucleus that sets the time for nuclear envelope permeabilization (NEP) and mitotic entry. This signal relies on actomyosin contractility, which unfolds the nucleus during the G2-M transition, activating the stretch-sensitive cPLA2 on the nuclear envelope and regulating the nuclear translocation of cyclin B1. Our data demonstrate how nuclear tension during the G2-M transition contributes to timely and efficient mitotic spindle assembly and prevents chromosomal instability.<\/jats:p>","DOI":"10.1083\/jcb.202205051","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T02:22:01Z","timestamp":1663208521000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation"],"prefix":"10.1083","volume":"221","author":[{"given":"Margarida","family":"Dantas","sequence":"first","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, Porto, Portugal 1"},{"name":"BiotechHealth PhD program, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS), Porto, Portugal 2"}]},{"given":"Andreia","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, Porto, Portugal 1"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4164-5713","authenticated-orcid":true,"given":"Paulo","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, Porto, Portugal 1"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-9997","authenticated-orcid":true,"given":"Helder","family":"Maiato","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, Porto, Portugal 1"},{"name":"Departamento de Biomedicina, Faculdade de Medicina do Porto, Porto, Portugal 3"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal 4"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6802-3696","authenticated-orcid":true,"given":"Jorge G.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, Porto, Portugal 1"},{"name":"Departamento de Biomedicina, Faculdade de Medicina do Porto, Porto, Portugal 3"},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal 4"}]}],"member":"291","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"2022101213204259000_bib1","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1101\/gad.2016411","article-title":"The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II","volume":"25","author":"Abe","year":"2011","journal-title":"Genes Dev."},{"key":"2022101213204259000_bib2","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.molcel.2014.01.031","article-title":"Assessing kinetics from fixed cells reveals activation of the mitotic entry network at the S\/G2 transition","volume":"53","author":"Akopyan","year":"2014","journal-title":"Mol. 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