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However, antitumor treatment was accompanied by fatal autoimmune disease, i.e., autoimmune diabetes in transgenic mice expressing the tumor antigen also in pancreatic \u03b2 islet cells or by severe arteritis, myocarditis, and eventually dilated cardiomyopathy when arterial smooth muscle cells and cardiomyocytes expressed the transgenic tumor antigen. These results reveal the delicate balance between tumor immunity and autoimmunity and therefore point out important limitations for the use of not strictly tumor-specific antigens in antitumor vaccination with DCs.<\/jats:p>","DOI":"10.1084\/jem.191.5.795","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"795-804","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":193,"title":["Immunotherapy with Dendritic Cells Directed against Tumor Antigens Shared with Normal Host Cells Results in Severe Autoimmune Disease"],"prefix":"10.1084","volume":"191","author":[{"given":"Burkhard","family":"Ludewig","sequence":"first","affiliation":[{"name":"aInstitute of Experimental Immunology, CH-8091 Z\u00fcrich, Switzerland"}]},{"given":"Adrian F.","family":"Ochsenbein","sequence":"additional","affiliation":[{"name":"aInstitute of Experimental Immunology, CH-8091 Z\u00fcrich, Switzerland"}]},{"given":"Bernhard","family":"Odermatt","sequence":"additional","affiliation":[{"name":"aInstitute of Experimental Immunology, CH-8091 Z\u00fcrich, Switzerland"}]},{"given":"Denise","family":"Paulin","sequence":"additional","affiliation":[{"name":"bUniversit\u00e9 Paris 7, 75005 Paris, France"}]},{"given":"Hans","family":"Hengartner","sequence":"additional","affiliation":[{"name":"aInstitute of Experimental Immunology, CH-8091 Z\u00fcrich, Switzerland"}]},{"given":"Rolf M.","family":"Zinkernagel","sequence":"additional","affiliation":[{"name":"aInstitute of Experimental Immunology, CH-8091 Z\u00fcrich, Switzerland"}]}],"member":"291","published-online":{"date-parts":[[2000,2,28]]},"reference":[{"key":"2023072509075072000_R1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.180.1.1","article-title":"Cancer antigensimmune recognition of self and altered self","volume":"180","author":"Houghton","year":"1994","journal-title":"J. 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