{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:04:13Z","timestamp":1774562653274,"version":"3.50.1"},"reference-count":19,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,8,7]]},"abstract":"<jats:p>Leukotriene B4 (LTB4) is a potent chemoattractant active on multiple leukocytes, including neutrophils, macrophages, and eosinophils, and is implicated in the pathogenesis of a variety of inflammatory processes. A seven transmembrane\u2013spanning, G protein\u2013coupled receptor, called BLTR (LTB4 receptor), has recently been identified as an LTB4 receptor. To determine if BLTR is the sole receptor mediating LTB4-induced leukocyte activation and to determine the role of LTB4 and BLTR in regulating leukocyte function in inflammation in vivo, we generated a BLTR-deficient mouse by targeted gene disruption. This mouse reveals that BLTR alone is responsible for LTB4-mediated leukocyte calcium flux, chemotaxis, and firm adhesion to endothelium in vivo. Furthermore, despite the apparent functional redundancy with other chemoattractant\u2013receptor pairs in vitro, LTB4 and BLTR play an important role in the recruitment and\/or retention of leukocytes, particularly eosinophils, to the inflamed peritoneum in vivo. These studies demonstrate that BLTR is the key receptor that mediates LTB4-induced leukocyte activation and establishes a model to decipher the functional roles of BLTR and LTB4 in vivo.<\/jats:p>","DOI":"10.1084\/jem.192.3.439","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"439-446","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":147,"title":["Bltr Mediates Leukotriene B4\u2013Induced Chemotaxis and Adhesion and Plays a Dominant Role in Eosinophil Accumulation in a Murine Model of Peritonitis"],"prefix":"10.1084","volume":"192","author":[{"given":"Andrew M.","family":"Tager","sequence":"first","affiliation":[{"name":"aCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer H.","family":"Dufour","sequence":"additional","affiliation":[{"name":"aCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katayoon","family":"Goodarzi","sequence":"additional","affiliation":[{"name":"bCenter for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D.","family":"Bercury","sequence":"additional","affiliation":[{"name":"aCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich H.","family":"von Andrian","sequence":"additional","affiliation":[{"name":"bCenter for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Luster","sequence":"additional","affiliation":[{"name":"aCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2000,8,8]]},"reference":[{"key":"2023072509290851500_R1","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1126\/science.2820055","article-title":"Leukotrienes and lipoxinsstructures, biosynthesis, and biological effects","volume":"237","author":"Samuelsson","year":"1987","journal-title":"Science."},{"key":"2023072509290851500_R2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1056\/NEJM199009063231006","article-title":"Leukotrienes and other products of the 5-lipoxygenase pathway. 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