{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T06:10:54Z","timestamp":1775628654958,"version":"3.50.1"},"reference-count":29,"publisher":"Rockefeller University Press","issue":"8","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,4,15]]},"abstract":"<jats:p>Proteins of the nuclear factor of activated T cells (NFAT) family of transcription factors are critical for lymphocyte activation in the immune system. In particular, NFATs are important regulators of inducible IL-4 gene expression. Interferon regulatory factor 4 (IRF4) is an immune system\u2013restricted interferon regulatory factor that is required for lymphocyte activation, but its molecular functions in the T lineage remain to be elucidated. We demonstrate that IRF4 potently synergizes with NFATc2 to specifically enhance NFATc2-driven transcriptional activation of the IL-4 promoter. This function is dependent on the physical interaction of IRF4 with NFATc2. IRF4 synergizes with NFATc2 and the IL-4\u2013inducing transcription factor, c-maf, to augment IL-4 promoter activity as well as to elicit significant levels of endogenous IL-4 production. Furthermore, nai\u0308ve T helper cells from mice lacking IRF4 are compromised severely for the production of IL-4 and other Th2 cytokines. The identification of IRF4 as a partner for NFATc2 in IL-4 gene regulation provides an important molecular function for IRF4 in T helper cell differentiation.<\/jats:p>","DOI":"10.1084\/jem.20011128","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:54Z","timestamp":1027702134000},"page":"1003-1012","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":278,"title":["Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression"],"prefix":"10.1084","volume":"195","author":[{"given":"Jyothi","family":"Rengarajan","sequence":"first","affiliation":[{"name":"1Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115"}]},{"given":"Kerri A.","family":"Mowen","sequence":"additional","affiliation":[{"name":"1Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115"}]},{"given":"Kathryn D.","family":"McBride","sequence":"additional","affiliation":[{"name":"1Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115"}]},{"given":"Erica D.","family":"Smith","sequence":"additional","affiliation":[{"name":"3Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637"}]},{"given":"Harinder","family":"Singh","sequence":"additional","affiliation":[{"name":"3Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637"}]},{"given":"Laurie H.","family":"Glimcher","sequence":"additional","affiliation":[{"name":"1Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115"},{"name":"2Department of Medicine, Harvard Medical School, Boston, MA 02115"}]}],"member":"291","published-online":{"date-parts":[[2002,4,8]]},"reference":[{"key":"2023072511315951900_BIB1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev.immunol.15.1.707","volume":"15","year":"1997","journal-title":"Annu. 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