{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:52:50Z","timestamp":1770288770164,"version":"3.49.0"},"reference-count":39,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,1,21]]},"abstract":"<jats:p>Natural killer (NK) cells and interferon (IFN)-\u03b3 have been implicated in immune surveillance against tumor development. Here we show that tumor necrosis factor\u2013related apoptosis-inducing ligand (TRAIL) plays a critical role in the NK cell\u2013mediated and IFN-\u03b3\u2013dependent tumor surveillance. Administration of neutralizing monoclonal antibody against TRAIL promoted tumor development in mice subcutaneously inoculated with a chemical carcinogen methylcholanthrene (MCA). This protective effect of TRAIL was at least partly mediated by NK cells and totally dependent on IFN-\u03b3. In the absence of TRAIL, NK cells, or IFN-\u03b3, TRAIL-sensitive sarcomas preferentially emerged in MCA-inoculated mice. Moreover, development of spontaneous tumors in p53+\/\u2212 mice was also promoted by neutralization of TRAIL. These results indicated a substantial role of TRAIL as an effector molecule that eliminates developing tumors.<\/jats:p>","DOI":"10.1084\/jem.20011171","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"161-169","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":339,"title":["Critical Role for Tumor Necrosis Factor\u2013related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development"],"prefix":"10.1084","volume":"195","author":[{"given":"Kazuyoshi","family":"Takeda","sequence":"first","affiliation":[{"name":"1Department of Immunology, Juntendo University, School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan"}]},{"given":"Mark J.","family":"Smyth","sequence":"additional","affiliation":[{"name":"2Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia"}]},{"given":"Erika","family":"Cretney","sequence":"additional","affiliation":[{"name":"2Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia"}]},{"given":"Yoshihiro","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"3Department of Pathogenic Biochemistry, Research Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan"}]},{"given":"Nobuhiko","family":"Kayagaki","sequence":"additional","affiliation":[{"name":"1Department of Immunology, Juntendo University, School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan"}]},{"given":"Hideo","family":"Yagita","sequence":"additional","affiliation":[{"name":"1Department of Immunology, Juntendo University, School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan"}]},{"given":"Ko","family":"Okumura","sequence":"additional","affiliation":[{"name":"1Department of Immunology, Juntendo University, School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan"}]}],"member":"291","published-online":{"date-parts":[[2002,1,14]]},"reference":[{"key":"2023072511264624500_BIB1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/86297","volume":"2","year":"2001","journal-title":"Nat. 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