{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:20:58Z","timestamp":1778570458896,"version":"3.51.4"},"reference-count":29,"publisher":"Rockefeller University Press","issue":"8","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,4,15]]},"abstract":"<jats:p>Adoptive transfer of cross-reactive HSP60-specific CD8+ T cells into immunodeficient mice causes autoimmune intestinal pathology restricted to the small intestine. We wondered whether local immunopathology induced by CD8+ T cells can be explained by tissue-specific differences in proteasome-mediated processing of major histocompatibility complex class I T cell epitopes. Our experiments demonstrate that 20S proteasomes of different organs display a characteristic composition of \u03b1 and \u03b2 chain subunits and produce distinct peptide fragments with respect to both quality and quantity. Digests of HSP60 polypeptides by 20S proteasomes show most efficient generation of the pathology related CD8+ T cell epitope in the small intestine. Further, we demonstrate that the organ-specific potential to produce defined T cell epitopes reflects quantities that are relevant for cytotoxic T lymphocyte recognition. We propose tissue-specific antigen processing by 20S proteasomes as a potential mechanism to control organ-specific immune responses.<\/jats:p>","DOI":"10.1084\/jem.20011199","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:54Z","timestamp":1027702134000},"page":"983-990","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Link between Organ-specific Antigen Processing by 20S Proteasomes and CD8<b>+<\/b> T Cell\u2013mediated Autoimmunity"],"prefix":"10.1084","volume":"195","author":[{"given":"Ulrike","family":"Kuckelkorn","sequence":"first","affiliation":[{"name":"1Institute of Biochemistry, Charite, Humboldt University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Ruppert","sequence":"additional","affiliation":[{"name":"1Institute of Biochemistry, Charite, Humboldt University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Strehl","sequence":"additional","affiliation":[{"name":"1Institute of Biochemistry, Charite, Humboldt University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Jungblut","sequence":"additional","affiliation":[{"name":"2Max-Planck Institute for Infection Biology, D-10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Zimny-Arndt","sequence":"additional","affiliation":[{"name":"2Max-Planck Institute for Infection Biology, D-10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Lamer","sequence":"additional","affiliation":[{"name":"2Max-Planck Institute for Infection Biology, D-10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Immo","family":"Prinz","sequence":"additional","affiliation":[{"name":"2Max-Planck Institute for Infection Biology, D-10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilse","family":"Drung","sequence":"additional","affiliation":[{"name":"1Institute of Biochemistry, Charite, Humboldt University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter-M.","family":"Kloetzel","sequence":"additional","affiliation":[{"name":"1Institute of Biochemistry, Charite, Humboldt University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan H.E.","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"2Max-Planck Institute for Infection Biology, D-10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Steinhoff","sequence":"additional","affiliation":[{"name":"2Max-Planck Institute for Infection Biology, D-10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2002,4,8]]},"reference":[{"key":"2023072511323900400_BIB1","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1126\/science.286.5445.1732","volume":"286","year":"1999","journal-title":"Science."},{"key":"2023072511323900400_BIB2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1074-7613(00)80110-7","volume":"11","year":"1999","journal-title":"Immunity."},{"key":"2023072511323900400_BIB3","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/eji.1830250222","volume":"25","year":"1995","journal-title":"Eur. 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