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The repression of IFN-\u03b3 production is specific in that the expression of other Th1 and Th2 cytokines is unaffected. IL-21 decreases the IL-12 responsiveness of developing Th cells by specifically reducing both signal transducer and activator of transcription 4 protein and mRNA expression. These results suggest that Th2 cell-derived IL-21 regulates the development of IFN-\u03b3\u2013producing Th1 cells which could serve to amplify a Th2 response.<\/jats:p>","DOI":"10.1084\/jem.20020620","type":"journal-article","created":{"date-parts":[[2002,10,8]],"date-time":"2002-10-08T22:39:25Z","timestamp":1034116765000},"page":"969-977","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":201,"title":["Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon \u03b3\u2013producing Th1 Cells"],"prefix":"10.1084","volume":"196","author":[{"given":"Andrea L.","family":"Wurster","sequence":"first","affiliation":[{"name":"1Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115"}]},{"given":"Vikki L.","family":"Rodgers","sequence":"additional","affiliation":[{"name":"1Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115"}]},{"given":"Abhay R.","family":"Satoskar","sequence":"additional","affiliation":[{"name":"2Department of Microbiology, Ohio State University, Columbus, OH 43210"}]},{"given":"Matthew J.","family":"Whitters","sequence":"additional","affiliation":[{"name":"3Wyeth Research, Cambridge, MA 02140"}]},{"given":"Deborah A.","family":"Young","sequence":"additional","affiliation":[{"name":"3Wyeth Research, Cambridge, MA 02140"}]},{"given":"Mary","family":"Collins","sequence":"additional","affiliation":[{"name":"3Wyeth Research, Cambridge, MA 02140"}]},{"given":"Michael J.","family":"Grusby","sequence":"additional","affiliation":[{"name":"1Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115"}]}],"member":"291","published-online":{"date-parts":[[2002,9,30]]},"reference":[{"key":"2023072511472337200_BIB1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/383787a0","volume":"383","year":"1996","journal-title":"Nature."},{"key":"2023072511472337200_BIB2","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1101\/gad.14.14.1693","volume":"14","year":"2000","journal-title":"Genes Dev."},{"key":"2023072511472337200_BIB3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1074-7613(00)80533-6","volume":"8","year":"1998","journal-title":"Immunity."},{"key":"2023072511472337200_BIB4","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.4049\/jimmunol.148.7.2142","volume":"148","year":"1992","journal-title":"J. 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