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At that time, peptides are generated in a proteasome-dependent fashion and used to form peptide\u2013MHC I complexes that appear at the plasma membrane. Unlike MHC II, these events do not involve a marked redistribution of preexisting MHC I molecules from intracellular compartments to the DC surface. Moreover, out of nine stimuli well known to induce the phenotypic maturation of DCs and to promote MHC II presentation, only two (CD40 ligation, disruption of cell\u2013cell contacts) activated cross presentation on MHC I. In contrast, formation of peptide\u2013MHC I complexes from endogenous cytosolic antigens occurs even in unstimulated, immature DCs. Thus, the MHC I and MHC II pathways of antigen presentation are differentially regulated during DC maturation.<\/jats:p>","DOI":"10.1084\/jem.20021542","type":"journal-article","created":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:25:43Z","timestamp":1057019143000},"page":"111-122","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":196,"title":["Presentation of Exogenous Antigens on Major Histocompatibility Complex (MHC) Class I and MHC Class II Molecules Is Differentially Regulated during Dendritic Cell Maturation"],"prefix":"10.1084","volume":"198","author":[{"given":"Le\u0301lia","family":"Delamarre","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520"}]},{"given":"Hilda","family":"Holcombe","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520"}]},{"given":"Ira","family":"Mellman","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520"}]}],"member":"291","published-online":{"date-parts":[[2003,6,30]]},"reference":[{"key":"2023072512150810200_BIB1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(02)80012-8","volume":"80","year":"2002","journal-title":"Adv. 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