{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T14:03:45Z","timestamp":1776002625829,"version":"3.50.1"},"reference-count":61,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,1,5]]},"abstract":"<jats:p>The activator protein 1 (AP-1) transcription factor is a key participant in the control of T cell proliferation, cytokine production, and effector function. In the immune system, AP-1 activity is highest in T cells, suggesting that a subset of T cell\u2013specific coactivator proteins exist to selectively potentiate AP-1 function. Here, we describe that the expression of Schnurri-3, also known as \u03ba recognition component (KRC), is induced upon T cell receptor signaling in T cells and functions to regulate the expression of the interleukin 2 (IL-2) gene. Overexpression of KRC in transformed and primary T cells leads to increased IL-2 production, whereas dominant-negative KRC, or loss of KRC protein in KRC-null mice, results in diminished IL-2 production. KRC physically associates with the c-Jun transcription factor and serves as a coactivator to augment AP-1\u2013dependent IL-2 gene transcription.<\/jats:p>","DOI":"10.1084\/jem.20030421","type":"journal-article","created":{"date-parts":[[2004,1,5]],"date-time":"2004-01-05T20:08:10Z","timestamp":1073333290000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["<i>Schnurri-3<\/i> (KRC) Interacts with c-Jun to Regulate the IL-2 Gene in T Cells"],"prefix":"10.1084","volume":"199","author":[{"given":"Mohamed","family":"Oukka","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115"}]},{"given":"Marc N.","family":"Wein","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115"}]},{"given":"Laurie H.","family":"Glimcher","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115"}]}],"member":"291","published-online":{"date-parts":[[2004,1,5]]},"reference":[{"key":"2023072512154592300_BIB1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/nar\/22.3.383","volume":"22","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"2023072512154592300_BIB2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1006\/geno.1996.0380","volume":"35","year":"1996","journal-title":"Genomics."},{"key":"2023072512154592300_BIB3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2172-3-10","volume":"3","year":"2002","journal-title":"BMC Immunol."},{"key":"2023072512154592300_BIB4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/gene.10084","volume":"33","year":"2002","journal-title":"Genesis."},{"key":"2023072512154592300_BIB5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s002510050397","volume":"48","year":"1998","journal-title":"Immunogenetics."},{"key":"2023072512154592300_BIB6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3727\/000000002783992479","volume":"10","year":"2002","journal-title":"Gene Expr."},{"key":"2023072512154592300_BIB7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/geno.2000.6425","volume":"71","year":"2001","journal-title":"Genomics."},{"key":"2023072512154592300_BIB8","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/nar\/27.2.643","volume":"27","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"2023072512154592300_BIB9","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s002510100360","volume":"53","year":"2001","journal-title":"Immunogenetics."},{"key":"2023072512154592300_BIB10","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1093\/nar\/29.16.3335","volume":"29","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"2023072512154592300_BIB11","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1074\/jbc.275.2.913","volume":"275","year":"2000","journal-title":"J. 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