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The expanded Tregs express a classical cell surface phenotype and function both in vitro and in vivo to suppress effector T cell functions. Most significantly, small numbers of antigen-specific Tregs can reverse diabetes after disease onset, suggesting a novel approach to cellular immunotherapy for autoimmunity.<\/jats:p>","DOI":"10.1084\/jem.20040139","type":"journal-article","created":{"date-parts":[[2004,6,7]],"date-time":"2004-06-07T18:53:10Z","timestamp":1086634390000},"page":"1455-1465","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":1004,"title":["In Vitro\u2013expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes"],"prefix":"10.1084","volume":"199","author":[{"given":"Qizhi","family":"Tang","sequence":"first","affiliation":[{"name":"1UCSF Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143"}]},{"given":"Kammi J.","family":"Henriksen","sequence":"additional","affiliation":[{"name":"1UCSF Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143"}]},{"given":"Mingying","family":"Bi","sequence":"additional","affiliation":[{"name":"1UCSF Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143"}]},{"given":"Erik B.","family":"Finger","sequence":"additional","affiliation":[{"name":"1UCSF Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143"}]},{"given":"Greg","family":"Szot","sequence":"additional","affiliation":[{"name":"1UCSF Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143"}]},{"given":"Jianqin","family":"Ye","sequence":"additional","affiliation":[{"name":"1UCSF Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143"}]},{"given":"Emma L.","family":"Masteller","sequence":"additional","affiliation":[{"name":"1UCSF Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143"}]},{"given":"Hugh","family":"McDevitt","sequence":"additional","affiliation":[{"name":"2Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305"}]},{"given":"Mark","family":"Bonyhadi","sequence":"additional","affiliation":[{"name":"3Xcyte Therapies, Inc., Seattle, WA 98104"}]},{"given":"Jeffrey A.","family":"Bluestone","sequence":"additional","affiliation":[{"name":"1UCSF Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143"}]}],"member":"291","published-online":{"date-parts":[[2004,6,7]]},"reference":[{"key":"2023072512202757600_BIB1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.270.5238.985","volume":"270","year":"1995","journal-title":"Science."},{"key":"2023072512202757600_BIB2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/1074-7613(95)90125-6","volume":"3","year":"1995","journal-title":"Immunity."},{"key":"2023072512202757600_BIB3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1073\/pnas.90.2.770","volume":"90","year":"1993","journal-title":"Proc. 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