{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:53:35Z","timestamp":1773276815472,"version":"3.50.1"},"reference-count":47,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,3,7]]},"abstract":"<jats:p>CD4+CD25+ regulatory T (T reg) cells play a pivotal role in control of the immune response. Transforming growth factor-\u03b2 (TGF-\u03b2) has been shown to be required for T reg cell activity; however, precisely how it is involved in the mechanism of suppression is poorly understood. Using the T cell transfer model of colitis, we show here that CD4+CD45RBhigh T cells that express a dominant negative TGF-\u03b2 receptor type II (dnT\u03b2RII) and therefore cannot respond to TGF-\u03b2, escape control by T reg cells in vivo. CD4+CD25+ T reg cells from the thymus of dnT\u03b2RII mice retain the ability to inhibit colitis, suggesting that T cell responsiveness to TGF-\u03b2 is not required for the development or peripheral function of thymic-derived T reg cells. In contrast, T reg cell activity among the peripheral dnT\u03b2RII CD4+CD25+ population is masked by the presence of colitogenic effector cells that cannot be suppressed. Finally, we show that CD4+CD25+ T reg cells develop normally in the absence of TGF-\u03b21 and retain the ability to suppress colitis in vivo. Importantly, the function of TGF-\u03b21\u2212\/\u2212 T reg cells was abrogated by anti\u2013TGF-\u03b2 monoclonal antibody, indicating that functional TGF-\u03b2 can be provided by a non\u2013T reg cell source.<\/jats:p>","DOI":"10.1084\/jem.20040685","type":"journal-article","created":{"date-parts":[[2005,3,7]],"date-time":"2005-03-07T14:38:03Z","timestamp":1110206283000},"page":"737-746","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":369,"title":["T cells that cannot respond to TGF-\u03b2 escape control by CD4+CD25+ regulatory T cells"],"prefix":"10.1084","volume":"201","author":[{"given":"Linda","family":"Fahle\u0301n","sequence":"first","affiliation":[{"name":"1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK"}]},{"given":"Simon","family":"Read","sequence":"additional","affiliation":[{"name":"1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK"}]},{"given":"Leonid","family":"Gorelik","sequence":"additional","affiliation":[{"name":"2Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520"}]},{"given":"Stephen D.","family":"Hurst","sequence":"additional","affiliation":[{"name":"3Department of Immunology, Genentech, South San Francisco, CA 94080"}]},{"given":"Robert L.","family":"Coffman","sequence":"additional","affiliation":[{"name":"4Dynavax Technologies Corporation, Berkeley, CA 94710"}]},{"given":"Richard A.","family":"Flavell","sequence":"additional","affiliation":[{"name":"2Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520"}]},{"given":"Fiona","family":"Powrie","sequence":"additional","affiliation":[{"name":"1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK"}]}],"member":"291","published-online":{"date-parts":[[2005,3,7]]},"reference":[{"key":"2023072513000662900_BIB1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ni0901-816","volume":"2","year":"2001","journal-title":"Nat. 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