{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:11:10Z","timestamp":1770059470089,"version":"3.49.0"},"reference-count":47,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,11,1]]},"abstract":"<jats:p>Interleukin (IL)-7 is a stromal cell\u2013derived cytokine required for the survival, proliferation, and differentiation of B cell precursors. Members of the Bcl-2 family of proteins are known to have profound effects on lymphocyte survival, but not lymphocyte differentiation. To distinguish the relative dependence on IL-7 of B cell precursor survival versus B cell differentiation, the combined effects of lack of IL-7 and lack of the proapoptotic Bcl-2 relative, Bim, were studied. Bim is expressed to varying degrees in all B cell precursors and B cells. Lack of Bim compensated for lack of IL-7 in the survival of pro\u2013, pre\u2013, and immature B cells; however, lack of Bim did not substitute for the requirement for IL-7 in B cell precursor differentiation or B cell precursor proliferation. Precursor B cell survival is more dependent on sufficient levels of IL-7 than precursor B cell differentiation because the number of B cells and their precursors were reduced by half in mice heterozygous for IL-7 expression, but were restored to normal numbers in mice also lacking Bim. Hence, Bim and IL-7 work together to control the survival of B cell precursors and the number of B cells that exist in animals.<\/jats:p>","DOI":"10.1084\/jem.20041129","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T16:52:52Z","timestamp":1099414372000},"page":"1179-1187","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Loss of Bim Allows Precursor B Cell Survival But Not Precursor B Cell Differentiation in the Absence of Interleukin 7"],"prefix":"10.1084","volume":"200","author":[{"given":"Paula M.","family":"Oliver","sequence":"first","affiliation":[{"name":"1Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Wang","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80206"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Zhu","sequence":"additional","affiliation":[{"name":"5Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, CO 80206"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"White","sequence":"additional","affiliation":[{"name":"1Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kappler","sequence":"additional","affiliation":[{"name":"1Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center"},{"name":"3Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80206"},{"name":"4Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80206"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippa","family":"Marrack","sequence":"additional","affiliation":[{"name":"1Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center"},{"name":"3Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80206"},{"name":"5Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, CO 80206"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2004,11,1]]},"reference":[{"key":"2023072512472982600_BIB1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S1074-7613(00)80268-X","volume":"5","year":"1996","journal-title":"Immunity."},{"key":"2023072512472982600_BIB2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S1074-7613(00)80186-7","volume":"12","year":"2000","journal-title":"Immunity."},{"key":"2023072512472982600_BIB3","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.173.5.1213","volume":"173","year":"1991","journal-title":"J. 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