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Soon after HIV-1 exposure, both PDCs and MDCs were able to transfer the virus to T cells in the absence of a productive infection. However, once a productive infection was established in the DCs, newly synthesized virus was predominantly spread to T cells. HIV-1 exposure of the MDCs and PDCs did not inhibit their ability to present cytomegalovirus (CMV) antigens and activate CMV-specific memory T cells. As a result, both PDCs and MDCs preferentially transmitted HIV-1 to the responding CMV antigen\u2013specific CD4+ T cells rather than to nonresponding T cells. This suggests that the induction of antigen-specific T cell responses by DCs, a process crucial to immune defense, can lead to preferential HIV-1 infection and the deletion of responding CD4+ T cells.<\/jats:p>","DOI":"10.1084\/jem.20042413","type":"journal-article","created":{"date-parts":[[2005,6,20]],"date-time":"2005-06-20T20:13:12Z","timestamp":1119298392000},"page":"2023-2033","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":161,"title":["Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4<b>+<\/b> T cells"],"prefix":"10.1084","volume":"201","author":[{"given":"Karin","family":"Lore\u0301","sequence":"first","affiliation":[{"name":"1Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"}]},{"given":"Anna","family":"Smed-So\u0308rensen","sequence":"additional","affiliation":[{"name":"3Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, S-141 86 Stockholm, Sweden"}]},{"given":"Jayanand","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"1Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"}]},{"given":"John R.","family":"Mascola","sequence":"additional","affiliation":[{"name":"2BSL-3 Core Virology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"}]},{"given":"Richard A.","family":"Koup","sequence":"additional","affiliation":[{"name":"1Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"}]}],"member":"291","published-online":{"date-parts":[[2005,6,20]]},"reference":[{"key":"2023072512530804100_BIB1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/417095a","volume":"417","year":"2002","journal-title":"Nature."},{"key":"2023072512530804100_BIB2","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1126\/science.286.5443.1353","volume":"286","year":"1999","journal-title":"Science."},{"key":"2023072512530804100_BIB3","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1126\/science.285.5431.1261","volume":"285","year":"1999","journal-title":"Science."},{"key":"2023072512530804100_BIB4","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1073\/pnas.0308425101","volume":"101","year":"2004","journal-title":"Proc. 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