{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:39:21Z","timestamp":1772127561723,"version":"3.50.1"},"reference-count":60,"publisher":"Rockefeller University Press","issue":"12","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,12,19]]},"abstract":"<jats:p>We examined the distribution of single nucleotide polymorphisms (SNPs) in nitric oxide synthase 2A, monocyte chemoattractant protein\u20131 (MCP-1), regulated on activation, normal T cell expressed and secreted, and macrophage inflammatory protein\u20131\u03b1 genes in tuberculosis patients and healthy controls from Mexico. The odds of developing tuberculosis were 2.3- and 5.4-fold higher in carriers of MCP-1 genotypes AG and GG than in homozygous AA. Cases of homozygous GG had the highest plasma levels of MCP-1 and the lowest plasma levels of IL-12p40, and these values were negatively correlated. Furthermore, stimulation of monocytes from healthy carriers of the genotype GG with Mycobacterium tuberculosis antigens yielded higher MCP-1 and lower IL-12p40 concentrations than parallel experiments with monocytes from homozygous AA. Addition of anti\u2013MCP-1 increased IL-12p40 levels in cultures of M. tuberculosis\u2013stimulated monocytes from homozygous GG, and addition of exogenous MCP-1 reduced IL-12p40 production by M. tuberculosis\u2013stimulated monocytes from homozygous AA. Furthermore, we could replicate our results in Korean subjects, in whom the odds of developing tuberculosis were 2.8- and 6.9-fold higher in carriers of MCP-1 genotypes AG and GG than in homozygous AA. Our findings suggest that persons bearing the MCP-1 genotype GG produce high concentrations of MCP-1, which inhibits production of IL-12p40 in response to M. tuberculosis and increases the likelihood that M. tuberculosis infection will progress to active pulmonary tuberculosis.<\/jats:p>","DOI":"10.1084\/jem.20050126","type":"journal-article","created":{"date-parts":[[2005,12,14]],"date-time":"2005-12-14T02:38:42Z","timestamp":1134527922000},"page":"1649-1658","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":192,"title":["A functional promoter polymorphism in <i>monocyte chemoattractant protein\u20131<\/i> is associated with increased susceptibility to pulmonary tuberculosis"],"prefix":"10.1084","volume":"202","author":[{"given":"Pedro O.","family":"Flores-Villanueva","sequence":"first","affiliation":[{"name":"1Center for Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708"}]},{"given":"Jorge A.","family":"Ruiz-Morales","sequence":"additional","affiliation":[{"name":"1Center for Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708"}]},{"given":"Chang-Hwa","family":"Song","sequence":"additional","affiliation":[{"name":"2Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301-747, South Korea"}]},{"given":"Ludmila M.","family":"Flores","sequence":"additional","affiliation":[{"name":"3Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02115"}]},{"given":"Eun-Kyeong","family":"Jo","sequence":"additional","affiliation":[{"name":"2Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301-747, South Korea"}]},{"given":"Marta","family":"Montan\u0303o","sequence":"additional","affiliation":[{"name":"4Mexican Institute of Respiratory Diseases, Mexico D.F. 14080, Mexico"}]},{"given":"Peter F.","family":"Barnes","sequence":"additional","affiliation":[{"name":"1Center for Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708"}]},{"given":"Moises","family":"Selman","sequence":"additional","affiliation":[{"name":"4Mexican Institute of Respiratory Diseases, Mexico D.F. 14080, Mexico"}]},{"given":"Julio","family":"Granados","sequence":"additional","affiliation":[{"name":"5Department of Immunology and Rheumatology, Mexican National Institute of Medicine and Nutrition \u201cSalvador Zubiran,\u201d Mexico D.F. 14000, Mexico"}]}],"member":"291","published-online":{"date-parts":[[2005,12,13]]},"reference":[{"key":"2023072513073303400_BIB1","first-page":"549","volume":"47","year":"1942","journal-title":"Am. 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