{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T08:47:35Z","timestamp":1776242855767,"version":"3.50.1"},"reference-count":57,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,4,17]]},"abstract":"<jats:p>Tumor-associated macrophages are a prominent component of ovarian cancer stroma and contribute to tumor progression. B7-H4 is a recently identified B7 family molecule. We show that primary ovarian tumor cells express intracellular B7-H4, whereas a fraction of tumor macrophages expresses surface B7-H4. B7-H4+ tumor macrophages, but not primary ovarian tumor cells, suppress tumor-associated antigen-specific T cell immunity. Blocking B7-H4-, but not arginase-, inducible nitric oxide synthase or B7-H1 restored the T cell stimulating capacity of the macrophages and contributes to tumor regression in vivo. Interleukin (IL)-6 and IL-10 are found in high concentrations in the tumor microenvironment. These cytokines stimulate macrophage B7-H4 expression. In contrast, granulocyte\/macrophage colony-stimulating factor and IL-4, which are limited in the tumor microenvironment, inhibit B7-H4 expression. Ectopic expression of B7-H4 makes normal macrophages suppressive. Thus, B7-H4+ tumor macrophages constitute a novel suppressor cell population in ovarian cancer. B7-H4 expression represents a critical checkpoint in determining host responses to dysfunctional cytokines in ovarian cancer. Blocking B7-H4 or depleting B7-H4+ tumor macrophages may represent novel strategies to enhance T cell tumor immunity in cancer.<\/jats:p>","DOI":"10.1084\/jem.20050930","type":"journal-article","created":{"date-parts":[[2006,4,11]],"date-time":"2006-04-11T00:33:39Z","timestamp":1144715619000},"page":"871-881","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":599,"title":["B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma"],"prefix":"10.1084","volume":"203","author":[{"given":"Ilona","family":"Kryczek","sequence":"first","affiliation":[{"name":"1Department of Surgery, University of Michigan, Ann Arbor, MI 48109"},{"name":"2Tulane University Health Sciences Center, New Orleans, LA 70112"}]},{"given":"Linhua","family":"Zou","sequence":"additional","affiliation":[{"name":"1Department of Surgery, University of Michigan, Ann Arbor, MI 48109"},{"name":"2Tulane University Health Sciences Center, New Orleans, LA 70112"}]},{"given":"Paulo","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"3Louisianna State University Health Sciences Center, New Orleans, LA 70112"}]},{"given":"Gefeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"4Department of Dermatology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD 21287"}]},{"given":"Shuang","family":"Wei","sequence":"additional","affiliation":[{"name":"1Department of Surgery, University of Michigan, Ann Arbor, MI 48109"},{"name":"2Tulane University Health Sciences Center, New Orleans, LA 70112"}]},{"given":"Peter","family":"Mottram","sequence":"additional","affiliation":[{"name":"2Tulane University Health Sciences Center, New Orleans, LA 70112"}]},{"given":"Michael","family":"Brumlik","sequence":"additional","affiliation":[{"name":"2Tulane University Health Sciences Center, New Orleans, LA 70112"}]},{"given":"Pui","family":"Cheng","sequence":"additional","affiliation":[{"name":"2Tulane University Health Sciences Center, New Orleans, LA 70112"}]},{"given":"Tyler","family":"Curiel","sequence":"additional","affiliation":[{"name":"2Tulane University Health Sciences Center, New Orleans, LA 70112"}]},{"given":"Leann","family":"Myers","sequence":"additional","affiliation":[{"name":"2Tulane University Health Sciences Center, New Orleans, LA 70112"}]},{"given":"Andrew","family":"Lackner","sequence":"additional","affiliation":[{"name":"2Tulane University Health Sciences Center, New Orleans, LA 70112"}]},{"given":"Xavier","family":"Alvarez","sequence":"additional","affiliation":[{"name":"2Tulane University Health Sciences Center, New Orleans, LA 70112"}]},{"given":"Augusto","family":"Ochoa","sequence":"additional","affiliation":[{"name":"3Louisianna State University Health Sciences Center, New Orleans, LA 70112"}]},{"given":"Lieping","family":"Chen","sequence":"additional","affiliation":[{"name":"4Department of Dermatology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD 21287"}]},{"given":"Weiping","family":"Zou","sequence":"additional","affiliation":[{"name":"1Department of Surgery, University of Michigan, Ann Arbor, MI 48109"},{"name":"2Tulane University Health Sciences Center, New Orleans, LA 70112"}]}],"member":"291","published-online":{"date-parts":[[2006,4,10]]},"reference":[{"key":"2023072513344870600_BIB1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S1074-7613(02)00480-6","volume":"17","year":"2002","journal-title":"Immunity."},{"key":"2023072513344870600_BIB2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ni1029","volume":"5","year":"2004","journal-title":"Nat. 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