{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:29:22Z","timestamp":1772137762699,"version":"3.50.1"},"reference-count":35,"publisher":"Rockefeller University Press","issue":"10","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,11,21]]},"abstract":"<jats:p>The lungs are frequently challenged by viruses, and resident CD8+ T cells likely contribute to the surveillance of these pathogens. To obtain insight into local T cell immunity to respiratory viruses in humans, we determined the specificity, phenotype, and function of lung-residing CD8+ T cells and peripheral blood CD8+ T cells in a paired analysis. The lung contained markedly higher frequencies of influenza (FLU)-specific and respiratory syncytial virus (RSV)-specific CD8+ T cells when compared with the circulation. This contrasted with an equal distribution of cytomegalovirus- and Epstein-Bar virus\u2013specific CD8+ T cells. Noticeably, a substantial fraction of the lung-residing FLU- and RSV-specific CD8+ T cells had progressed to a relatively late differentiation phenotype, reflected by low expression of CD28 and CD27. Lung-derived FLU-specific CD8+ T cells had low activation requirements, as expansion of these cells could be initiated by cognate peptide in the absence of helper cell\u2013derived signals. Thus, the human lung contains high numbers of differentiated FLU- and RSV-specific memory CD8+ T cells that can readily expand upon reexposure to virus. Resident lung T cells may provide immediate immunological protection against pulmonary virus infections.<\/jats:p>","DOI":"10.1084\/jem.20051365","type":"journal-article","created":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T19:19:18Z","timestamp":1132600758000},"page":"1433-1442","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":144,"title":["Selective accumulation of differentiated CD8\n                    <b>+<\/b>\n                    T cells specific for respiratory viruses in the human lung"],"prefix":"10.1084","volume":"202","author":[{"given":"Godelieve J.","family":"de Bree","sequence":"first","affiliation":[{"name":"1Department of Pulmonology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, Netherlands"},{"name":"2Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, Netherlands"}]},{"given":"Ester M.M.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"2Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, Netherlands"},{"name":"3Department of Nephrology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, Netherlands"}]},{"given":"Theo A.","family":"Out","sequence":"additional","affiliation":[{"name":"2Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, Netherlands"}]},{"given":"Henk M.","family":"Jansen","sequence":"additional","affiliation":[{"name":"1Department of Pulmonology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, Netherlands"}]},{"given":"Rene\u0301 E.","family":"Jonkers","sequence":"additional","affiliation":[{"name":"1Department of Pulmonology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, Netherlands"}]},{"given":"Rene\u0301 A.W.","family":"van Lier","sequence":"additional","affiliation":[{"name":"2Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, Netherlands"}]}],"member":"291","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"2023072513052737700_BIB1","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1056\/NEJMoa032158","volume":"350","year":"2004","journal-title":"N. 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