{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:29:23Z","timestamp":1772137763403,"version":"3.50.1"},"reference-count":29,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,5,15]]},"abstract":"<jats:p>The introduction of antigen into animals causes antigen-specific T cells to divide and then die. Activated T cell death requires either of the death effector molecules, Bak or Bax. When T cells die, Bak and Bax change their conformations, a phenomenon that is thought to be required for Bak or Bax to drive cell death. Here we show that Bak changes conformation before activated T cells die, as detected by an antibody specific for a peptide near the NH2 terminus of Bak, but Bax does not change its shape markedly until after the cells are dead, as detected by an antibody specific for a peptide near the NH2 terminus of Bax. This latter finding is also true in activated T cells that lack Bak and are therefore dependent on Bax to die. This result suggests that Bax does not have to adopt its final, completely unfolded form until after the cells are dead.<\/jats:p>","DOI":"10.1084\/jem.20051736","type":"journal-article","created":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T20:19:28Z","timestamp":1146514768000},"page":"1147-1152","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Bax does not have to adopt its final form to drive T cell death"],"prefix":"10.1084","volume":"203","author":[{"given":"Yanan","family":"Zhu","sequence":"first","affiliation":[{"name":"1Department of Biochemistry and Molecular Genetics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinqi","family":"Liu","sequence":"additional","affiliation":[{"name":"4Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hildeman","sequence":"additional","affiliation":[{"name":"5Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred W.","family":"Peyerl","sequence":"additional","affiliation":[{"name":"4Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"White","sequence":"additional","affiliation":[{"name":"4Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elenora","family":"Kushnir","sequence":"additional","affiliation":[{"name":"4Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kappler","sequence":"additional","affiliation":[{"name":"2Department of Pharmacology,"},{"name":"3Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80220"},{"name":"4Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippa","family":"Marrack","sequence":"additional","affiliation":[{"name":"1Department of Biochemistry and Molecular Genetics"},{"name":"3Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80220"},{"name":"4Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"2023072513483791300_BIB1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrc883","volume":"2","year":"2002","journal-title":"Nat. Rev. Cancer."},{"key":"2023072513483791300_BIB2","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/ni0503-410","volume":"4","year":"2003","journal-title":"Nat. Immunol."},{"key":"2023072513483791300_BIB3","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1099320","volume":"305","year":"2004","journal-title":"Science."},{"key":"2023072513483791300_BIB4","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S1097-2765(00)00136-2","volume":"6","year":"2000","journal-title":"Mol. Cell."},{"key":"2023072513483791300_BIB5","first-page":"932","volume":"3","year":"2002","journal-title":"Nat. Immunol."},{"key":"2023072513483791300_BIB6","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1097-2765(01)00320-3","volume":"8","year":"2001","journal-title":"Mol. Cell."},{"key":"2023072513483791300_BIB7","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1093\/emboj\/17.14.3878","volume":"17","year":"1998","journal-title":"EMBO J."},{"key":"2023072513483791300_BIB8","doi-asserted-by":"crossref","first-page":"10777","DOI":"10.1074\/jbc.273.17.10777","volume":"273","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2023072513483791300_BIB9","doi-asserted-by":"crossref","first-page":"7668","DOI":"10.1038\/sj.onc.1204995","volume":"20","year":"2001","journal-title":"Oncogene."},{"key":"2023072513483791300_BIB10","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1083\/jcb.200309013","volume":"164","year":"2004","journal-title":"J. Cell Biol."},{"key":"2023072513483791300_BIB11","doi-asserted-by":"crossref","first-page":"13829","DOI":"10.1074\/jbc.272.21.13829","volume":"272","year":"1997","journal-title":"J. Biol. Chem."},{"key":"2023072513483791300_BIB12","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1126\/science.277.5324.370","volume":"277","year":"1997","journal-title":"Science."},{"key":"2023072513483791300_BIB13","doi-asserted-by":"crossref","first-page":"11357","DOI":"10.1073\/pnas.94.21.11357","volume":"94","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072513483791300_BIB14","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1126\/science.281.5385.2027","volume":"281","year":"1998","journal-title":"Science."},{"key":"2023072513483791300_BIB15","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1128\/MCB.20.5.1604-1615.2000","volume":"20","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"2023072513483791300_BIB16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(02)01036-X","volume":"111","year":"2002","journal-title":"Cell."},{"key":"2023072513483791300_BIB17","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1038\/sj.emboj.7600675","volume":"24","year":"2005","journal-title":"EMBO J."},{"key":"2023072513483791300_BIB18","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1093\/emboj\/18.9.2330","volume":"18","year":"1999","journal-title":"EMBO J."},{"key":"2023072513483791300_BIB19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/1074-7613(94)90084-1","volume":"1","year":"1994","journal-title":"Immunity."},{"key":"2023072513483791300_BIB20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0952-7915(94)90129-5","volume":"6","year":"1994","journal-title":"Curr. Opin. Immunol."},{"key":"2023072513483791300_BIB21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/1074-7613(95)90050-0","volume":"2","year":"1995","journal-title":"Immunity."},{"key":"2023072513483791300_BIB22","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/415922a","volume":"415","year":"2002","journal-title":"Nature."},{"key":"2023072513483791300_BIB23","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1084\/jem.20020827","volume":"196","year":"2002","journal-title":"J. Exp. Med."},{"key":"2023072513483791300_BIB24","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S1074-7613(02)00322-9","volume":"16","year":"2002","journal-title":"Immunity."},{"key":"2023072513483791300_BIB25","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0092-8674(00)00167-7","volume":"103","year":"2000","journal-title":"Cell."},{"key":"2023072513483791300_BIB26","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.2970670","volume":"241","year":"1988","journal-title":"Science."},{"key":"2023072513483791300_BIB27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1126\/science.270.5233.96","volume":"270","year":"1995","journal-title":"Science."},{"key":"2023072513483791300_BIB28","doi-asserted-by":"crossref","first-page":"7681","DOI":"10.1073\/pnas.0402293101","volume":"101","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072513483791300_BIB29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S1074-7613(00)80072-2","volume":"10","year":"1999","journal-title":"Immunity."}],"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/203\/5\/1147\/1722165\/1147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/203\/5\/1147\/1722165\/1147.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T09:49:09Z","timestamp":1690278549000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/203\/5\/1147\/54502\/Bax-does-not-have-to-adopt-its-final-form-to-drive"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,1]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5,15]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20051736","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1032228.372887","asserted-by":"object"}]},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5,1]]}}}