{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:27:01Z","timestamp":1778876821767,"version":"3.51.4"},"reference-count":43,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,2,20]]},"abstract":"<jats:p>Mast cells are pivotal effector cells in IgE-mediated allergic inflammatory diseases. Central for mast cell activation are signals from the IgE receptor Fc\u03b5RI, which induce cell degranulation with the release of preformed mediators and de novo synthesis of proinflammatory leukotrienes and cytokines. How these individual mast cell responses are differentially controlled is still unresolved. We identify B cell lymphoma 10 (Bcl10) and mucosa-associated lymphoid tissue 1 (Malt1) as novel key regulators of mast cell signaling. Mice deficient for either protein display severely impaired IgE-dependent late phase anaphylactic reactions. Mast cells from these animals neither activate nuclear factor \u03baB (NF-\u03baB) nor produce tumor necrosis factor \u03b1 or interleukin 6 upon Fc\u03b5RI ligation even though proximal signaling, degranulation, and leukotriene secretion are normal. Thus, Bcl10 and Malt1 are essential positive mediators of Fc\u03b5RI-dependent mast cell activation that selectively uncouple NF-\u03baB\u2013induced proinflammatory cytokine production from degranulation and leukotriene synthesis.<\/jats:p>","DOI":"10.1084\/jem.20051982","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T20:53:46Z","timestamp":1138049626000},"page":"337-347","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":113,"title":["The Bcl10\u2013Malt1 complex segregates Fc\u03b5RI-mediated nuclear factor \u03baB activation and cytokine production from mast cell degranulation"],"prefix":"10.1084","volume":"203","author":[{"given":"Stefanie","family":"Klemm","sequence":"first","affiliation":[{"name":"1Third Medical Department, Klinikum rechts der Isar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Gutermuth","sequence":"additional","affiliation":[{"name":"3ZAUM-Center for Allergy and Environment, Technical University of Munich and Division of Environmental Dermatology and Allergy, GSF\u2013National Research Center for Environment and Health, 80802 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lothar","family":"Hu\u0308ltner","sequence":"additional","affiliation":[{"name":"4Institute of Clinical Molecular Biology and Tumor Genetics, GSF\u2013National Research Center for Environment and Health, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Sparwasser","sequence":"additional","affiliation":[{"name":"2Institute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidrun","family":"Behrendt","sequence":"additional","affiliation":[{"name":"3ZAUM-Center for Allergy and Environment, Technical University of Munich and Division of Environmental Dermatology and Allergy, GSF\u2013National Research Center for Environment and Health, 80802 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Peschel","sequence":"additional","affiliation":[{"name":"1Third Medical Department, Klinikum rechts der Isar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tak W.","family":"Mak","sequence":"additional","affiliation":[{"name":"5The Campbell Family Institute for Breast Cancer Research and Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, Ontario, M5G 2C1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thilo","family":"Jakob","sequence":"additional","affiliation":[{"name":"3ZAUM-Center for Allergy and Environment, Technical University of Munich and Division of Environmental Dermatology and Allergy, GSF\u2013National Research Center for Environment and Health, 80802 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u0308rgen","family":"Ruland","sequence":"additional","affiliation":[{"name":"1Third Medical Department, Klinikum rechts der Isar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2006,1,23]]},"reference":[{"key":"2023072513462903400_BIB1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.immunol.21.120601.141025","volume":"23","year":"2005","journal-title":"Annu. 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