{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:33:09Z","timestamp":1772119989263,"version":"3.50.1"},"reference-count":59,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,3,19]]},"abstract":"<jats:p>Various T cell adhesion molecules and their cognate receptors on target cells promote T cell receptor (TCR)\u2013mediated cell killing. In this report, we demonstrate that the interaction of epithelial cell marker E-cadherin with integrin \u03b1E(CD103)\u03b27, often expressed by tumor-infiltrating lymphocytes (TILs), plays a major role in effective tumor cell lysis. Indeed, we found that although tumor-specific CD103+ TIL-derived cytotoxic T lymphocyte (CTL) clones are able to kill E-cadherin+\/intercellular adhesion molecule 1\u2212 autologous tumor cells, CD103\u2212 peripheral blood lymphocyte (PBL)-derived counterparts are inefficient. This cell killing is abrogated after treatment of the TIL clones with a blocking anti-CD103 monoclonal antibody or after targeting E-cadherin in the tumor using ribonucleic acid interference. Confocal microscopy analysis also demonstrated that \u03b1E\u03b27 is recruited at the immunological synapse and that its interaction with E-cadherin is required for cytolytic granule polarization and subsequent exocytosis. Moreover, we report that the CD103\u2212 profile, frequently observed in PBL-derived CTL clones and associated with poor cytotoxicity against the cognate tumor, is up-regulated upon TCR engagement and transforming growth factor \u03b21 treatment, resulting in strong potentiation of antitumor lytic function. Thus, CD8+\/CD103+ tumor-reactive T lymphocytes infiltrating epithelial tumors most likely play a major role in antitumor cytotoxic response through \u03b1E\u03b27\u2013E-cadherin interactions.<\/jats:p>","DOI":"10.1084\/jem.20061524","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T01:34:36Z","timestamp":1172540076000},"page":"559-570","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":235,"title":["\u03b1E\u03b27 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis"],"prefix":"10.1084","volume":"204","author":[{"given":"Audrey Le","family":"Floc'h","sequence":"first","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U753"}]},{"given":"Abdelali","family":"Jalil","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U753"}]},{"given":"Isabelle","family":"Vergnon","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U753"}]},{"given":"Be\u0301atrice Le Maux","family":"Chansac","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U753"}]},{"given":"Vladimir","family":"Lazar","sequence":"additional","affiliation":[{"name":"2Unite\u0301 de ge\u0301nomique fonctionnelle, Institut Fe\u0301de\u0301ratif de Recherche (IFR)-54, Institut Gustave Roussy, Villejuif Cedex 94805, France"}]},{"given":"Georges","family":"Bismuth","sequence":"additional","affiliation":[{"name":"3INSERM U567, Centre National de la Recherche Scientifique (CNRS), Universite\u0301 Rene\u0301 Descartes, 75014 Paris, France"}]},{"given":"Salem","family":"Chouaib","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U753"}]},{"given":"Fathia","family":"Mami-Chouaib","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U753"}]}],"member":"291","published-online":{"date-parts":[[2007,2,26]]},"reference":[{"key":"2023072515554122800_BIB1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1034\/j.1600-065X.2002.18913.x","volume":"189","year":"2002","journal-title":"Immunol. 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