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By performing T cell transfers into TCR transgenic hosts we detected a hierarchical order of homeostatic proliferation for T cells differing in MHC restriction, such that OT1 cells (Kb restricted) proliferated in P14 (Db-restricted TCR) recipients, but not vice versa. Using Kb mutant mice, we demonstrated that proliferation of OT1 cells in P14 recipients, as well as the ability of host OT1 cells to hinder the proliferation of donor P14 cells, were dependent on OT1-TCR binding to Kb molecules. However, interclonal T cell competition was not mediated simply by competition for physical access to the MHC-bearing cell. This was shown in parabiotic pairs of OT1 and Kb mutant mice in which P14 cells failed to proliferate, even though the OT1 cells could not interact with half of the APCs in the system. Thus, we conclude that the interaction between the TCR and restricting MHC molecule influences the ability to compete for trophic resources not bound to the stimulating APC. This mechanism allows a local competitiveness that extends beyond a T cell's specificity.<\/jats:p>","DOI":"10.1084\/jem.20070467","type":"journal-article","created":{"date-parts":[[2008,11,18]],"date-time":"2008-11-18T02:24:26Z","timestamp":1226975066000},"page":"2735-2743","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["T cell receptor contact to restricting MHC molecules is a prerequisite for peripheral interclonal T cell competition"],"prefix":"10.1084","volume":"205","author":[{"given":"Fabien","family":"Agene\u0300s","sequence":"first","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U548, 38054 Grenoble, Cedex 9, France"},{"name":"2INSERM U743, CR-CHUM, De\u0301partement de microbiologie et immunologie, Universite\u0301 de Montre\u0301al, Montre\u0301al H2X 1P1, Que\u0301bec, Canada"}]},{"given":"Jean-Pierre","family":"Dangy","sequence":"additional","affiliation":[{"name":"3Basel Institute for Immunology, 4005 Basel, Switzerland"}]},{"given":"Jo\u0308rg","family":"Kirberg","sequence":"additional","affiliation":[{"name":"3Basel Institute for Immunology, 4005 Basel, Switzerland"},{"name":"4Max-Planck-Institute of Immunobiology, 79108 Freiburg, Germany"}]}],"member":"291","published-online":{"date-parts":[[2008,11,17]]},"reference":[{"key":"2023072916381503200_BIB1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/intimm\/10.3.305","volume":"10","year":"1998","journal-title":"Int. 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