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DC priming with interferon (IFN) \u03b3 strongly increased IL-12 production, but was not required for IL-23 production and inhibited IL-23 production induced by \u03b2-glucan. The pattern of IL-12 and IL-23 induction was reflected in accumulation of the IL-12p35 and IL-23p19 transcripts, respectively, but not IL-12\/23p40. Although IL-23, transforming growth factor \u03b2, and IL-6 contained in the supernatants of activated mono-DCs played a role in the induction of IL-17 by human CD4+ T cells, IL-1\u03b2, in combination with one or more of those factors, was required for IL-17 production, and its production determined the differential ability of the stimuli used to elicit mono-DCs to produce soluble factors directing IL-17 production. 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