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This T cell expansion caused a significant broadening of circulating T cell receptor (TCR) repertoire diversity independent of the subjects' age as naive T cells, including recent thymic emigrants (RTEs), expanded preferentially, whereas the proportions of regulatory T (T reg) cells and senescent CD8+ effectors diminished. The resulting composition of the circulating T cell pool more closely resembled that seen earlier in life. This profile, distinctive among cytokines under clinical development, suggests that rhIL-7 therapy could enhance and broaden immune responses, particularly in individuals with limited naive T cells and diminished TCR repertoire diversity, as occurs after physiological (age), pathological (human immunodeficiency virus), or iatrogenic (chemotherapy) lymphocyte depletion.<\/jats:p>","DOI":"10.1084\/jem.20071681","type":"journal-article","created":{"date-parts":[[2008,6,24]],"date-time":"2008-06-24T00:55:33Z","timestamp":1214268933000},"page":"1701-1714","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":405,"title":["Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets"],"prefix":"10.1084","volume":"205","author":[{"given":"Claude","family":"Sporte\u0300s","sequence":"first","affiliation":[{"name":"1Experimental Transplantation and Immunology Branch;"}]},{"given":"Frances T.","family":"Hakim","sequence":"additional","affiliation":[{"name":"1Experimental Transplantation and Immunology Branch;"}]},{"given":"Sarfraz A.","family":"Memon","sequence":"additional","affiliation":[{"name":"1Experimental Transplantation and Immunology Branch;"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"2Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute;"}]},{"given":"Kevin S.","family":"Chua","sequence":"additional","affiliation":[{"name":"2Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute;"}]},{"given":"Margaret R.","family":"Brown","sequence":"additional","affiliation":[{"name":"4Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892"}]},{"given":"Thomas A.","family":"Fleisher","sequence":"additional","affiliation":[{"name":"4Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892"}]},{"given":"Michael C.","family":"Krumlauf","sequence":"additional","affiliation":[{"name":"1Experimental Transplantation and Immunology Branch;"}]},{"given":"Rebecca R.","family":"Babb","sequence":"additional","affiliation":[{"name":"1Experimental Transplantation and Immunology Branch;"}]},{"given":"Catherine K.","family":"Chow","sequence":"additional","affiliation":[{"name":"3Departments of Radiology;"}]},{"given":"Terry J.","family":"Fry","sequence":"additional","affiliation":[{"name":"2Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute;"}]},{"given":"Julie","family":"Engels","sequence":"additional","affiliation":[{"name":"5Cytheris Inc., Rockville, MD 20850"}]},{"given":"Renaud","family":"Buffet","sequence":"additional","affiliation":[{"name":"5Cytheris Inc., Rockville, MD 20850"}]},{"given":"Michel","family":"Morre","sequence":"additional","affiliation":[{"name":"5Cytheris Inc., Rockville, MD 20850"}]},{"given":"Robert J.","family":"Amato","sequence":"additional","affiliation":[{"name":"6Methodist Hospital, Texas Medical Center, Houston, TX 77021"}]},{"given":"David J.","family":"Venzon","sequence":"additional","affiliation":[{"name":"7Biostatistics and Data Management Section, National Cancer Institute,"}]},{"given":"Robert","family":"Korngold","sequence":"additional","affiliation":[{"name":"8The Cancer Center at Hackensack University Medical Center, Hackensack, NJ 07601"}]},{"given":"Andrew","family":"Pecora","sequence":"additional","affiliation":[{"name":"8The Cancer Center at Hackensack University Medical Center, Hackensack, NJ 07601"}]},{"given":"Ronald E.","family":"Gress","sequence":"additional","affiliation":[{"name":"1Experimental Transplantation and Immunology Branch;"}]},{"given":"Crystal L.","family":"Mackall","sequence":"additional","affiliation":[{"name":"2Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute;"}]}],"member":"291","published-online":{"date-parts":[[2008,6,23]]},"reference":[{"key":"2023072916141938600_BIB1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nm866","volume":"9","year":"2003","journal-title":"Nat. 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