{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:36:11Z","timestamp":1767339371234},"reference-count":45,"publisher":"Rockefeller University Press","issue":"12","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,11,23]]},"abstract":"<jats:p>B cell activation factor of the TNF family (BAFF) activates noncanonical nuclear factor \u03baB (NF-\u03baB) heterodimers that promote B cell survival. We show that although MALT1 is largely dispensable for canonical NF-\u03baB signaling downstream of the B cell receptor, the absence of MALT1 results in impaired BAFF-induced phosphorylation of NF-\u03baB2 (p100), p100 degradation, and RelB nuclear translocation in B220+ B cells. This corresponds with impaired survival of MALT1\u2212\/\u2212 marginal zone (MZ) but not follicular B cells in response to BAFF stimulation in vitro. MALT1\u2212\/\u2212 MZ B cells also express higher amounts of TRAF3, a known negative regulator of BAFF receptor\u2013mediated signaling, and TRAF3 was found to interact with MALT1. Furthermore, phenotypes associated with overexpression of BAFF, including increased MZ B cell numbers, elevated serum immunoglobulin titers, and spontaneous germinal center formation, were found to be dependent on B cell\u2013intrinsic MALT1 expression. Our results demonstrate a novel role for MALT1 in biological outcomes induced by BAFF-mediated signal transduction.<\/jats:p>","DOI":"10.1084\/jem.20091802","type":"journal-article","created":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T02:58:57Z","timestamp":1258426737000},"page":"2671-2683","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets"],"prefix":"10.1084","volume":"206","author":[{"given":"Michael W.","family":"Tusche","sequence":"first","affiliation":[{"name":"Department of Immunology 1 and 2"},{"name":"Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada 1 and 2"},{"name":"Campbell Family Institute for Cancer Research, Princess Margaret Hospital, Toronto, Ontario M5G 2C1, Canada 3"}]},{"given":"Lesley A.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Immunology 1 and 2"},{"name":"Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada 1 and 2"}]},{"given":"Frances","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Immunology 1 and 2"},{"name":"Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada 1 and 2"}]},{"given":"Doug","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Immunology 1 and 2"},{"name":"Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada 1 and 2"}]},{"given":"Miguel","family":"Quintela-Fandino","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Cancer Research, Princess Margaret Hospital, Toronto, Ontario M5G 2C1, Canada 3"}]},{"given":"Jurgen","family":"Ruland","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen, 81675 Munich, Germany 4"}]},{"given":"Jennifer L.","family":"Gommerman","sequence":"additional","affiliation":[{"name":"Department of Immunology 1 and 2"},{"name":"Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada 1 and 2"}]},{"given":"Tak W.","family":"Mak","sequence":"additional","affiliation":[{"name":"Department of Immunology 1 and 2"},{"name":"Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada 1 and 2"},{"name":"Department of Immunology 1 and 2"},{"name":"Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada 1 and 2"},{"name":"Campbell Family Institute for Cancer Research, Princess Margaret Hospital, Toronto, Ontario M5G 2C1, Canada 3"}]}],"member":"291","published-online":{"date-parts":[[2009,11,16]]},"reference":[{"key":"2023072920215518600_bib1","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.1038\/sj.onc.1203018","article-title":"A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue","volume":"18","author":"Akagi","year":"1999","journal-title":"Oncogene."},{"key":"2023072920215518600_bib2","doi-asserted-by":"publisher","first-page":"5270","DOI":"10.1158\/0008-5472.CAN-05-4590","article-title":"Selective expansion of marginal zone B cells in Emicro-API2-MALT1 mice is linked to enhanced IkappaB kinase gamma polyubiquitination","volume":"66","author":"Baens","year":"2006","journal-title":"Cancer Res."},{"key":"2023072920215518600_bib3","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1084\/jem.192.10.1453","article-title":"BAFF mediates survival of peripheral immature B lymphocytes","volume":"192","author":"Batten","year":"2000","journal-title":"J. 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