{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T14:12:31Z","timestamp":1698761551256},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1955,12,1]]},"abstract":"<jats:p>During active blood regeneration in anemia in dogs an increase occurs in the stroma protein of the red cells.<\/jats:p>\n               <jats:p>When vitamin B12 with radioactive cobalt is given at the start of this blood regeneration one finds concentration of labeled B12 in the stroma protein but not in the hemoglobin.<\/jats:p>\n               <jats:p>After the acute phase of red cell regeneration is ended the concentration of B12 in stroma protein falls rapidly to very low levels within 2 weeks. Subsequent episodes of red blood cell regeneration seems not to cause remobilization of radioactive cobalt into red cells from other body stores.<\/jats:p>\n               <jats:p>It appears that the vitamin B12 is a factor of importance in the first steps of stroma protein formation in the first few days of the life of the red cell in the dog.<\/jats:p>\n               <jats:p>This response in dogs and the response in pernicious anemia to vitamin B12 may have some points in common.<\/jats:p>\n               <jats:p>Distribution of the B12-radioactive cobalt in the organs and tissues at autopsy has been recorded. Some very suggestive localizations were noted and some variation 1 week and 7 weeks after B12 injections.<\/jats:p>\n               <jats:p>Radioactive cobalt escapes in the urine during the weeks following B12 injections.<\/jats:p>","DOI":"10.1084\/jem.102.6.725","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T18:35:50Z","timestamp":1087929350000},"page":"725-731","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["RED CELL STROMA PROTEIN RICH IN VITAMIN B12 DURING ACTIVE REGENERATION"],"prefix":"10.1084","volume":"102","author":[{"given":"G. H.","family":"Whipple","sequence":"first","affiliation":[{"name":"From the Departments of Pathology and Radiation Biology, The University of Rochester School of Medicine and Dentistry, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. S.","family":"Robscheit-Robbins","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Radiation Biology, The University of Rochester School of Medicine and Dentistry, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. F.","family":"Bale","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Radiation Biology, The University of Rochester School of Medicine and Dentistry, Rochester, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1955,12,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/102\/6\/725\/1643917\/725.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/102\/6\/725\/1643917\/725.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T17:48:49Z","timestamp":1690220929000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/102\/6\/725\/2179\/RED-CELL-STROMA-PROTEIN-RICH-IN-VITAMIN-B12-DURING"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1955,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1955,12,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.102.6.725","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1955,12,1]]}}}