{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:33:50Z","timestamp":1758634430080},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1957,7,1]]},"abstract":"<jats:p>Ten polysaccharides, isolated from various animal and plant sources, were selected for comparison with 2 bacterial polysaccharides, typical of Gram-negative endotoxins. The tissue sources were: mouse (kidney, liver, lung, stomach, Sarcoma 37, and Carcinoma 241-6); rabbit skin and chick embryo skin; and tangerine and Bryonia root. The bacterial endotoxins were those of S. typhosa and Serr. marcescens. Their relative potency was determined in inducing the following host effects: fever, tolerance to pyrogenic action, leucocytic changes, the Shwartzman reaction, damage to Sarcoma 37, dermal hemorrhagic-necrosis by epinephrine, enhancement of antibody production, and lethality.<\/jats:p>\n               <jats:p>Some of the polysaccharides were consistently active in all the host reactions studied; except for pyrogenic activity at high dosage, the other polysaccharides were consistently negative throughout. The mouse tissue polysaccharides elicited all the effects studied; in some instances their potency approached those of the bacterial polysaccharides.<\/jats:p>\n               <jats:p>It is pointed out that elicitation of the above array of biological phenomena, hitherto considered characteristic of bacterial endotoxins, can be obtained with polysaccharides from animal and plant tissues.<\/jats:p>","DOI":"10.1084\/jem.106.1.77","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"77-97","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["SIMILARITY OF HOST RESPONSES ELICITED BY POLYSACCHARIDES OF ANIMAL AND PLANT ORIGIN AND BY BACTERIAL ENDOTOXINS"],"prefix":"10.1084","volume":"106","author":[{"given":"Maurice","family":"Landy","sequence":"first","affiliation":[{"name":"From the Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray J.","family":"Shear","sequence":"additional","affiliation":[{"name":"From the Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"With the Assistance of Robert-John Trapani and Adrian Perrault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1957,7,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/106\/1\/77\/1645512\/77.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/106\/1\/77\/1645512\/77.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T18:19:15Z","timestamp":1690222755000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/106\/1\/77\/2432\/SIMILARITY-OF-HOST-RESPONSES-ELICITED-BY"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1957,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1957,7,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.106.1.77","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"type":"electronic","value":"1540-9538"},{"type":"print","value":"0022-1007"}],"subject":[],"published":{"date-parts":[[1957,7,1]]}}}