{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:42:20Z","timestamp":1773420140039,"version":"3.50.1"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1957,9,1]]},"abstract":"<jats:p>The vascular effects of lethal doses of E. coli endotoxin, as observed in the mesentery of the rat, resemble the reactions of traumatic and hemorrhagic shock in the following respects: a profound inhibition of arteriolar and precapillary reactivity to topical epinephrine occurs after an initial stage of hyperreactivity; the small veins show failure to relax completely following constrictor doses of epinephrine; and the terminal vessels develop an unusual sensitivity to fluctuations in temperature of the fluid irrigating the tissue.<\/jats:p>\n               <jats:p>Rats in which tolerance to bacterial endotoxin is induced, by repeated doses given daily, become highly resistant to the lethal effects of both drum trauma and hemorrhagic shock.<\/jats:p>\n               <jats:p>However, rats in which the adaptation to traumatic shock is produced by repeated exposure to drum trauma, do not develop a significant degree of tolerance to lethal doses of endotoxin.<\/jats:p>\n               <jats:p>The injection of small non-lethal doses of bacterial endotoxin during non-lethal episodes of trauma or hemorrhage, leads to the development of irreversible shock and death.<\/jats:p>\n               <jats:p>The bearing of these findings on the problem of the relationship between endotoxin and traumatic shock is discussed.<\/jats:p>","DOI":"10.1084\/jem.106.3.385","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"385-401","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":68,"title":["THE RELATIONSHIP BETWEEN THE VASCULAR MANIFESTATIONS OF SHOCK PRODUCED BY ENDOTOXIN, TRAUMA, AND HEMORRHAGE"],"prefix":"10.1084","volume":"106","author":[{"given":"Benjamin W.","family":"Zweifach","sequence":"first","affiliation":[{"name":"From the Department of Pathology, New York University-Bellevue Medical Center, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis","family":"Thomas","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, New York University-Bellevue Medical Center, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"With the Technical Assistance of P. Viera and C. Mikros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1957,9,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/106\/3\/385\/1645575\/385.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/106\/3\/385\/1645575\/385.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T18:22:15Z","timestamp":1690222935000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/106\/3\/385\/2453\/THE-RELATIONSHIP-BETWEEN-THE-VASCULAR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1957,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1957,9,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.106.3.385","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1957,9,1]]}}}