{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:29:57Z","timestamp":1759814997901},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1957,11,1]]},"abstract":"<jats:p>Young male rats fed an atherogenic diet for 24 to 26 days developed magnesium deficiency.<\/jats:p>\n               <jats:p>The renal lesions, calcium deposition in tubular lumens in the outer zona intermedia, are morphologically consistent with those seen in animals fed magnesium-free diets. It was necessary to feed 8 to 16 times the normal requirement of magnesium to prevent completely these lesions. The limitations in the pathogenesis of these renal lesions are discussed.<\/jats:p>\n               <jats:p>The addition of 2 mg. per cent of thyroxine to the diet markedly lowered or abolished deposition of calcium in the kidney; it also lowered atherogenesis to a minimum but did not abolish it.<\/jats:p>\n               <jats:p>Early lesions of atherosclerosis of the cardiac valves and of the aorta were observed. These were more prominent in animals on a 10 per cent than in those on a 20 per cent protein diet. The atherosclerosis was diminished but not abolished by exceedingly high dietary levels of magnesium in the 10 per cent protein group. Such a decrease was not noted in the 20 per cent protein group.<\/jats:p>\n               <jats:p>There did not appear to be significant variation in the morphology of the fatty livers in and between the various groups and subgroups as judged by staining with Sudan IV.<\/jats:p>","DOI":"10.1084\/jem.106.5.767","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"767-776","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["INFLUENCE OF DIETARY MAGNESIUM ON CARDIAC AND RENAL LESIONS OF YOUNG RATS FED AN ATHEROGENIC DIET"],"prefix":"10.1084","volume":"106","author":[{"given":"E. E.","family":"Hellerstein","sequence":"first","affiliation":[{"name":"From the Mallory Institute of Pathology, Boston City Hospital, Department of Nutrition, Harvard School of Public Health, and the Department of Pathology, Boston University School of Medicine, Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Vitale","sequence":"additional","affiliation":[{"name":"From the Mallory Institute of Pathology, Boston City Hospital, Department of Nutrition, Harvard School of Public Health, and the Department of Pathology, Boston University School of Medicine, Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. L.","family":"White","sequence":"additional","affiliation":[{"name":"From the Mallory Institute of Pathology, Boston City Hospital, Department of Nutrition, Harvard School of Public Health, and the Department of Pathology, Boston University School of Medicine, Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Hegsted","sequence":"additional","affiliation":[{"name":"From the Mallory Institute of Pathology, Boston City Hospital, Department of Nutrition, Harvard School of Public Health, and the Department of Pathology, Boston University School of Medicine, Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Zamcheck","sequence":"additional","affiliation":[{"name":"From the Mallory Institute of Pathology, Boston City Hospital, Department of Nutrition, Harvard School of Public Health, and the Department of Pathology, Boston University School of Medicine, Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nakamura","sequence":"additional","affiliation":[{"name":"From the Mallory Institute of Pathology, Boston City Hospital, Department of Nutrition, Harvard School of Public Health, and the Department of Pathology, Boston University School of Medicine, Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"With the Technical Assistance of T. Faherty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1957,11,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/106\/5\/767\/1645611\/767.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/106\/5\/767\/1645611\/767.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T18:24:06Z","timestamp":1690223046000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/106\/5\/767\/2477\/INFLUENCE-OF-DIETARY-MAGNESIUM-ON-CARDIAC-AND"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1957,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1957,11,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.106.5.767","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"type":"electronic","value":"1540-9538"},{"type":"print","value":"0022-1007"}],"subject":[],"published":{"date-parts":[[1957,11,1]]}}}