{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:11:45Z","timestamp":1756991505290},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1957,12,1]]},"abstract":"<jats:p>Experiments are described indicating that the magnitude and sensitivity of the passive cutaneous anaphylaxis (PCA) response in normal rats to a given level of immune reagents, may be enhanced by the addition of hemolytically active sera.<\/jats:p>\n               <jats:p>A similar enhancement in normal rats has been obtained with C' component reagents possessing properties associated with the third component of C'.<\/jats:p>\n               <jats:p>Parallelisms between in vitro fixation of C' and PCA induction by antigen and antibody are shown. The horse anti-pneumococcus system has low C'-fixing potencies and is also less efficient than the rabbit polysaccharide system in the induction of PCA.<\/jats:p>\n               <jats:p>Findings of a similar nature were observed in the reaction of rabbit anti-ribonuclease with ribonuclease, the acetylated and guanidinated derivatives of the enzyme.<\/jats:p>\n               <jats:p>The injection of hemolytically active serum into C'-deficient rats was accompanied by a partial restoration of PCA. Restorative effects were also noted with heated and ammonia-treated serum.<\/jats:p>\n               <jats:p>The return of hemolytic potency and responsiveness to PCA in C'-depleted rats, follow a similar time course.<\/jats:p>\n               <jats:p>The data presented indicate that the PCA reaction can be studied as a function of at least three variables, antigen, antibody, and a serum constituent resembling C'.<\/jats:p>","DOI":"10.1084\/jem.106.6.811","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"811-834","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["STUDIES ON THE MECHANISM OF HYPERSENSITIVITY PHENOMENA"],"prefix":"10.1084","volume":"106","author":[{"given":"Abraham G.","family":"Osler","sequence":"first","affiliation":[{"name":"From the Department of Microbiology, The Johns Hopkins School of Hygiene and Public Health, and the Department of Medicine, The Johns Hopkins School of Medicine, Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary M.","family":"Hawrisiak","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology, The Johns Hopkins School of Hygiene and Public Health, and the Department of Medicine, The Johns Hopkins School of Medicine, Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Ovary","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology, The Johns Hopkins School of Hygiene and Public Health, and the Department of Medicine, The Johns Hopkins School of Medicine, Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Siqueira","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology, The Johns Hopkins School of Hygiene and Public Health, and the Department of Medicine, The Johns Hopkins School of Medicine, Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto G.","family":"Bier","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology, The Johns Hopkins School of Hygiene and Public Health, and the Department of Medicine, The Johns Hopkins School of Medicine, Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1957,12,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/106\/6\/811\/1645677\/811.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/106\/6\/811\/1645677\/811.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T18:25:54Z","timestamp":1690223154000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/106\/6\/811\/21360\/STUDIES-ON-THE-MECHANISM-OF-HYPERSENSITIVITY"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1957,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1957,12,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.106.6.811","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1957,12,1]]}}}