{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:10:43Z","timestamp":1758280243473},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1959,6,1]]},"abstract":"<jats:p>The skin of severely scorbutic guinea pigs which were losing weight contained no detectible neutral salt-extractible collagen.<\/jats:p>\n               <jats:p>Conditions of growth (weight gain) which actively induced the formation of neutral salt-extractible collagen in the skin of normal guinea pigs failed to do so in the animal with ascorbic acid deficiency.<\/jats:p>\n               <jats:p>No excess of non-collagenous proline was found in neutral salt extracts of scorbutic skin as compared with normal.<\/jats:p>\n               <jats:p>Fractionation of these extracts failed to reveal the presence of significant amounts of a soluble component containing unusual proportions of glycine and proline relative to hydroxyproline.<\/jats:p>\n               <jats:p>It is concluded that deficiency of ascorbic acid either interferes with the synthesis of new collagen in intact skin or causes its destruction and removal as rapidly as it is produced.<\/jats:p>","DOI":"10.1084\/jem.109.6.557","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"557-569","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["STUDIES ON THE FORMATION OF COLLAGEN"],"prefix":"10.1084","volume":"109","author":[{"given":"Jerome","family":"Gross","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Harvard Medical School and the Medical Services of the Massachusetts General Hospital, Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1959,6,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/109\/6\/557\/1647394\/557.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/109\/6\/557\/1647394\/557.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T18:41:18Z","timestamp":1690224078000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/109\/6\/557\/2645\/STUDIES-ON-THE-FORMATION-OF-COLLAGEN-IV-EFFECT-OF"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1959,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1959,6,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.109.6.557","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1959,6,1]]}}}