{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:11:44Z","timestamp":1756995104231},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1961,8,1]]},"abstract":"<jats:p>Rheumatoid factors in the sera of patients with rheumatoid arthritis appear to be specifically directed against genetically determined \"antigens\" in human \u03b3-globulin. At least eight rheumatoid factors of differing specificity exist; usually several are present in combination in the same serum. The different rheumatoid factors can be readily detected through their pattern of reactivity with anti-Rh antibodies from different individuals. Rheumatoid factors in diseases other than rheumatoid arthritis were found to have a more restricted specificity, contrasted to the broader reactivity of the factors in most rheumatoid arthritis sera. A specificity similar to that for incomplete antibodies was not demonstrated for the reaction of rheumatoid factors with aggregated \u03b3-globulin or with \u03b3-globulin to form the \"22S complex.\"<\/jats:p>\n               <jats:p>In certain instances, using the anti-Rh system, rheumatoid factors were found to react poorly with the patient's own \u03b3-globulin, compared to that of other individuals of different genetic \u03b3-globulin types. These results, as well as additional indirect evidence, indicate that the rheumatoid factors can possess isospecificity. However, a certain degree of autospecificity was also found which was most clearly evident through complex formation with the patients own \u03b3-globulin and in the reaction with aggregates. The relevance of these findings to possible isoantibody as well as autoantibody concepts is discussed.<\/jats:p>","DOI":"10.1084\/jem.114.2.257","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"257-278","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":97,"title":["SPECIFICITY OF THE REACTION BETWEEN RHEUMATOID FACTORS AND GAMMA GLOBULIN"],"prefix":"10.1084","volume":"114","author":[{"given":"Hugh H.","family":"Fudenberg","sequence":"first","affiliation":[{"name":"From The Rockefeller Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry G.","family":"Kunkel","sequence":"additional","affiliation":[{"name":"From The Rockefeller Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1961,8,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/114\/2\/257\/1648797\/257.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/114\/2\/257\/1648797\/257.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T19:09:08Z","timestamp":1690225748000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/114\/2\/257\/2945\/SPECIFICITY-OF-THE-REACTION-BETWEEN-RHEUMATOID"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1961,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1961,8,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.114.2.257","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1961,8,1]]}}}