{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T13:28:57Z","timestamp":1744291737916},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1962,3,1]]},"abstract":"<jats:p>1. Agkistrodon piscivorus venom and E. coli endotoxin were shown to be immunologically distinct, and to differ in certain biologic properties: effects on immune response, body temperature, and circulating leukocyte count, and capacity to prepare for and provoke the local and generalized Shwartzman reaction.<\/jats:p>\n               <jats:p>2. Neither a single prior injection of venom nor the existence of hyperimmunity to lethal doses of venom protected rabbits against the local and generalized Shwartzman reaction.<\/jats:p>\n               <jats:p>3. Serial intravenous injections of sublethal doses of venom produced enhanced susceptibility to venom rather than refractoriness.<\/jats:p>\n               <jats:p>4. Preparation for both the local and generalized Shwartzman reaction with endotoxin appeared to enhance susceptibility of rabbits to challenge with venom.<\/jats:p>\n               <jats:p>5. Tolerance to bacterial pyrogens established by repeated injections of endotoxin is paralleled by increased resistance to snake venom given at least 1 week later, in mice and rabbits.<\/jats:p>\n               <jats:p>6. Zymosan failed to enhance susceptibility of rabbits to venom, but thorotrast increased the number of late deaths from venom.<\/jats:p>\n               <jats:p>7. Exposure of venom to ferrous sulfate interferes with its toxicity.<\/jats:p>","DOI":"10.1084\/jem.115.3.563","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"563-578","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["STUDIES ON THE BIOLOGIC RELATIONSHIP OF ENDOTOXIN AND OTHER TOXIC PROTEINS"],"prefix":"10.1084","volume":"115","author":[{"given":"Richard M.","family":"Condie","sequence":"first","affiliation":[{"name":"From the Pediatric Research Laboratories of the Variety Club Heart Hospital, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward V.","family":"Staab","sequence":"additional","affiliation":[{"name":"From the Pediatric Research Laboratories of the Variety Club Heart Hospital, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Good","sequence":"additional","affiliation":[{"name":"From the Pediatric Research Laboratories of the Variety Club Heart Hospital, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1962,3,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/115\/3\/563\/1649244\/563.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/115\/3\/563\/1649244\/563.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T19:17:06Z","timestamp":1690226226000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/115\/3\/563\/3045\/STUDIES-ON-THE-BIOLOGIC-RELATIONSHIP-OF-ENDOTOXIN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1962,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1962,3,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.115.3.563","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1962,3,1]]}}}