{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T19:40:05Z","timestamp":1690227605523},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1962,3,1]]},"abstract":"<jats:p>1. Injections of sublethal quantities of Agkistrodon piscivorus venom into endotoxin-treated rabbits produces a consistent early death.<\/jats:p>\n               <jats:p>2. The endotoxin-induced hypersusceptibility state (EIHS) to venom is produced by intravenous, intradermal, and intraperitoneal administration of endotoxin. The latency and duration of the EIHS vary with the route of administration.<\/jats:p>\n               <jats:p>3. EIHS is induced by as little as 1 gamma of endotoxin administered intravenously. Although the degree of susceptibility was no greater with a 100 gamma dose than with 1 gamma, 1 mg of endotoxin made the rabbits susceptible to smaller venom doses.<\/jats:p>\n               <jats:p>4. EIHS was demonstrated with intravenous, intradermal and intraperitoneal injection of Agkistrodon piscivorus venom. Endotoxin-pretreated animals were not as susceptible to venom given intramuscularly.<\/jats:p>\n               <jats:p>5. Normal rabbits are very resistant to venom given intradermally and intraperitoneally.<\/jats:p>\n               <jats:p>6. Enhanced susceptibility to intravenous endotoxin was demonstrated in animals pretreated with sublethal doses of moccasin venom. It differed from EIHS in its short duration and its outcome: a late, slowly progressive death.<\/jats:p>\n               <jats:p>7. EIHS was demonstrated with other venoms: Crotalus adamanteus and Vipera russellii, and in a modified form (resulting in late death) with Notechis scutatus. Endotoxin pretreatment had no effect on susceptibility to Naja flava, Bungarus candidus, or Crotalus durissus terrificus venoms.<\/jats:p>\n               <jats:p>8. Major hypotheses regarding the nature of endotoxin-induced alterations in non-specific resistance were considered in relation to EIHS to venom.<\/jats:p>","DOI":"10.1084\/jem.115.3.579","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"579-596","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["STUDIES ON THE BIOLOGIC RELATIONSHIP OF ENDOTOXIN AND OTHER TOXIC PROTEINS"],"prefix":"10.1084","volume":"115","author":[{"given":"Edward V.","family":"Staab","sequence":"first","affiliation":[{"name":"From the Pediatric Research Laboratories of the Variety Club Heart Hospital, University of Minnesota, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Condie","sequence":"additional","affiliation":[{"name":"From the Pediatric Research Laboratories of the Variety Club Heart Hospital, University of Minnesota, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Good","sequence":"additional","affiliation":[{"name":"From the Pediatric Research Laboratories of the Variety Club Heart Hospital, University of Minnesota, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1962,3,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/115\/3\/579\/1649213\/579.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/115\/3\/579\/1649213\/579.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T19:15:58Z","timestamp":1690226158000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/115\/3\/579\/3043\/STUDIES-ON-THE-BIOLOGIC-RELATIONSHIP-OF-ENDOTOXIN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1962,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1962,3,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.115.3.579","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1962,3,1]]}}}