{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:46:47Z","timestamp":1758818807245},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1963,4,1]]},"abstract":"<jats:p>1. The removal of the \u00df2A-globulins from three sera from treated ragweed-sensitive individuals by immune absorption was associated with the loss of all detectable skin-sensitizing antibody activity as demonstrated by Prausnitz-Ku\u0308stner testing.<\/jats:p>\n               <jats:p>2. Gel filtration studies, with sephadex G-200, indicated that the fractions containing only macroglobulins were devoid of all detectable skin-sensitizing antibody activity.<\/jats:p>\n               <jats:p>3. The immune absorption of the \u03b3-globulins from a serum fraction containing \u00df2A-globulins, \u03b3-globulins, and a trace of \u00df2M-globulins had no detectable influence on the skin-sensitizing antibody activity.<\/jats:p>\n               <jats:p>4. The removal of a portion of the albumin from the allergic sera by immune absorption, with retention of the skin-sensitizing activity, indicated that the loss of skin-sensitizing antibody was not due to non-specific absorption on an antigen-antibody precipitate.<\/jats:p>\n               <jats:p>5. No inhibition of the Prausnitz-Ku\u0308stner reaction was observed when sheep serum, normal human serum, or normal human \u03b3-globulins were tested in concentrations described.<\/jats:p>\n               <jats:p>6. We conclude that the skin-sensitizing antibody activities in the three sera from treated ragweed-sensitive individuals studied were associated with the \u00df2A-globulins.<\/jats:p>","DOI":"10.1084\/jem.117.4.603","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"603-620","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":109,"title":["THE ASSOCIATION OF SKIN-SENSITIZING ANTIBODY WITH THE \u00df2A-GLOBULINS IN SERA FROM RAGWEED-SENSITIVE PATIENTS"],"prefix":"10.1084","volume":"117","author":[{"given":"Philip","family":"Fireman","sequence":"first","affiliation":[{"name":"From the Laboratory of Clinical Investigations and the Laboratory of Immunology, the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilton E.","family":"Vannier","sequence":"additional","affiliation":[{"name":"From the Laboratory of Clinical Investigations and the Laboratory of Immunology, the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard C.","family":"Goodman","sequence":"additional","affiliation":[{"name":"From the Laboratory of Clinical Investigations and the Laboratory of Immunology, the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1963,4,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/117\/4\/603\/1649764\/603.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/117\/4\/603\/1649764\/603.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T19:30:08Z","timestamp":1690227008000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/117\/4\/603\/3501\/THE-ASSOCIATION-OF-SKIN-SENSITIZING-ANTIBODY-WITH"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1963,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1963,4,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.117.4.603","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1963,4,1]]}}}