{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T13:48:19Z","timestamp":1698932899537},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1963,12,1]]},"abstract":"<jats:p>Guinea pigs fed picryl chloride to induce specific immunologic unresponsiveness cleared small amounts of venously infused antipicryl antibody at a rate equal to that of normal guinea pigs.<\/jats:p>\n               <jats:p>Catabolism of passively administered picryl-specific antibody did not alter the unresponsive state of picryl chloride-fed guinea pigs or the responsive state of normal guinea pigs.<\/jats:p>\n               <jats:p>Lymphoid cells of picryl chloride immunized guinea pigs produced equal amounts of picryl-specific antibody in picryl chloride-fed and normal animals.<\/jats:p>\n               <jats:p>Allergen-fed guinea pigs remained unresponsive to attempted sensitization with the allergen in excess of 10 months after the final feeding, though some became feebly sensitive between 9 and 11 months. Second attempts to make unresponsive animals hypersensitive were unsuccessful.<\/jats:p>\n               <jats:p>White blood cells of guinea pigs unresponsive to picryl chloride were unable to transfer delayed-type hypersensitivity for picryl chloride to normal recipients yet readily transferred tuberculin hypersensitivity.<\/jats:p>","DOI":"10.1084\/jem.118.6.1021","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"1021-1035","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["IMMUNOLOGICAL UNRESPONSIVENESS TO SENSITIZATION WITH SIMPLE CHEMICAL COMPOUNDS"],"prefix":"10.1084","volume":"118","author":[{"given":"Jack R.","family":"Battisto","sequence":"first","affiliation":[{"name":"From the Albert Einstein College of Medicine of Yeshiva University and The Rockefeller Institute, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merrill W.","family":"Chase","sequence":"additional","affiliation":[{"name":"From the Albert Einstein College of Medicine of Yeshiva University and The Rockefeller Institute, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1963,12,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/118\/6\/1021\/1650136\/1021.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/118\/6\/1021\/1650136\/1021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T19:35:56Z","timestamp":1690227356000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/118\/6\/1021\/3669\/IMMUNOLOGICAL-UNRESPONSIVENESS-TO-SENSITIZATION"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1963,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1963,12,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.118.6.1021","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1963,12,1]]}}}